Huddling alleviates the decrease in glycogen and lipid content in the liver of Brandt’s vole caused by mild cold environment [PDF]
Zoologia (Curitiba)Low/cold ambient temperatures can induce hepatic damage in mammals, prompting the evolution of huddling as an adaptive strategy among small mammals to survive cold conditions in the wild.
Jin-Hui Xu +6 more
doaj +1 more source
Unambiguous tracking of protein phosphorylation by fast, high-resolution FOSY NMR [PDF]
arXiv, 2021 Phosphorylation is a prototypical example of post-translational modifications (PTMs) that dynamically modulate protein func-tion, where dysregulation is often implicated in disease. NMR provides information on the exact location and time course of PTMs with atomic resolution and under nearly physiological conditions, including inside living cells, but ...
arxiv
Quantification of the glycogen cascade system: the ultrasensitive responses of liver glycogen synthase and muscle phosphorylase are due to distinctive regulatory designs [PDF]
, 2005 BACKGROUND: Signaling pathways include intricate networks of reversible covalent modification cycles. Such multicyclic enzyme cascades amplify the input stimulus, cause integration of multiple signals and exhibit sensitive output responses. Regulation of
Mutalik, Vivek K, Venkatesh, KV
core +3 more sources
Glycogen synthase kinase‐3β is a pivotal mediator of cancer invasion and resistance to therapy
Cancer Science, 2016 Tumor cell invasion and resistance to therapy are the most intractable biological characteristics of cancer and, therefore, the most challenging for current cancer research and treatment paradigms.
Takahiro Domoto +7 more
semanticscholar +1 more source
The Turkish Journal of Pediatrics, 2018 Glycogen storage disease type 0 (GSD0) has been considered a rare disorder, it is characterized with ketotic hypoglycemia after prolonged fasting and postprandial hyperglycemia.
Bülent Hacıhamdioğlu +4 more
doaj +1 more source
Molecular basis of impaired glycogen metabolism during ischemic stroke and hypoxia. [PDF]
PLoS ONE, 2014 BACKGROUND: Ischemic stroke is the combinatorial effect of many pathological processes including the loss of energy supplies, excessive intracellular calcium accumulation, oxidative stress, and inflammatory responses.
Mohammed Iqbal Hossain +2 more
doaj +1 more source
Glycogen Synthase Kinase-3 (GSK-3)-Targeted Therapy and Imaging
Theranostics, 2016 Glycogen synthase kinase-3 (GSK-3) is associated with various key biological processes, including glucose regulation, apoptosis, protein synthesis, cell signaling, cellular transport, gene transcription, proliferation, and intracellular communication ...
M. Pandey, T. DeGrado
semanticscholar +1 more source
Gut microbiota‐stem cell niche crosstalk: A new territory for maintaining intestinal homeostasis
iMeta, Volume 1, Issue 4, December 2022., 2022 Intestinal stem cells (ISCs) are protected by their niche and are regulated by Wnt, bone morphogenetic protein, and Notch. ISCs and their relationship with intestinal microbiota provide a feasible pathway to alleviate intestinal diseases. Diverse bacteria‐related postbiotics regulate ISCs and maintain their homeostasis.
Ning Ma +3 more
wiley +1 more source
Hypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1. [PDF]
PLoS ONE, 2010 When oxygen becomes limiting, cells reduce mitochondrial respiration and increase ATP production through anaerobic fermentation of glucose. The Hypoxia Inducible Factors (HIFs) play a key role in this metabolic shift by regulating the transcription of ...
Nuria Pescador +12 more
doaj +1 more source
Morphological analysis of CDC2 and glycogen synthase kinase 3β phosphorylation as markers of g2 → m transition in glioma. [PDF]
, 2011 G2 → M transition is a strategic target for glioma chemotherapy. Key players in G2 → M transition include CDC2 and glycogen synthase kinase 3β (GSK3β), which are highly regulated by posttranslational phosphorylation.
Otero, José Javier, Tihan, Tarik
core +3 more sources