Impaired Verbal Memory Recall in Patients With Axonal Degeneration and Serum Glycine-Receptor Autoantibodies—Case Series [PDF]
Frontiers in Psychiatry, 2022 BackgroundGlycine receptor antibody-associated neuropsychiatric disease is currently known to be dominated by the phenotypes stiff-person syndrome and progressive encephalomyelitis entailing rigidity and myoclonus. In our case series we aim to depict the
Niels Hansen +6 more
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Molecular determinants of cesium- and glycine-dependent glycine receptor activation [PDF]
Scientific ReportsThe neurotransmitter receptor for glycine (GlyR) is a ligand-gated chloride-permeable ion channel in the central nervous system, and dysregulation of this channel is associated with diverse neurological disorders. Cesium (Cs+) is an agonist of GlyRs, and
Magnus Harnau +3 more
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Glycine receptor autoantibody binding to the extracellular domain is independent from receptor glycosylation [PDF]
Frontiers in Molecular Neuroscience, 2023 Glycine receptor (GlyR) autoantibodies are associated with stiff-person syndrome and the life-threatening progressive encephalomyelitis with rigidity and myoclonus in children and adults.
Vera Rauschenberger +13 more
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The emerging role of glycine receptor α2 subunit defects in neurodevelopmental disorders [PDF]
Frontiers in Molecular NeuroscienceRare neurodevelopmental disorders (NDDs) are one of the most significant unmet challenges in healthcare due to their lifelong nature, high management costs, and recurrence within families.
Sean D. Fraser +3 more
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Clinical, genetic, and functional characterization of the glycine receptor β-subunit A455P variant in a family affected by hyperekplexia syndrome. [PDF]
J Biol Chem, 2022 Aboheimed GI +13 more
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Progressive encephalomyelitis with rigidity and myoclonus initially diagnosed as an anxiety disorder associated with anti-glycine receptor antibodies: A case report. [PDF]
J Int Med ResJiang Y, Wang C, Liu C.
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Differentiated human midbrain-derived neural progenitor cells express excitatory strychnine-sensitive glycine receptors containing α2β subunits. [PDF]
PLoS ONE, 2012 BACKGROUND: Human fetal midbrain-derived neural progenitor cells (NPCs) may deliver a tissue source for drug screening and regenerative cell therapy to treat Parkinson's disease.
Florian Wegner +7 more
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Frontiers in Psychiatry, 2020 Treatment-resistant schizophrenia (TRS) or suboptimal response to antipsychotics affects almost 30% of schizophrenia (SCZ) patients, and it is a relevant clinical issue with significant impact on the functional outcome and on the global burden of disease.
Andrea de Bartolomeis +6 more
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Frontiers in Molecular Neuroscience, 2016 NMDA receptors are Ca2+-permeable ion channels. The activation of NMDA receptors requires agonist glutamate and co-agonist glycine. Recent evidence indicates that NMDA receptor also has metabotropic function.
Li-Jun Li +15 more
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Conformational variability of the glycine receptor M2 domain in response to activation by different agonists [PDF]
, 2007 Models describing the structural changes mediating cys-loop receptor activation generally give little attention to the possibility that different agonists may promote activation via distinct M2 pore-lining domain structural rearrangements.
Akabas +30 more
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