Results 171 to 180 of about 398,460 (354)

Illumination of a progressive allosteric mechanism mediating the glycine receptor activation. [PDF]

Nat Commun, 2023
Shi S, Lefebvre SN, Peverini L, Cerdan AH, Milán Rodríguez P, Gielen M, Changeux JP, Cecchini M, Corringer PJ.   +8 more
europepmc   +1 more source

Nanoscale Mapping of the Subcellular Glycosylation Landscape

Advanced Science, EarlyView.
Using multiplexed super‐resolution imaging with fluorophore‐labeled lectins, this study reports intracellular glycosylation at the nanoscale across organelles and synaptic specializations. Extending glycan analysis beyond the cell surface, Glyco‐STORM reveals distinct glycosylation nanodomains in the ER, Golgi, lysosomes, and synaptic sites.
Helene Gregoria Schroeter, Steffen Sass, Mike Heilemann, Thomas Kuner, Maja Klevanski   +4 more
wiley   +1 more source

Comprehensive behavioral analyses of mice with a glycine receptor alpha 4 deficiency. [PDF]

Mol Brain, 2023
Darwish M, Hattori S, Nishizono H, Miyakawa T, Yachie N, Takao K.   +5 more
europepmc   +1 more source

Functional Consequences of Reduction in NMDA Receptor Glycine Affinity in Mice Carrying Targeted Point Mutations in the Glycine Binding Site [PDF]

, 2000
James N.C. Kew, Anja Köester, Jean‐Luc Moreau, François Jenck, Abdel‐Mouttalib Ouagazzal, Vincent Mutel, J. G. Richards, Gerhard Trube, Guenther Fischer, Alexandra Montkowski, W. Hundt, Rainer K. Reinscheid, Meike Pauly-Evers, John A. Kemp, Horst Bluethmann   +14 more
openalex   +1 more source

Vitamin D Regulates Olfactory Function via Dual Transcriptional and mTOR‐Dependent Translational Control of Synaptic Proteins

Advanced Science, EarlyView.
Vitamin D (VitD) modulates olfactory function by remodeling dendrodendritic synapses in tufted cells through vitamin D receptor‐dependent transcriptional and translational mechanisms. VitD regulates synaptic protein translation partially via mTOR signaling.
Pengcheng Ren, Renhe Cao, Xiaoshan Ye, Wenbin Pang, Qingshang Bi, Meihui Huang, Qionglin Zhou, Dan Ye, Wei Xiang, Le Xiao   +9 more
wiley   +1 more source

Anti-Glycine Receptor Antibody-Associated Lateral Tractopathy. [PDF]

Neurohospitalist, 2023
Vázquez-Vélez GE, Perez EJ.
europepmc   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Progressive encephalomyelitis with rigidity and myoclonus (PERM) associated with anti-glycine receptor antibodies and urothelial carcinoma: a case report. [PDF]

J Med Case Rep, 2023
Ali AH, Benterud A, Holmøy T, Myro AZ.
europepmc   +1 more source

N-Glycine-sulfonamides as potent dual orexin 1/orexin 2 receptor antagonists

, 2008
Hamed Aissaoui, Ralf Koberstein, Cornelia Zumbrunn, John Gatfield, Catherine Brisbare‐Roch, François Jenck, Alexander Treiber, Christoph Boss   +7 more
openalex   +1 more source

USP9X as a Candidate Mediator of Prenatal Aspirin‐Induced Ovarian Reserve Reduction in Offspring Mice

Advanced Science, EarlyView.
This study suggests that prenatal aspirin exposure is associated with reduced ovarian reserve in offspring, associated with HDAC1‐linked epigenetic downregulation of Usp9x as a candidate mechanism. These preclinical findings provide new insights into fetal‐origin ovarian disorders and contribute to the evidence base concerning aspirin's gestational ...
Yating Li, Caiyun Ge, Wai Yen Yim, Hui Feng, Tiancheng Wu, Lu Chen, Qiaohua Xiong, Shumin Pan, Mei Wang, Huijun Chen, Yuanzhen Zhang, Hui Wang   +11 more
wiley   +1 more source