Results 1 to 10 of about 37,247 (212)

Muscle Glycogen Phosphorylase and Its Functional Partners in Health and Disease [PDF]

Cells, 2021
Glycogen phosphorylase (PG) is a key enzyme taking part in the first step of glycogenolysis. Muscle glycogen phosphorylase (PYGM) differs from other PG isoforms in expression pattern and biochemical properties.
Marta Migocka-Patrzałek, Magdalena Elias   +1 more
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Human hair follicles operate an internal Cori cycle and modulate their growth via glycogen phosphorylase [PDF]

Scientific Reports, 2021
Hair follicles (HFs) are unique, multi-compartment, mini-organs that cycle through phases of active hair growth and pigmentation (anagen), apoptosis-driven regression (catagen) and relative quiescence (telogen).
Katarzyna Figlak, Greg Williams, Marta Bertolini, Ralf Paus, Michael P. Philpott   +4 more
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The role of glycogen phosphorylase in glycogen biogenesis in skeletal muscle after exercise [PDF]

Sports Medicine and Health Science, 2023
Initially it was believed that phosphorylase was responsible for both glycogen breakdown and synthesis in the living cell. The discovery of glycogen synthase and McArdle's disease (lack of phosphorylase activity), together with the high Pi/glucose 1-P ...
Abram Katz
doaj   +2 more sources

Synthesis and Activity Evaluation of Novel Benzoxazepinone Derivatives as Potential Inhibitors of Glycogen Phosphorylase [PDF]

Molecules
Glycogen phosphorylase (GP) is a key enzyme of glycogen catabolism, so it is significant to discover a new GP inhibitor. A series of benzoxazepinone derivatives were identified as glycogen phosphorylase (GP) inhibitors with potent activity.
Dezhi Peng, Youde Wang, Zhiwei Yan, Shuai Li, Yachun Guo, Tienan Wang, Liying Zhang   +6 more
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Brain-Type Glycogen Phosphorylase Is Crucial for Astrocytic Glycogen Accumulation in Chronic Social Defeat Stress-Induced Depression in Mice [PDF]

Frontiers in Molecular Neuroscience, 2022
Astrocytic glycogen plays an important role in brain energy metabolism. However, the contribution of glycogen metabolism to stress-induced depression remains unclear.
Yuanyuan Zhu, Ze Fan, Ze Fan, Qiuying Zhao, Jiaqi Li, Guohong Cai, Rui Wang, Yi Liang, Naining Lu, Junjun Kang, Danlei Luo, Huiren Tao, Yan Li, Jing Huang, Shengxi Wu   +14 more
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Brain-Type Glycogen Phosphorylase (PYGB) in the Pathologies of Diseases: A Systematic Review [PDF]

Cells
Glycogen metabolism is a form of crucial metabolic reprogramming in cells. PYGB, the brain-type glycogen phosphorylase (GP), serves as the rate-limiting enzyme of glycogen catabolism.
Caiting Yang, Haojun Wang, Miaomiao Shao, Fengyu Chu, Yuyu He, Xiaoli Chen, Jiahui Fan, Jingwen Chen, Qianqian Cai, Changxin Wu   +9 more
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Mitochondrial Redox Status Regulates Glycogen Metabolism via Glycogen Phosphorylase Activity [PDF]

Antioxidants
Mitochondria and glycogen are co-distributed in skeletal muscles to regulate the metabolic status. Mitochondria are also redox centers that regulate the muscle function during exercise.
Ikko Sakamoto, Shuichi Shibuya, Hidetoshi Nojiri, Kotaro Takeno, Hiroshi Nishimune, Keisuke Yaku, Takashi Nakagawa, Muneaki Ishijima, Takahiko Shimizu   +8 more
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Manipulating the Expression of Glycogen Phosphorylase in Synechococcus elongatus PCC 7942 to Mobilize Glycogen Storage for Sucrose Synthesis [PDF]

Frontiers in Bioengineering and Biotechnology, 2022
Cyanobacteria are a promising photosynthetic chassis to produce biofuels, biochemicals, and pharmaceuticals at the expense of CO2 and light energy. Glycogen accumulation represents a universal carbon sink mechanism among cyanobacteria, storing excess ...
Yu Dan, Yu Dan, Yu Dan, Jiahui Sun, Jiahui Sun, Jiahui Sun, Jiahui Sun, Shanshan Zhang, Shanshan Zhang, Shanshan Zhang, Shanshan Zhang, Yannan Wu, Yannan Wu, Yannan Wu, Shaoming Mao, Shaoming Mao, Guodong Luan, Guodong Luan, Guodong Luan, Guodong Luan, Xuefeng Lu, Xuefeng Lu, Xuefeng Lu, Xuefeng Lu, Xuefeng Lu   +24 more
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Synthesis, Kinetic and Conformational Studies of 2-Substituted-5-(β-d-glucopyranosyl)-pyrimidin-4-ones as Potential Inhibitors of Glycogen Phosphorylase [PDF]

Molecules, 2020
Dysregulation of glycogen phosphorylase, an enzyme involved in glucose homeostasis, may lead to a number of pathological states such as type 2 diabetes and cancer, making it an important molecular target for the development of new forms of pharmaceutical
Konstantinos F. Mavreas, Dionysios D. Neofytos, Evangelia D. Chrysina, Alessandro Venturini, Thanasis Gimisis   +4 more
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Glycogen Phosphorylase: A Drug Target of Amino Alcohols in Echinococcus granulosus, Predicted by a Computer-Aided Method [PDF]

Frontiers in Microbiology, 2020
Echinococcosis is an important parasitic disease that threats human health and animal husbandry worldwide. However, the low cure rate of clinical drugs for this disease is a challenge. Hence, novel compounds and specific drug targets are urgently needed.
Congshan Liu, Jianhai Yin, Wei Hu, Wei Hu, Haobing Zhang   +4 more
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