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Glycitein induces cellular differentiation in nontumorigenic prostate epithelial cells [PDF]
The FASEB Journal, 2007 Epidemiological and experimental evidence suggests that increased consumption of soy is associated with a reduced risk for prostate cancer. Soy isoflavones are thought to be responsible, in part, for this anticancer activity. Soy isoflavones have been shown to induce cellular differentiation in a number of tissues.
Elizabeth A. Clubbs, Joshua A. Bomser
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The synthesis of [2,3,4-13C3]glycitein
Tetrahedron, 2004Glycitein is one of the soy isoflavones which have attracted considerable interest in recent years due to their possible beneficial effects on human health. However, glycitein has been much less studied than other members of this family due to the lack of good methods for its synthesis. Herein we report a short high yielding synthesis of a multiply 13C-
Qingzhi Zhang, Nigel P. Botting
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Genistein and Daidzein/Glycitein Content in Tofu
Journal of Food Composition and Analysis, 2001The consumption of soyfoods is of great interest because of their proposed anticancer and antiatherogenic activity. It has been suggested that the soy isoflavones genistein and daidzein are responsible for these activities. The objective of this study was to determine the variation of the isoflavone content of commercially available packaged tofu by ...
Ed Hui +5 more
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Isoflavone Glycitein Diminished Plasma Cholesterol in Female Golden Syrian Hamsters
Journal of Agricultural and Food Chemistry, 2007The soybean isoflavones, daidzein, genistein, and glycitein, were hypothesized to act as cholesterol-lowering components, separate from soy protein. Pure synthetic daidzein, genistein, or glycitein (0.9 mmol/kg diet) or a casein-based control diet was fed to groups of 10 female Golden Syrian hamsters for 4 weeks.
Lee, Sun-Ok +4 more
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CHAPTER 28. Glycitein in Health
2012Glycitein is the third most abundant isoflavone found in soy. While there is a link between isoflavone consumption and improved health, there is gap in understanding how glycitein itself and glycitein-rich foods influence human health. While the majority of research in the area of soy and health has focused on genistein and daidzein, this Chapter will ...
Brian R. Stephens, Joshua A. Bomser
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Basal Cell Induced Differentiation of Noncancerous Prostate Epithelial Cells (RWPE-1) by Glycitein
Nutrition and Cancer, 2009Increased consumption of soy and soy isoflavones is associated with a reduced risk for prostate cancer (PCa). PCa progression is characterized, in part, by a loss of luminal/basal epithelial differentiation; however, the effects of soy isoflavones on cellular differentiation in the prostate are unknown. The present study examined the effects of the soy
Elizabeth A, Clubbs, Joshua A, Bomser
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Bioavailability of glycitein relatively to other soy isoflavones in healthy young Caucasian men
Food Chemistry, 2012 Glycitein is a Selective Estradiol Receptor Modulator (SERM) from soy. The study reports plasma bioavailability and urine excretion of glycitein compared to other soy isoflavones after a unique intake of food supplement based on soy germ containing 55.24mg isoflavones.
Svitlana Shinkaruk +9 more
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In vitro and in vivo metabolism of the soy isoflavone glycitein
Molecular Nutrition & Food Research, 2007AbstractGlycitein (GLY) is a major isoflavone of soy germ which is used as a functional ingredient to enrich foods with isoflavones as well as a component of soy supplements. Since data on the metabolism of GLY are incomplete, the in vitro phase I metabolism of GLY using rat liver microsomes, human liver microsomes (HLM), as well as human fecal flora ...
Corinna E, Rüfer +4 more
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Effect of thermal processing on genistein, daidzein and glycitein content in soymilk
Journal of the Science of Food and Agriculture, 2006AbstractSoymilk was subjected to various heat treatments at 95, 121 and 140 °C for various lengths of time. The contents of the aglycones of isoflavone (daidzein, glycitein and genistein) of the soymilk were determined using C18 reversed‐phase high‐performance liquid chromatography. Genistein showed greater stability to heat treatment than daidzein and
Huihua Huang +2 more
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Glycitein inhibits glioma cell invasion through down-regulation of MMP-3 and MMP-9 gene expression
Chemico-Biological Interactions, 2010Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that play a pivotal role in invasion and angiogenesis of malignant glioma cells. Therefore, the inhibition of MMPs has been suggested to be a promising therapeutic strategy for brain tumors. In the present study, we found that glycitein, a bacterial metabolite of the isoflavone glycitin,
Eun-Jung, Lee +5 more
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