Results 51 to 60 of about 128,949 (267)

MGlu5 Dependent Mitochondrial Translocation of PKCδ: A Mechanism Raising Astrocytic Oxidative Metabolism in Response to Extracellular Glutamate

Journal of Neurochemistry, Volume 169, Issue 8, August 2025.
The observations suggest a new mechanism, the mGluR5/PKCδ/PDH axis by which extracellular glutamate can raise oxidative metabolism in astrocytes, in response to rapidly increasing energy demands, such as in the liver or skeletal muscle. It appears that the plethora of astrocytic mitochondria maintain only a basal level of oxidative metabolism during ...
Kiavasch M. N. Farid, Rodrigo Lerchundi, Christine R. Rose, Amin Derouiche   +3 more
wiley   +1 more source

Assay of glycogen phosphorylase by differential spectropolarimetry [PDF]

Analytical Biochemistry, 1971
Abstract A differential spectropolarimetric method has been developed for the measurement of glycogen phosphorylase activity. The reaction course measured in this way was first order, in agreement with results obtained by measuring inorganic phosphate liberation.
Mason, Merle, Fasella, Paolo
openaire   +4 more sources

The origin, hormonal nature, and action of hepatotrophic substances in portal venous blood [PDF]

, 1973
The hepatotrophic factors previously reported to be in splanchnic venous blood are pancreatic hormones and specifically insulin and glucagon. Of these, insulin is anabolic and glucagon is mainly catabolic but not exclusively so, since glucagon also has ...
Brown, TH, Francavilla, A, Francavilla, FR, Halgrimson, CG, Porter, KA, Putnam, CW, Starzl, TE   +6 more
core  

Challenges of drug resistance in the management of pancreatic cancer [PDF]

, 2010
The current treatment of choice for metastatic pancreatic cancer involves single agent gemcitabine or combination of gemcitabine with capecitabine and erlotinib (tyrosine kinase inhibitor).
Akada, Allison, Almoguera, Andreetta, Arai, Arlt, Arteaga, Arumugam, Asano, Bachem, Baldwin, Banerjee, Bartsch, Bergers, Best, Bold, Bondar, Buck, Burris, Chakravarti, Chakravarti, Choi, Cunningham, Cunningham, Dancer, Dong, Duxbury, Duxbury, Duxbury, Duxbury, Engelman, Feldmann, Ferrero, Galmarini, Geyer, Giovannetti, Goan, Greer, Hagmann, Hahn, Henke, Hruban, Humeniuk, Ischenko, Ishikawa, Itoi, Jansen, Karapetis, Kindler, Kong, Koopman, Kulik, Lei, Lemoine, Liau, Liau, Longley, Mackey, Mackey, Mackey, Mahon, Mamaghani, Marechal, Marmor, Martin Clynes, Mata, Maxwell, Mendelsohn, Meropol, Miwa, Moertel, Molina-Arcas, Moore, Morgillo, Moriyama, Muerkoster, Muerkoster, Nakahira, Nakajima, Nakano, Naomi Walsh, Nishimura, Oguri, Okamoto, Okumura, Olive, O’Driscoll, Pao, Park, Park, Peters, Plunkett, Ray McDermott, Ritzel, Rizwan Sheikh, Robert O’Connor, Ruggeri, Safran, Saito, Sakamoto, Schuller, Sebastiani, Shah, Shi, Simon, Spratlin, Takao, Takebayashi, Treat, Tsukamoto, Tzeng, Vaishampayan, Van Cutsem, van der Wilt, Wang, Wang, Wang, Xiong, Yamasaki, Yokoi   +119 more
core   +1 more source

How to Reproduce in the Siberian Winter: Proteome Dynamics Reveals the Timing of Reproduction‐Related Processes in an Amphipod Species Endemic to Lake Baikal

Ecology and Evolution, Volume 15, Issue 7, July 2025.
The vast Lake Baikal in Siberia is located in a region with a continental climate, implying pronounced seasonal temperature differences. Remarkably, reproducing during the extremely cold winters when the lake is covered by a thick ice layer is a common trait in Baikal's endemic littoral amphipods.
Polina Lipaeva, Polina Drozdova, Kseniya Vereshchagina, Lena Jakob, Kristin Schubert, Daria Bedulina, Till Luckenbach   +6 more
wiley   +1 more source

Glycogenin is Dispensable for Glycogen Synthesis in Human Muscle, and Glycogenin Deficiency Causes Polyglucosan Storage [PDF]

, 2020
Glycogenin is considered to be an essential primer for glycogen biosynthesis. Nevertheless, patients with glycogenin-1 deficiency due to biallelic GYG1 (NM_004130.3) mutations can store glycogen in muscle.
Dellgren, Göran, Glamuzina, Emma, Hedberg-Oldfors, Carola, Hernandez-Lain, Aurelio, Kornblum, Cornelia, Oldfors, Anders, Roach, Peter, Sandstedt, Joakim, Tasca, Giorgio, Thomsen, Christer, Visuttijai, Kittichate   +10 more
core   +1 more source

Exploring Astragaloside IV in Ischemic Heart Disease: A Comprehensive Systematic Review and Meta‐Analysis of Preclinical Cardiotoxicity Models

Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 7, July 2025.
This systematic review and meta‐analysis evaluated the therapeutic efficacy of Astragaloside IV in ischemic heart disease, encompassing 18 preclinical studies. The findings demonstrated that As‐IV significantly reduced myocardial infarction size and apoptosis while improving cardiac function and angiogenesis through various mechanisms, along with ...
Alosh Greeny, Gollapalle Lakshminarayanashastry Viswanatha, Rekha Raghuveer Shenoy, Shylaja Hanumanthappa, Dinesh Kumar Chellappan, Jagnoor Singh Sandhu, Saumya Khanna, Nandakumar Krishnadas   +7 more
wiley   +1 more source

Cargo Analysis and MRI‐Based Therapeutic Assessment of Iron Oxide Labelled Extracellular Vesicles of Hypoxia Human Stem Cells in Ischemic Stroke

Journal of Extracellular Biology, Volume 4, Issue 7, July 2025.
ABSTRACT Human mesenchymal stem cells (hMSCs) have been under investigation in preclinical and clinical settings for treating neurological disorders in recent years. Predominantly due to paracrine effects in vivo, hMSC‐secreted extracellular vesicles (EVs) are at the forefront of these investigations.
Shannon Helsper, Li Sun, Richard Jeske, Chang Liu, Jacob Athey, Xuegang Yuan, Samuel C. Grant, Yan Li   +7 more
wiley   +1 more source

Speed Endurance Training to Improve Performance

Scandinavian Journal of Medicine &Science in Sports, Volume 35, Issue 7, July 2025.
ABSTRACT In many sports, the physical dimension plays a crucial role in determining athletic performance. This review provides insights into the effectiveness of speed endurance training (SET), that is, exercise training performed at intensities higher than that eliciting maximum oxygen uptake (V̇O2‐max), on performance across different sports and ...
Jens Bangsbo, Julie Kissow, Morten Hostrup   +2 more
wiley   +1 more source

LIVER TRANSPLANTATION FOR TYPE I GLYCOGEN STORAGE DISEASE [PDF]

, 1983
A 16½-year-old girl with type I glycogen storage disease was treated by orthotopic liver transplantation under cyclosporin/steroid immunosuppression. All metabolic stigmata of the disease were relieved and 1 year postoperatively she follows a normal diet
Alper, Alper Ca, Con, Folkman, Greene, Greene, Kashiwagi, Kashiwagi, Merrill, Nordlie, Raum, Starzl, Starzl, Starzl, Starzl, Starzl   +15 more
core   +1 more source