Results 221 to 230 of about 260,438 (309)

Manipulation of Wnt/β‐Catenin Signaling by Synthetic Frizzled Agonist and LRP Antagonist in Organoid Cultures and In Vivo

open access: yesSmall Methods, EarlyView.
Harnessing synthetic key receptor modulators, this study presents a breakthrough in Wnt/β‐catenin regulation. The FZD agonist RRP‐pbFn bypasses LRP5/6 to drive organoid expansion and tissue regeneration, while the LRP antagonist RRP‐Dkk1c eradicates tumors. These tools enable precise pathway control, advancing regenerative and cancer therapies.
Quanhui Dai   +9 more
wiley   +1 more source

AMPK activation by glycogen expenditure primes the exit of naïve pluripotency. [PDF]

open access: yesEMBO Rep
Kim SM   +8 more
europepmc   +1 more source

Upregulation of ST3GAL5 predicts suppression of malignant biological behavior in bladder cancer

open access: yesUroPrecision, EarlyView.
Abstract Background Bladder cancer (BLCA) is the most prevalent malignancy in the urinary tract system, while ST3GAL5 is a protein‐coding gene that catalyzes the formation of ganglioside monosialodihexosylganglioside 3 (GM3) synthase. GM3 synthase has been reported to significantly influence the malignant process of various cancers.
Song Ou‐Yang   +3 more
wiley   +1 more source

Metabolic dysregulation contributes to the development of dysferlinopathy. [PDF]

open access: yesLife Sci Alliance
Furrer R   +7 more
europepmc   +1 more source

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