Results 181 to 190 of about 67,076 (344)

Revealing the Diverse Allergenic Protein Repertoire of Six Widely Consumed Crab Species: A Species‐Specific Allergen in King Crab

Allergy, EarlyView.
This study comprehended the allergen profiles of six edible crab species using proteomic and transcriptomic analyses and identified 11 putative allergens. King crab has a distinct protein and allergen profile, with the discovery of malate dehydrogenase as a novel king crab‐specific allergen registered as Para c 11.
Shanshan Li, Jingyuan Bian, Qing Xiong, Brian Shing‐Hei Wong, Stephen Kwok‐Wing Tsui, Kin‐Ming Kwan, Nicki Yat‐Hin Leung, Ting‐Fan Leung, Patrick S. C. Leung, Ka‐Hou Chu, Xiaojun Xiao, Christine Yee‐Yan Wai   +11 more
wiley   +1 more source

A non‐hormonal reversible contraceptive targeting GSK3α, a protein kinase, essential for epididymal sperm maturation

Andrology, EarlyView.
Abstract Background and objectives Epididymal transit renders key competence to mammalian spermatozoa for fertilizing eggs. Generally, the two paralogs of glycogen synthase kinase 3, GSK3α and GSK3β, functionally overlap except in testis and sperm. We showed that GSK3α is essential for epididymal sperm maturation and fertilization.
Mustfa Kabi, Aditi Khamamkar, Kwaku Kyei‐Baffour, Michel Weïwer, Srinivasan Vijayaraghavan, Souvik Dey   +5 more
wiley   +1 more source

Glycogen Storage Disease Type I (Von Gierke disease): Report of Two Cases with Severe Dyslipidemia. [PDF]

Arq Bras Cardiol, 2020
Ballavenuto JMA, Oliveira JDÓD, Alves RJ.   +2 more
europepmc   +1 more source

Assessment of the molecular mechanisms of drug‐induced hidden cardiotoxicity by a multi‐omics approach: The example of rofecoxib

British Journal of Pharmacology, EarlyView.
Background and Purpose Hidden cardiotoxicity is defined as drug‐induced cardiotoxicity that becomes obvious only in the presence of comorbidities. However, the molecular mechanisms of hidden cardiotoxicity are not always known. Therefore, unbiased multi‐omics approaches could assist in revealing regulatory pathways.
Bennet Y. Weber, Gábor B. Brenner, Barnabás Váradi, Bence Ágg, Csenger Kovácsházi, Olivér M. Balogh, Donagh Egan, Kieran Wynne, David Matallanas, Rainer Schulz, Péter Ferdinandy, Zoltán Giricz, Anikó Görbe   +12 more
wiley   +1 more source

A novel 2.4‐kb PHKA2 deletion in a boy with glycogen storage disease type IXa [PDF]

Takeshi Sato, Yosuke Ichihashi, Hideo Sugie, Tomohiro Ishii, Tomonobu Hasegawa   +4 more
openalex   +1 more source

Maternal Nutritional Status Governs Fetal Development by Modulating Imprinting Gene GAB1‐Mediated Trophoblast Differentiation in the Placenta

Cell Proliferation, EarlyView.
Maternal nutrient restriction disrupts placental homeostasis via GAB1 dysregulation—involving both transcriptional downregulation and autophagy‐dependent protein degradation. These molecular alterations inhibit MAPK signalling‐mediated trophoblast fusion, leading to structural and functional deficits in the maternal–fetal exchange interface.
Mingming Fan, Hongyu Wu, Yuan Xie, Ming Liu, Xin Yu, Feiyang Wang, Zhenyu Xiao, Hongmei Wang, Xuan Shao, Yan‐Ling Wang   +9 more
wiley   +1 more source

A patient with glycogen storage disease type 0 and a novel sequence variant in GYS2: a case report and literature review [PDF]

, 2020
Janez Jan Arko, Maruša Debeljak, Mojca Žerjav Tanšek, Tadej Battelino, Urh Grošelj   +4 more
openalex   +1 more source

Development of NAFLD‐Specific Human Liver Organoid Models on a Microengineered Array Chip for Semaglutide Efficacy Evaluation

Cell Proliferation, EarlyView.
Microporous array organ chips were integrated with commercially available well plates to develop organoid chip platforms, which enable modelling of hepatic physiology and non‐alcoholic fatty liver disease (NAFLD) pathogenesis, as well as evaluation of semaglutide therapeutics. ABSTRACT Progressive non‐alcoholic fatty liver disease (NAFLD) may culminate
Xiao‐yan You, Xiang‐yang Li, Hui Wang, Guo‐ping Zhao   +3 more
wiley   +1 more source

Glycolysis and Lipogenesis in the Livers form Children with Type I of Glycogen Storage Disease

, 1963
Keiya Tada, Tasuke Shibuya, Jinzo Akabane   +2 more
openalex   +2 more sources

Cardioprotective effects of the extracellular chaperone clusterin in acute myocardial infarction

European Journal of Clinical Investigation, EarlyView.
In vivo, CLU−/− mice were more susceptible to acute myocardial infarction than CLU+/+ mice. Moreover, inflammation and histone levels were significantly increased in CLU−/− mice compared to CLU+/+ mice following ischemia/reperfusion. In vitro, CLU protects cardiomyocytes from histone‐ and/or hypoxia‐induced cell death.
Louwana Allawa, Antoine Poirier, Pascale Pignon, Justine Beaumont, Lucie Lebeau, Agnès Barbelivien, Thomas Bochaton, Céline Beauvillain, Daniel Henrion, Yves Delneste, Pascale Jeannin, Fabrice Prunier, Sophie Tamareille   +12 more
wiley   +1 more source