Results 61 to 70 of about 245,598 (258)
Advanced Science, EarlyView.CAF‐derived exosomes deliver circFAD104 into TNBC cells, where it acts as a molecular scaffold that bridges the E3 ligase MARCHF8 and PGM1, promoting MARCHF8‐mediated K48‐linked ubiquitination and proteasomal degradation of PGM1. Loss of PGM1 redirects glucose‐phosphate flux from glycogen synthesis toward glycolysis, thereby driving stemness, EMT, and ...
Lei Wang +16 more
wiley +1 more source
Advanced Science, EarlyView.A proof‐of‐concept multifunctional capsule robot integrates diagnostic imaging, magnetic navigation, wireless power transfer, and targeted thermotherapy for gastrointestinal applications. Magnetically guided positioning and stable wireless power enable localized thermal ablation, achieving controlled heating and high cell mortality in vitro.
Heng Zhang +7 more
wiley +1 more source
Patologìâ, 2013 Cardiovascular pathology may be formed on the background of the heart morphogenesis disturbances during fetal development. There is a high prevalence of pathological pregnancy, intrauterine infections of different etiology, accompanied by dysfunction of ...
A. N. Lebedinets
doaj +1 more source
Self‐Assembling Peptide‐Adjuvant Conjugate (SaPAC) Platform for Precision Cancer Immunotherapy
Advanced Science, EarlyView.A self‐assembling peptide–adjuvant conjugate links neoantigens to TLR7 agonism, forming cationic nanoparticles that enhance lymph‐node retention, dendritic‐cell activation, and antitumor T‐cell immunity. This chemically defined platform shows how synchronized antigen and innate stimulation can be adapted across melanoma, bladder cancer, and triple ...
Yang‐Fan Wu +15 more
wiley +1 more source
Molar mass and solution conformation of branched alpha(1 - 4), alpha(1 - 6) Glucans. Part I: Glycogens in water [PDF]
, 2008 Solution molar masses and conformations of glycogens from different sources (rabbit, oyster, mussel and bovine) were analysed using sedimentation velocity in the analytical ultracentrifuge, size-exclusion chromatography coupled to multi-angle laser light
Schafer, B. +13 more
core +1 more source
Advanced Science, EarlyView.Glucocorticoids (GC) are widely used to reduce inflammation. We show that the glucocorticoid receptor in myeloid cells regulates macrophage cell cycle and genome integrity during muscle regeneration. We demonstrate that dexamethasone administration during the early inflammatory phase delays muscle repair by increasing macrophage proliferation ...
Sirine Souali‐Crespo +11 more
wiley +1 more source
Advanced Science, EarlyView.In normal hepatocytes, FBP1 forms compartmentalized complexes with PKM2, ENO1, and LDHA independent of its catalytic activity, inhibiting PKM2 activity and restricting excessive glycolysis. During MASLD progression, FBP1 downregulation markedly reduces the abundance of these complexes and releases the “hijacked” glycolytic enzymes, leading to PKM2 ...
Busong Wang +10 more
wiley +1 more source
Nutrition and exercise determinants of postexercise glycogen synthesis [PDF]
, 1991 During the initial hours of recovery from prolonged exhaustive lower body exercise, muscle glycogen synthesis occurs at rates approximating 1-2 mmol.kg-1 wet wt.hr-1 if no carbohydrate is consumed.
Robergs, Robert A.
core
Advanced Science, EarlyView.Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie +24 more
wiley +1 more source