Results 11 to 20 of about 81,425 (291)

Sulfated Lactosyl Archaeol Archaeosomes Synergize with Poly(I:C) to Enhance the Immunogenicity and Efficacy of a Synthetic Long Peptide-Based Vaccine in a Melanoma Tumor Model

Pharmaceutics, 2021
Cancer remains a leading cause of morbidity and mortality worldwide. While novel treatments have improved survival outcomes for some patients, new treatment modalities/platforms are needed to combat a wider variety of tumor types. Cancer vaccines harness
Bassel Akache, Gerard Agbayani, Felicity C. Stark, Yimei Jia, Renu Dudani, Blair A. Harrison, Lise Deschatelets, Vandana Chandan, Edmond Lam, Usha D. Hemraz, Sophie Régnier, Lakshmi Krishnan, Michael J. McCluskie   +12 more
doaj   +1 more source

Functions of CD1d-Restricted Invariant Natural Killer T Cells in Antimicrobial Immunity and Potential Applications for Infection Control

Frontiers in Immunology, 2018
CD1d-restricted invariant natural killer T (iNKT) cells are innate-type lymphocytes that express a T-cell receptor (TCR) containing an invariant α chain encoded by the Vα14 gene in mice and Vα24 gene in humans.
Yuki Kinjo, Shogo Takatsuka, Naoki Kitano, Shun Kawakubo, Masahiro Abe, Keigo Ueno, Yoshitsugu Miyazaki   +6 more
doaj   +1 more source

Galactosylsphingamides : new α-GalCer analogues to probe the F’-pocket of CD1d [PDF]

, 2017
Invariant Natural Killer T-cells (iNKT-cells) are an attractive target for immune response modulation, as upon CD1d-mediated stimulation with KRN7000, a synthetic alpha-galactosylceramide, they produce a vast amount of cytokines.
Decruy, Tine, Elewaut, Dirk, Froeyen, Mathy, Guillaume, Joren, Janssens, Jonas, Remesh, Soumya G, Risseeuw, Martijn, Van Calenbergh, Serge, Wang, Jing, Zajonc, Dirk M   +9 more
core   +1 more source

Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barré Syndrome in Brazil. [PDF]

, 2019
Zika virus infection is associated with the development of Guillain-Barré syndrome (GBS), a neurological autoimmune disorder caused by immune recognition of gangliosides and other components at nerve membranes.
Alcantara, Luiz Carlos Junior, de Siqueira, Isadora Cristina, do Rosário, Mateus Santana, Ernst, Joel D, Mota, Sabrina, Pereira de Jesus, Pedro Antônio, Rivera-Correa, Juan, Rodriguez, Ana   +7 more
core   +1 more source

Analysis of glycosylinositol phosphorylceramides expressed by the opportunistic mycopathogen Aspergillus fumigatus s⃞

Journal of Lipid Research, 2007
Acidic glycosphingolipid components were extracted from the opportunistic mycopathogen Aspergillus fumigatus and identified as inositol phosphorylceramide and glycosylinositol phosphorylceramides (GIPCs).
Marcos S. Toledo, Steven B. Levery, Beau Bennion, Luciana L. Guimaraes, Sherry A. Castle, Rebecca Lindsey, Michelle Momany, Chaeho Park, Anita H. Straus, Helio K. Takahashi   +9 more
doaj   +1 more source

Chloride Ions Are Required for Thermosipho africanus MurJ Function

mBio, 2023
Most bacteria have a peptidoglycan cell wall that determines their cell shape and helps them resist osmotic lysis. Peptidoglycan synthesis depends on the translocation of the lipid-linked precursor lipid II across the cytoplasmic membrane by the MurJ ...
Sujeet Kumar, Aurelio Mollo, Frederick A. Rubino, Daniel Kahne, Natividad Ruiz   +4 more
doaj   +1 more source

An in silico approach for modelling T-helper polarizing iNKT cell agonists [PDF]

, 2014
Many analogues of the glycolipid alpha-galactosylceramide (α-GalCer) are known to activate iNKT cells through their interaction with CD1d-expressing antigen-presenting cells, inducing the release of Th1 and Th2 cytokines. Because of iNKT cell involvement
ASPESLAGH, SANDRINE, Boucart, Maxime, De Spiegeleer, Anton, Elewaut, Dirk, Stalmans, Sofie, Van Calenbergh, Serge, Van Den Noortgate, Nele, Vandekerckhove, Matthias, Venken, Koen, Wynendaele, Evelien   +9 more
core   +3 more sources

A Glycolipid α-GalCer Derivative, 7DW8-5 as a Novel Mucosal Adjuvant for the Split Inactivated Influenza Vaccine

Viruses, 2022
Influenza virus infects the host and transmits through the respiratory tract (i.e., the mouth and nose); therefore, the development of intranasal influenza vaccines that mimic the natural infection, coupled with an efficient mucosal adjuvant, is an ...
Huapeng Feng, Ruolin Sun, Guanru Song, Shunfan Zhu, Zhenyu Nie, Liming Lin, Ruonan Yi, Shixiang Wu, Genzhu Wang, Yulong He, Siquan Wang, Pei Wang, Li Wu, Jianhong Shu   +13 more
doaj   +1 more source

Retrograde transport pathways utilised by viruses and protein toxins [PDF]

, 2006
A model has been presented for retrograde transport of certain toxins and viruses from the cell surface to the ER that suggests an obligatory interaction with a glycolipid receptor at the cell surface. Here we review studies on the ER trafficking cholera
Easton, A. J. (Andrew J.), Lord, Mike, Roberts, L. M. (Lynne M.), Smith, Daniel C., Spooner, Robert A.   +4 more
core   +2 more sources

Oral Protein Therapy for the Future - Transport of Glycolipid-Modified Proteins: Vision or Fiction? [PDF]

, 2010
The reliable and early diagnosis of common complex multifactorial diseases depends on the individual determination of all (or as many as possible) polymorphisms of each susceptibility gene together with amount and type of the corresponding gene products ...
Mueller, Guenter
core   +1 more source