Results 41 to 50 of about 76,168 (194)
ORM Promotes Skeletal Muscle Glycogen Accumulation via CCR5-Activated AMPK Pathway in Mice
Frontiers in Pharmacology, 2016 We found previously that acute phase protein orosomucoid reacts to fatigue and activates C-C chemokine receptor type 5 to increase muscle glycogen storage and enhance muscle endurance (Lei et al., 2016). To explore the underlying molecular mechanisms, we
Zhen Qin +6 more
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Heliyon, 2023 Background: High fructose diet has been linked with impaired body metabolism and cardiovascular diseases. Sodium butyrate (NaB) was documented to improve glucoregulation and cardiometabolic problems associated with high fructose diet (HFrD) but the ...
Adewumi Oluwafemi Oyabambi +3 more
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Journal of Parasitology Research, 2015 Trehalose and glycogen metabolism plays an important role in supporting life processes in many nematodes, including Anisakis simplex. Nematodes, cosmopolitan helminths parasitizing sea mammals and humans, cause a disease known as anisakiasis.
E. Łopieńska-Biernat +2 more
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High-affinity binding of glycogen-synthase phosphatase to glycogen particles in the liver. Role of glycogen in the inhibition of synthase phosphatase by phosphorylase a [PDF]
Biochemical Journal, 1987 1. Post-mitochondrial supernatants were prepared from the livers of 24 h-fasted rats. Upon centrifugation at high speed, the major part of the glycogen-synthase phosphatase activity sedimented with the microsomal fraction. However, two approaches showed that the enzyme was associated with residual glycogen rather than with vesicles of the endoplasmic ...
Willy Stalmans, Lelo Mvumbi
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Deleterious effects of neuronal accumulation of glycogen in flies and mice
EMBO Molecular Medicine, 2012 Under physiological conditions, most neurons keep glycogen synthase (GS) in an inactive form and do not show detectable levels of glycogen. Nevertheless, aberrant glycogen accumulation in neurons is a hallmark of patients suffering from Lafora disease or
Jordi Duran +5 more
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Structural basis for 2′-phosphate incorporation into glycogen by glycogen synthase [PDF]
Proceedings of the National Academy of Sciences, 2013 Significance Glycogen is a branched glucose polymer found in most animals, fungi, bacteria, and archaea as an osmotically neutral means of energy storage. Glycogen also contains minor amounts of phosphate which can be removed by a dual specificity phosphatase, laforin.
Anna A. DePaoli-Roach +8 more
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In vivo regulation of muscle glycogen synthase and the control of glycogen synthesis. [PDF]
Proceedings of the National Academy of Sciences, 1995 The activity of glycogen synthase (GSase; EC 2.4.1.11) is regulated by covalent phosphorylation. Because of this regulation, GSase has generally been considered to control the rate of glycogen synthesis. This hypothesis is examined in light of recent in vivo NMR experiments on rat and human muscle and is found to be quantitatively inconsistent with the
Robert G. Shulman +2 more
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Frontiers in Physiology, 2019 Harmonia axyridis is an important predatory insect and widely used in biological control of agricultural and forestry pests. Trehalose is directly involved in the energy storage of the H.
Yan Li +6 more
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BMC Neuroscience, 2004 Background Lithium, a mood stabilizer widely used to treat bipolar disorder, also is a neuroprotectant, providing neurons protection from apoptosis induced by a broad spectrum of toxic conditions.
Jope Richard S, Zhou Tong, Song Ling
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Glycogen Synthase Kinase–3 and the Heart∗
Journal of the American College of Cardiology, 2014 Over the past decade, optimism has been high for the potential clinical significance of glycogen synthase kinase–3 (GSK-3) as a pharmacological target for ischemia and heart failure, as well as diabetes, Parkinson’s disease, and Alzheimer’s disease.
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