Results 111 to 120 of about 43,679 (304)

Therapeutic Reprogramming of Glioblastoma Phenotypic States Using Multifunctional Heparin Nanoparticles

Advanced Science, EarlyView.
This study presents heparin‐derived nanoparticles (HP‐NPs) as a novel precision medicine platform that combines therapeutic and delivery functions. HP‐NPs target drug‐resistant glioblastoma stem cells, reprogramming them into a drug‐sensitive phenotype and significantly reducing tumor progression.
Vadim Le Joncour, Austin D. Evans, Camilla Karoliina Bergström, Vignesh Kumar Rangasami, Sumanta Samanta, Nithiyanandan Krishnan, Yuji Teramura, Bo Nilsson, Patricia Hedenqvist, Elin Manell, Jons Hilborn, Marianne‐Jensen Waern, Oommen P. Varghese, Pirjo Laakkonen, Oommen P. Oommen   +14 more
wiley   +1 more source

Lectin Staining of Microvascular Glycocalyx in Microfluidic Cancer Cell Extravasation Assays

Life, 2021
The endothelial glycocalyx forms the inner-most lining of human microvasculature. It ensures the physiological function of blood vessels and plays a crucial role in the occurrence and progression of microvascular diseases.
Sebastian Beyer, Anna Blocki, Matthew Chung Yin Cheung, Zoe Ho Ying Wan, Babak Mehrjou, Roger Dale Kamm   +5 more
doaj   +1 more source

Multi-scale interaction of flow and the artery wall [PDF]

, 2009
We discuss, from the perspective of basic science, the physical and biological processes which underlie atherosclerotic (plaque) initiation at the vascular endothelium, identifying their widely separated spatial and temporal scales which participate.
2nd Micro and Nano Flows Conference (MNF2009), Atherton, MA, Care, CM, Collins, MW, Evans, D, Evans, PC, Halliday, I, Hose, DR, Khir, A, Krams, R, Lawford, PV, Lishchuk, SV, Ridger, V, Ventikos, Y, Walker, DC, Watton, PN   +15 more
core  

Endothelial glycocalyx shields the interaction of SARS-CoV-2 spike protein with ACE2 receptors

Scientific Reports, 2021
Endothelial cells (ECs) play a crucial role in the development and propagation of the severe COVID-19 stage as well as multiorgan dysfunction. It remains, however, controversial whether COVID-19-induced endothelial injury is caused directly by the ...
M. Targosz-Korecka, Agata Kubisiak, D. Kloska, A. Kopacz, A. Grochot-Przęczek, M. Szymoński   +5 more
semanticscholar   +1 more source

PIEZO Force Sensing in Vascular Biology: An Explosion of New Knowledge, Concepts and Opportunity

Advanced Science, EarlyView.
Knowledge of the remarkable mechanical force sensing and electrically transducing PIEZO1 and PIEZO2 channels is discussed across vascular biology and its cell types from the embryonic to adult stages in health, disease and old age. How the channels work, relate to other factors and signal for tissue responses to mechanical forces is debated.
David J Beech
wiley   +1 more source

Protectin conjugates in tissue regeneration 1 restores lipopolysaccharide-induced pulmonary endothelial glycocalyx loss via ALX/SIRT1/NF-kappa B axis

Respiratory Research, 2021
Background Endothelial glycocalyx loss is integral to increased pulmonary vascular permeability in sepsis-related acute lung injury. Protectin conjugates in tissue regeneration 1 (PCTR1) is a novel macrophage-derived lipid mediator exhibiting potential ...
Xin-Yang Wang, Xin-Yu Li, Cheng-Hua Wu, Yu Hao, Pan-Han Fu, Hong-Xia Mei, Fang Chen, Yu-Qiang Gong, Sheng-Wei Jin, Hui Li   +9 more
doaj   +1 more source

Injury to the Endothelial Glycocalyx in Critically Ill Patients with COVID-19

American Journal of Respiratory and Critical Care Medicine, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the so-called coronavirus disease (COVID-19), which is characterized by a broad spectrum of clinical presentations ranging from asymptomatic patients to critically ill individuals with a
K. Stahl, Phillip Alexander Gronski, Y. Kiyan, B. Seeliger, Anna Bertram, T. Pape, T. Welte, M. Hoeper, H. Haller, S. David   +9 more
semanticscholar   +1 more source

Interaction of Nucleic Acids with the Glycocalyx [PDF]

Journal of the American Chemical Society, 2012
Mammalian cells resist the uptake of nucleic acids. The lipid bilayer of the plasma membrane presents one barrier. Here, we report on a second physicochemical barrier for uptake. To create a sensitive probe for nucleic acid-cell interactions, we synthesized fluorescent conjugates in which lipids are linked to DNA oligonucleotides.
Michael J. Palte, Ronald T. Raines
openaire   +3 more sources

Flow induces barrier and glycocalyx-related genes and negative surface charge in a lab-on-a-chip human blood-brain barrier model

Journal of Cerebral Blood Flow and Metabolism, 2021
Microfluidic lab-on-a-chip (LOC) devices allow the study of blood-brain barrier (BBB) properties in dynamic conditions. We studied a BBB model, consisting of human endothelial cells derived from hematopoietic stem cells in co-culture with brain pericytes,
A. R. Santa-Maria, F. Walter, R. Figueiredo, András Kincses, Judit P. Vigh, M. Heymans, M. Culot, P. Winter, F. Gosselet, A. Dér, M. Deli   +10 more
semanticscholar   +1 more source

Syndecan-1, an indicator of endothelial glycocalyx degradation, predicts outcome of patients admitted to an ICU with COVID-19 [PDF]

, 2021
Dong Zhang, Liubing Li, Yu Chen, Jie Ma, Yanli Yang, Surita Aodeng, Qiuju Cui, Kedi Wen, Meng Xiao, Jing Xie, Yingchun Xu, Yongzhe Li   +11 more
openalex   +1 more source