Results 11 to 20 of about 46,712 (217)

Development of a Self-Adjuvanting Influenza Peptide-Glycolipid Conjugate Inducing CD8⁺ T-Cell Immunity. [PDF]

Chembiochem
The glycolipid‐peptide antigen complexes for self‐adjuvanting conjugates were successfully synthesized, and, with the HLA‐transgenic mice, the antigen‐specific CD8+ T cell expansion was exhibited. The results provide useful insights for the design and synthesis of vaccine conjugates using glycolipid antigen as an adjuvant.
Kikuchi S, Ogura H, Matsumaru T, Ishido S, Fujimoto Y.   +4 more
europepmc   +2 more sources

Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Abstract Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of obesity and NASH. Approach and Results Intestinal PPARα was activated and fatty
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez   +22 more
wiley   +1 more source

Analysis of glycosylinositol phosphorylceramides expressed by the opportunistic mycopathogen Aspergillus fumigatus s⃞

Journal of Lipid Research, 2007
Acidic glycosphingolipid components were extracted from the opportunistic mycopathogen Aspergillus fumigatus and identified as inositol phosphorylceramide and glycosylinositol phosphorylceramides (GIPCs).
Marcos S. Toledo, Steven B. Levery, Beau Bennion, Luciana L. Guimaraes, Sherry A. Castle, Rebecca Lindsey, Michelle Momany, Chaeho Park, Anita H. Straus, Helio K. Takahashi   +9 more
doaj   +1 more source

Chloride Ions Are Required for Thermosipho africanus MurJ Function

mBio, 2023
Most bacteria have a peptidoglycan cell wall that determines their cell shape and helps them resist osmotic lysis. Peptidoglycan synthesis depends on the translocation of the lipid-linked precursor lipid II across the cytoplasmic membrane by the MurJ ...
Sujeet Kumar, Aurelio Mollo, Frederick A. Rubino, Daniel Kahne, Natividad Ruiz   +4 more
doaj   +1 more source

A Glycolipid α-GalCer Derivative, 7DW8-5 as a Novel Mucosal Adjuvant for the Split Inactivated Influenza Vaccine

Viruses, 2022
Influenza virus infects the host and transmits through the respiratory tract (i.e., the mouth and nose); therefore, the development of intranasal influenza vaccines that mimic the natural infection, coupled with an efficient mucosal adjuvant, is an ...
Huapeng Feng, Ruolin Sun, Guanru Song, Shunfan Zhu, Zhenyu Nie, Liming Lin, Ruonan Yi, Shixiang Wu, Genzhu Wang, Yulong He, Siquan Wang, Pei Wang, Li Wu, Jianhong Shu   +13 more
doaj   +1 more source

Lipoarabinomannan in Active and Passive Protection Against Tuberculosis

Frontiers in Immunology, 2019
Glycolipids of the cell wall of Mycobacterium tuberculosis (Mtb) are important immunomodulators in tuberculosis. In particular, lipoarabinomannan (LAM) has a profound effect on the innate immune response. LAM and its structural variants can be recognized
Margarida Correia-Neves, Margarida Correia-Neves, Margarida Correia-Neves, Christopher Sundling, Christopher Sundling, Andrea Cooper, Gunilla Källenius   +6 more
doaj   +1 more source

Amadori-glycated phosphatidylethanolamine enhances the physical stability and selective targeting ability of liposomes [PDF]

Royal Society Open Science, 2018
Liposomes consisting of 100% phosphatidylcholine exhibit poor membrane fusion, cellular uptake and selective targeting capacities. To overcome these limitations, we used Amadori-glycated phosphatidylethanolamine, which is universally present in animals ...
Taiki Miyazawa, Reina Kamiyoshihara, Naoki Shimizu, Takahiro Harigae, Yurika Otoki, Junya Ito, Shunji Kato, Teruo Miyazawa, Kiyotaka Nakagawa   +8 more
doaj   +1 more source

The ABC Transporter Components HgdB and HgdC are Important for Glycolipid Layer Composition and Function of Heterocysts in Anabaena sp. PCC 7120

Life, 2018
Anabaena sp. PCC 7120 is a filamentous cyanobacterium able to fix atmospheric nitrogen in semi-regularly spaced heterocysts. For correct heterocyst function, a special cell envelope consisting of a glycolipid layer and a polysaccharide layer is essential.
Dmitry Shvarev, Carolina N. Nishi, Lars Wörmer, Iris Maldener   +3 more
doaj   +1 more source

Glycosphingolipids of the model fungus Aspergillus nidulans

Journal of Lipid Research, 2003
Aspergillus nidulans is a well-established nonpathogenic laboratory model for the opportunistic mycopathogen, A. fumigatus. Some recent studies have focused on possible functional roles of glycosphingolipids (GSLs) in these fungi.
Beau Bennion, Chaeho Park, Matthew Fuller, Rebecca Lindsey, Michelle Momany, Richard Jennemann, Steven B. Levery   +6 more
doaj   +1 more source

Characterization of Leishmania (Viannia) braziliensis membrane microdomains, and their role in macrophage infectivity

Journal of Lipid Research, 2006
Detergent-resistant membranes (DRMs) from Leishmania (Viannia) braziliensis promastigotes, insoluble in 1% Triton X-100 at 4°C, were fractionated by sucrose density gradient ultracentrifugation.
Kelly A.G. Yoneyama, Ameria K. Tanaka, Thais G.V. Silveira, Helio K. Takahashi, Anita H. Straus   +4 more
doaj   +1 more source