Results 51 to 60 of about 76,168 (194)
Journal of Functional Foods, 2012 Tumour necrosis factor-α (TNF-α) plays a pivotal role in cellular insulin resistance and can induce insulin resistance in mouse FL83B hepatocytes. Caffeic acid and cinnamic acid were found to improve glucose uptake in TNF-α-treated insulin-resistant ...
Da-Wei Huang, Szu-Chuan Shen
doaj
Sediment pollutant exposures caused hepatotoxicity and disturbed glycogenesis
Ecotoxicology and Environmental Safety, 2023 Liver metabolic syndrome, which involves impaired hepatic glycogen synthesis, is persistently increased by exposure to environmental pollutants. Most studies have investigated the pathogenesis of liver damage caused by single metal species or pure ...
Meng-Wei Lin +11 more
doaj
The structural mechanism of human glycogen synthesis by the GYS1-GYG1 complex
Cell Reports, 2022 Summary: Glycogen is the primary energy reserve in mammals, and dysregulation of glycogen metabolism can result in glycogen storage diseases (GSDs). In muscle, glycogen synthesis is initiated by the enzymes glycogenin-1 (GYG1), which seeds the molecule ...
Nathan M. Fastman +12 more
doaj
Effects of starvation on the carbohydrate metabolism in Harmonia axyridis (Pallas)
Biology Open, 2017 Trehalose plays an important role in energy storage, metabolism, and protection from extreme environmental conditions in insects. Trehalose is the main blood sugar in insects, and it can be rapidly used as an energy source in times of need.
Zuo-Kun Shi +7 more
doaj +1 more source
Glycogen is a neutral cargo of bulk autophagy in Komagataella phaffii
Autophagy ReportsGlycogen is a primary cellular energy store in numerous eukaryotes. Its biosynthesis is a main strategy to cope with forthcoming starvation. During starvation, glycogen is processed in the cytosol or delivered for degradation to animal lysosomes or yeast
Nimna V. Wijewantha, Taras Y. Nazarko
doaj +1 more source
Redox Biology, 2022 Vitamin C (VC, l-ascorbic acid) is an essential nutrient that plays a key role in metabolism and functions as a potent antioxidant in regulating the S-nitrosylation and denitrosylation of target proteins. The precise function of VC deprivation in glucose
Yingying Shu +10 more
doaj
Amaryllidaceae Alkaloids as Potential Glycogen Synthase Kinase-3β Inhibitors
Molecules, 2018 Glycogen synthase kinase-3β (GSK-3β) is a multifunctional serine/threonine protein kinase that was originally identified as an enzyme involved in the control of glycogen metabolism.
Daniela Hulcová +9 more
doaj +1 more source
The effect of insulin on the glycogenolytic cascade and on the activity of glycogen synthase in the liver of anaesthetized rabbits [PDF]
, 1977 G van de Werve, Willy Stalmans, H G Hers
openalex +1 more source
Calmodulin-dependent glycogen synthase kinase.
Journal of Biological Chemistry, 1980 A cAMP-independent glycogen synthase kinase has been purified from rabbit liver. This kinase is completely dependent on the presence of calmodulin and Ca2+ for activity. Half-maximal activation required about 0.1 microM calmodulin. Complete inhibition was obtained in the presence of ethylene glycol bis(beta-aminoethyl ether)N,N,N',N'-tetraacetic acid ...
M E Payne, T R Soderling
openaire +3 more sources
Research advances of glycogen synthetic kinase-3β in diabetic nephropathy
Linchuang shenzangbing zazhi, 2021 The pathogenesis of diabetic kidney disease（DKD）is rather complicated.And glycogen synthase-3 plays important roles in many signaling pathways in body.For chronic kidney injury caused by diabetes, it is involved in the damage process of glomerular ...
He Zhi-xiu, Ma Chan-juan
doaj