Results 201 to 210 of about 182,661 (268)

AKAP1 enhances glycogen accumulation and hepatocarcinogenesis through YTHDF2-mediated G6PC mRNA decay. [PDF]

Signal Transduct Target Ther
Yang T, Zhang J, Zhao Z, Cheng S, Yan Z, Wang W, Wang G, Zhang R, Zhang Z, Yuan P, Zheng X, Zhang H, Li J, Xing J.   +13 more
europepmc   +1 more source

LMTK2 Inhibits Metastasis of Colon Cancer Cells Through p38 MAPK

Cancer Science, EarlyView.
LMTK2 suppresses colon cancer metastasis by acting as a kinase‐independent scaffold that directly binds p38, blocking its interaction with MKK3/6 and subsequent phosphorylation, thereby inhibiting the downstream pro‐metastatic gene program. ABSTRACT Metastasis is the leading cause of death in patients with colon cancer. Although Lemur tyrosine kinase 2
Jie Lun, Jinzhao Zhang, Jianxin Xu, Liyuan Jing, Yanqing Qin, Jing Fang, Mengchao Yu   +6 more
wiley   +1 more source

Lauric-acid-rich Hermetia illucens meal modulates lipid metabolism in the liver and the fatty acid profile in piglet tissues. [PDF]

Sci Rep
Szczepanik K, Małgorzata Ś, Piotr D, Oczkowicz M.   +3 more
europepmc   +1 more source

Elucidating PI3K/AKT/PTEN Pathway Alterations at Single‐Cell Level in CTCs From HR+/HER2− Metastatic Breast Cancer

Cancer Science, EarlyView.
Single CTC analysis revealed extensive inter‐ and intra‐patient heterogeneity of PI3K/AKT/PTEN pathway alterations in HR+/HER2− metastatic breast cancer, capturing both SNVs and CNAs, including PTEN loss‐of‐function events. Longitudinal CTC profiling also uncovered dynamic clonal evolution, highlighting its potential to complement tissue and ctDNA ...
Tania Rossi, Michela Palleschi, Caterina Gianni, Filippo Merloni, Alessandra Virga, Sara Bandini, Davide Angeli, Michela Tebaldi, Roberta Maltoni, Paola Ulivi, Antonino Musolino   +10 more
wiley   +1 more source

Synergistic and individual effects of RNase E, II, and R in the regulation of <i>Escherichia coli</i> growth and metabolism. [PDF]

Appl Environ Microbiol
Ramos-Hue M, Audonnet M, Dahmani M, Burck M, Cocaign-Bousquet M, Girbal L.   +5 more
europepmc   +1 more source

Anal Cancer Screening and High‐Resolution Anoscopy: What Surgeons Should Know

ANZ Journal of Surgery, EarlyView.
Matthew Joseph Marino, Benedict Blacket, Richard Clive Turner, Tamzin Cuming, David R. C. James   +4 more
wiley   +1 more source

Genotype‐Informed Whole‐Animal Kinome Screening Reveals Shared Kinase Vulnerabilities Across Driver Contexts in PDAC

Cancer Science, EarlyView.
Overview of experimental workflow and key findings. Clinically prevalent 2‐hit and 3‐hit PDAC genotypes were first modeled in Drosophila to enable kinome‐wide genetic screening. Candidate therapeutic targets were prioritized using human tumor expression data and pathway enrichment analyses.
Han Hai, Takako Ooshio, Hui Jiang, Taku Kimura, Yusuke Satoh, Soichiro Hata, Taiga Hirata, Jiayi Liu, Tongwei Liu, Ryodai Yamamura, Masahiro Sonoshita   +10 more
wiley   +1 more source

Sparing Muscle While Losing Fat: A Narrative Review of Ketogenic Diets and Lean Mass Preservation During Weight Loss. [PDF]

Nutrients
Caturano A, Mocini E, Titi L, Leva F, Cannavaro D, Tarsitano MG, Conte C.   +6 more
europepmc   +1 more source

Assessment of Liver Stiffness in a Rat Model of Type 2 Diabetes Using Shear Wave Elastography. [PDF]

Diagnostics (Basel)
Al-Mutairi FF, Alhashmi MH, Abbas AT, Hazazi MS, Bedaiwi AA, Alamoudi SA, Almoris AH, Albaz RY, Ramadan WS.   +8 more
europepmc   +1 more source

Neonatal gene therapy with AAV2/8-LSPhGAA improves hypertrophic cardiomyopathy in the Gaa^c.1826dupA knock-in murine model. [PDF]

Mol Genet Metab
Kan SH, Harb JF, Li S, Kliman A, Andrade-Heckman P, Christensen CL, Han SO, Koeberl DD, Wang RY.   +8 more
europepmc   +1 more source