Results 191 to 200 of about 614,935 (241)

Gut <i>Proteobacteria</i> glycine metabolism regulates neuroplasticity, motivation, and reinstatement of cocaine self-administration in mice. [PDF]

Gut Microbes
Delgado Ocaña S, Herrera G, Guzmán D, Self DW, Cuesta S.   +4 more
europepmc   +1 more source

THSD7A Exacerbates Atherosclerosis via Activation of Signaling Axis αvβ3/CEBPD/IL1A

Advanced Science, EarlyView.
THSD7A exerts pro‐inflammatory effects and exacerbates atherosclerosis. Mechanistically, THSD7A regulates endothelial cell inflammation and atherosclerosis by activating the αvβ3/CEBPD/IL1A signaling axis. THSD7A is not only a genetic marker but also a potential therapeutic target for coronary artery disease (CAD).
Jiankun Liu, Hongfei Liu, Yiqi Wan, Andong Wu, Jiayu Qiu, Xueting Gong, Ya Zhao, Yuanyuan Li, Bingbing Zhou, Yangyi Zheng, Fang Wu, Yuanzheng Zhu, Weixin Lv, Xueer Li, Qiang Yuan, Xiao‐Li Tian   +15 more
wiley   +1 more source

Optimal Combination of Glycine, Asparagine, and Phenylalanine Promotes α-Casein Synthesis and Secretion in MAC-T Cells Through Activation of the PI3K-AKT-mTOR Pathway. [PDF]

Animals (Basel)
Zhang X, Ding Y, Yang M, Luo R, Yang Y, Zhang H, Ren W, Yang L, Wei Y, Zhao Y, Guo T, Shao W.   +11 more
europepmc   +1 more source

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

Advanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai, Xin Mei Zhang, Jing Cheng Zhang, Xu Ting Deng, Qiao Liu, Mustafa Hussein Ali, Fang Zhou Yin, Wu Yin   +7 more
wiley   +1 more source

A Genetically Encoded Electrophilic Lysine Derivative Enables Sortase-Mediated Assembly of SUMO Activity-Based Probes. [PDF]

J Am Chem Soc
Wanka V, Kvasha D, Cigler M, Heymes-Krauskopf K, Ruckgaber P, Heider A, Fottner M, Groll M, Lang K.   +8 more
europepmc   +1 more source

Ninjurin-1 mediates hepatic ischemia-reperfusion injury. [PDF]

Sci Adv
Mossemann J, Martins BX, Zhao Y, Aguilar F, Taskina D, Hur CJ, Nakib D, Volchuk A, Ye G, Ali DM, Mirzaesmaeili A, Siddiqui I, Goodarzi G, Bilan PJ, Stowe IB, Kayagaki N, MacParland S, Freeman SA, Goldenberg NM, Steinberg BE, Sayed BA.   +20 more
europepmc   +1 more source

Backbone Nitrogen Substitution Probes the Role of Glycine Residues at GxxxG Interfaces in Transmembrane Helices. [PDF]

Biochemistry
Thomas D, Gu F, Newberry RW.
europepmc   +1 more source

Nonnative Thiol and Aniline Methylation, Including Enantioselective Dithiol Desymmetrization, by Multicomponent Cobamide-Dependent Methyltransferases Using Unactivated Methyl Donors. [PDF]

Angew Chem Int Ed Engl
Kumar A, Adam OI, Gupta P, Lewis JC.
europepmc   +1 more source

Recent progress in the structure-activity relationship of antibacterial peptoids. [PDF]

RSC Adv
Bahatheg G, Ibisanmi TA, Black DS, Willcox MDP, Kumar N.   +4 more
europepmc   +1 more source

Synaptic vs. Non-Synaptic Glycine Receptors: Physiological Role and Implications in Alzheimer's Disease Pathology. [PDF]

Int J Mol Sci
Kiss E, Kirsch J, Kins S, Kuhse J.
europepmc   +1 more source