Results 51 to 60 of about 26,416 (261)

Obesity dependent metabolic signatures associated with nonalcoholic fatty liver disease progression [PDF]

, 2012
Our understanding of the mechanisms by which nonalcoholic fatty liver disease (NAFLD) progresses from simple steatosis to steatohepatitis (NASH) is still very limited.
Alonso, C, Barr, J, Caballería, J, Domínguez-Díez, A, Martínez Arranz, Ibon, Moto, J.M., Muntané Relat, Jordi, Romero Gómez, Manuel   +7 more
core  

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source

Phosphatidylcholine synthesis through cholinephosphate cytidylyltransferase is dispensable in Leishmania major [PDF]

, 2019
© 2019, The Author(s). cc-byPhosphatidylcholine (PC) is a major cell membrane constituent and precursor of important second messengers. In Leishmania parasites, PC synthesis can occur via the choline branch of the Kennedy pathway, the N-methylation of ...
Hsu, Fong-Fu, Moitra, Samrat, Pawlowic, Mattie C., Zhang, Kai   +3 more
core   +3 more sources

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

Advanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu, Abudureyimujiang Aili, Zheng Kuang, Liting Cao, Zemin Li, Ying Shang, Yingying Ge, Tingting Hu, Yongchang Sun, Wuli Zhao, Rong Jin, Chun Chang   +11 more
wiley   +1 more source

Lipidomic UPLC-MS/MS Profiles of Normal-Appearing White Matter Differentiate Primary and Secondary Progressive Multiple Sclerosis

Metabolites, 2020
Multiple sclerosis (MS) is a neurodegenerative inflammatory disease where an autoimmune response to components of the central nervous system leads to a loss of myelin and subsequent neurological deterioration.
Petros Pousinis, Ines R. Ramos, M. Nicola Woodroofe, Laura M. Cole   +3 more
doaj   +1 more source

Endothelial ether lipids link the vasculature to blood pressure, behavior, and neurodegeneration

Journal of Lipid Research, 2021
Vascular disease contributes to neurodegeneration, which is associated with decreased blood pressure in older humans. Plasmalogens, ether phospholipids produced by peroxisomes, are decreased in Alzheimer's disease, Parkinson's disease, and other ...
Larry D. Spears, Sangeeta Adak, Guifang Dong, Xiaochao Wei, George Spyropoulos, Qiang Zhang, Li Yin, Chu Feng, Donghua Hu, Irfan J. Lodhi, Fong-Fu Hsu, Rithwick Rajagopal, Kevin K. Noguchi, Carmen M. Halabi, Lindsey Brier, Annie R. Bice, Brian V. Lananna, Erik S. Musiek, Oshri Avraham, Valeria Cavalli, Jerrah K. Holth, David M. Holtzman, David F. Wozniak, Joseph P. Culver, Clay F. Semenkovich   +24 more
doaj   +1 more source

The SwissLipids knowledgebase for lipid biology. [PDF]

, 2015
MOTIVATION: Lipids are a large and diverse group of biological molecules with roles in membrane formation, energy storage and signaling. Cellular lipidomes may contain tens of thousands of structures, a staggering degree of complexity whose significance ...
Aimo, L., Bougueleret, L., Bridge, A., David, F.P., Gleizes, A., Götz, L., Hyka-Nouspikel, N., Kuznetsov, D., Liechti, R., Niknejad, A., Riezman, H., van der Goot, F.G., Xenarios, I.   +12 more
core   +3 more sources

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

Variations in pleural microbiota and metabolic phenotype associated with malignant pleural effusion in human lung adenocarcinoma

Thoracic Cancer, 2023
Background Lung cancer is the most common cancer‐related death worldwide. In 2022, the number of daily deaths of lung cancer was estimated to reach around 350 in the United States.
DanHui Huang, JinZhong Zhuo, CuiPing Ye, XiaoFang Su, YueHua Chen, Cui Li, LiSan Lin, LaiYu Liu, Haijin Zhao, Tingyue Luo, QianNan Ren, JianHua Wu, Shaoxi Cai, Hangming Dong   +13 more
doaj   +1 more source

Changes in lipid distribution in E. coli strains in response to norfloxacin [PDF]

, 2015
Bacterial resistance to antibiotics has become an increasing threat, requiring not only the development of new targets in drug discovery, but more importantly, a better understanding of cellular response.
Fernandez-Lima, Francisco, Nau, Frederic, Schenk, Emily R., Thompson, Christopher J., Tse-Dinh, Yuk-Ching   +4 more
core   +2 more sources