Results 41 to 50 of about 2,731,322 (279)

Taurine: A Maternally Derived Nutrient Linking Mother and Offspring

Metabolites, 2022
Mammals can obtain taurine from food and synthesize it from sulfur-containing amino acids. Mammalian fetuses and infants have little ability to synthesize taurine. Therefore, they are dependent on taurine given from mothers either via the placenta or via
Shiro Tochitani
doaj   +1 more source

High-throughput screening in larval zebrafish identifies novel potent sedative-hypnotics [PDF]

, 2018
BACKGROUND: Many general anesthetics were discovered empirically, but primary screens to find new sedative-hypnotics in drug libraries have not used animals, limiting the types of drugs discovered.
Brown, Lauren E., Dai, Jennifer B., Daigle, Renee, Forman, Stuart A., Halpin, Elizabeth S., Jounaidi, Youssef, Marte-Oquendo, Francisco, Porco, John A., Schaus, Scott E., Trilles, Richard, Xu, Wenqing, Yang, Xiaoxuan, Yu, Buwei   +12 more
core   +1 more source

4-Chloropropofol enhances chloride currents in human hyperekplexic and artificial mutated glycine receptors

BMC Neurology, 2012
Background The mammalian neurological disorder hereditary hyperekplexia can be attributed to various mutations of strychnine sensitive glycine receptors.
de la Roche Jeanne, Leuwer Martin, Krampfl Klaus, Haeseler Gertrud, Dengler Reinhard, Buchholz Vanessa, Ahrens Jörg   +6 more
doaj   +1 more source

New immunolatex spheres: visual markers of antigens on lymphocytes for scanning electron microscopy [PDF]

, 1975
New immunochemical reagents consisting of antibodies bound to small latex spheres were used as visual markers for the detection and localization of cell surface antigens by scanning electron microscopy.
Dreyer, William J., Molday, Robert S., Rembaum, Alan, Yen, S. P. S.   +3 more
core   +2 more sources

A non-ionotropic activity of NMDA receptors contributes to glycine-induced neuroprotection in cerebral ischemia-reperfusion injury

Scientific Reports, 2017
NMDA receptor (NMDAR) is known for its ionotropic function. But recent evidence suggests that NMDAR also has a non-ionotropic property. To determine the role of non-ionotropic activity of NMDARs in clinical relevant conditions, we tested the effect of ...
Juan Chen, Rong Hu, Huabao Liao, Ya Zhang, Ru Lei, Zhifeng Zhang, Yang Zhuang, Y. Wan, Ping Jin, H. Feng, Q. Wan   +10 more
semanticscholar   +1 more source

New Therapeutic Strategy for Amino Acid Medicine: Glycine Improves the Quality of Sleep

Journal of Pharmacological Sciences, 2012
Glycine is a non-essential amino acid that has indispensable roles in both excitatory and inhibitory neurotransmission via N-methyl-D-aspartate type glutamate receptors and glycine receptors, respectively.
Makoto Bannai, Nobuhiro Kawai
doaj   +1 more source

CNS4 causes subtype‐specific changes in agonist efficacy and reversal potential of permeant cations in NMDA receptors

Pharmacology Research & Perspectives, 2023
The NMDA subtype of glutamate receptor serves as an attractive drug target for the treatment of disorders evolving from hyper‐ or hypoglutamatergic conditions.
Seth C. Boehringer, Tullia V. Johnston, Lina Cortez Kwapisz, Pamela J. VandeVord, Blaise M. Costa   +4 more
doaj   +1 more source

Conformational variability of the glycine receptor M2 domain in response to activation by different agonists [PDF]

, 2007
Models describing the structural changes mediating cys-loop receptor activation generally give little attention to the possibility that different agonists may promote activation via distinct M2 pore-lining domain structural rearrangements.
Akabas, Chang, Cymes, Cymes, Dahan, England, Gandhi, Grosman, Han, Hawthorne, Hawthorne, Hemmings, Kondratskaya, Kondratskaya, Law, Lee, Lewis, Lobo, Lynch, Lynch, Lynch, Miyazawa, Muroi, O'Shea, Paas, Rajendra, Shan, Unwin, Unwin, Webb, Wilson   +30 more
core   +3 more sources

Glycine Release Is Upregulated by Metabotropic Glutamate Receptor 1 in Mouse Hippocampus

Biomedicines
Background/Objectives: The neurotransmitter glycine is involved in several physiological and pathological conditions in the Central Nervous System. Different biological structures, including glycine receptors and transporters, are under study as targets ...
Luca Raiteri, Maria Cerminara, Aldamaria Puliti, Anna Pittaluga   +3 more
doaj   +1 more source

Subregion-specific modulation of excitatory input and dopaminergic output in the striatum by tonically activated glycine and GABAA receptors

Frontiers in Systems Neuroscience, 2011
The flow of cortical information through the basal ganglia is a complex spatiotemporal pattern of increased and decreased firing. The striatum is the biggest input nucleus to the basal ganglia and the aim of this study was to assess the role of ...
Louise eAdermark, Rhona B Clarke, Mia eEricson, Bo eSöderpalm   +3 more
doaj   +1 more source