Muscle Glycogen Phosphorylase and Its Functional Partners in Health and Disease. [PDF]
Cells, 2021 Glycogen phosphorylase (PG) is a key enzyme taking part in the first step of glycogenolysis. Muscle glycogen phosphorylase (PYGM) differs from other PG isoforms in expression pattern and biochemical properties.
Migocka-Patrzałek M, Elias M.
europepmc +2 more sources
Glycogen Phosphorylase Inhibitor N-(3,5-Dimethyl-Benzoyl)-N’-(β-D-Glucopyranosyl)Urea Improves Glucose Tolerance under Normoglycemic and Diabetic Conditions and Rearranges Hepatic Metabolism [PDF]
PLoS ONE, 2013 Glycogen phosphorylase (GP) catalyzes the breakdown of glycogen and largely contributes to hepatic glucose production making GP inhibition an attractive target to modulate glucose levels in diabetes.
L. Nagy +10 more
semanticscholar +13 more sources
Breast cancers utilize hypoxic glycogen stores via PYGB, the brain isoform of glycogen phosphorylase, to promote metastatic phenotypes. [PDF]
PLoS One, 2019 In breast cancer, tumor hypoxia has been linked to poor prognosis and increased metastasis. Hypoxia activates transcriptional programs in cancer cells that lead to increased motility and invasion, as well as various metabolic changes.
Altemus MA +6 more
europepmc +2 more sources
Old player, new roles: defining the role of the plastidial phosphorylase. [PDF]
New PhytolSummary The plastidial phosphorylase (Pho1 or Phs1; E.C. 2.4.1.1) is a ubiquitous enzyme among plants that catalyzes the formation and degradation of glucans. Although the first report connecting Pho1 with starch metabolism came out > 80 years ago, its precise role is still a matter of debate.
Seung D, Orzechowski S, Fettke J.
europepmc +2 more sources
Glycogen phosphorylase inhibition improves beta cell function. [PDF]
Br J Pharmacol, 2018 Nagy L +14 more
europepmc +2 more sources
C-Glucopyranosyl-1,2,4-triazoles As New Potent Inhibitors of Glycogen Phosphorylase. [PDF]
ACS Medicinal Chemistry Letters, 2013 É. Bokor +3 more
semanticscholar +3 more sources
Action Patterns of Phosphorylase and Glycogen Synthetase on Glycogen [PDF]
European Journal of Biochemistry, 1970 The action patterns of liver and muscle glycogen synthetases and of muscle phosphorylase b on glycogen samples of different molecular weight and on β‐amylase limit dextrins were studied. For this purpose a method for measuring the number of newly added glucose residues that are at non‐reducing ends was developed.It was found that glucose transfer to ...
Parodi, Armando José A. +3 more
openaire +4 more sources
An investigation of acute effects at various doses of malathion on glucose homeostasis and insulin resistance in rat liver, pancreas and serum [PDF]
, 2020 Objective. This study investigates acute effects of various doses of Malathion on glucose homeostasis and insulin resistance in rat. Methods. Rats were randomly divided into four groups of 6 animals each. Corn oil was given orally to Group 1.
Ekremoğlu, Murat +4 more
core +3 more sources
Studies of liver phosphorylase in hepatic injuries. I. Alteration in enzyme activity [PDF]
, 1978 Phosphorylase activities (total and a form) were determined in the livers of experimental hepatic injuries with carbon tetrachloride or galactosamine and the livers of patients with liver diseases.
Kobayashi, Michio
core +1 more source
Lafora disease offers a unique window into neuronal glycogen metabolism [PDF]
, 2018 Lafora disease (LD) is a fatal, autosomal recessive, glycogen-storage disorder that manifests as severe epilepsy. LD results from mutations in the gene encoding either the glycogen phosphatase laforin or the E3 ubiquitin ligase malin. Individuals with LD
Gentry, Matthew S. +4 more
core +2 more sources