Results 21 to 30 of about 10,062 (222)

Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Abstract Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of obesity and NASH. Approach and Results Intestinal PPARα was activated and fatty
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez   +22 more
wiley   +1 more source

The ABC Transporter Components HgdB and HgdC are Important for Glycolipid Layer Composition and Function of Heterocysts in Anabaena sp. PCC 7120

Life, 2018
Anabaena sp. PCC 7120 is a filamentous cyanobacterium able to fix atmospheric nitrogen in semi-regularly spaced heterocysts. For correct heterocyst function, a special cell envelope consisting of a glycolipid layer and a polysaccharide layer is essential.
Dmitry Shvarev, Carolina N. Nishi, Lars Wörmer, Iris Maldener   +3 more
doaj   +1 more source

Glycosphingolipids of the model fungus Aspergillus nidulans

Journal of Lipid Research, 2003
Aspergillus nidulans is a well-established nonpathogenic laboratory model for the opportunistic mycopathogen, A. fumigatus. Some recent studies have focused on possible functional roles of glycosphingolipids (GSLs) in these fungi.
Beau Bennion, Chaeho Park, Matthew Fuller, Rebecca Lindsey, Michelle Momany, Richard Jennemann, Steven B. Levery   +6 more
doaj   +1 more source

Glycolipid transfer proteins and membrane interaction [PDF]

, 2009
The glycolipid transfer protein is found from animals and fungi to plants and red micro-alga. Some eukaryotes that do not encode the glucosylceramide synthase like the yeast Schizosaccharomyces pombe and Saccharomyces cerevisiae do neither produce ...
Mattjus, Peter
core   +1 more source

Characterization of Leishmania (Viannia) braziliensis membrane microdomains, and their role in macrophage infectivity

Journal of Lipid Research, 2006
Detergent-resistant membranes (DRMs) from Leishmania (Viannia) braziliensis promastigotes, insoluble in 1% Triton X-100 at 4°C, were fractionated by sucrose density gradient ultracentrifugation.
Kelly A.G. Yoneyama, Ameria K. Tanaka, Thais G.V. Silveira, Helio K. Takahashi, Anita H. Straus   +4 more
doaj   +1 more source

A Glycolipid Adjuvant, 7DW8-5, Enhances the Protective Immune Response to the Current Split Influenza Vaccine in Mice

Frontiers in Microbiology, 2019
Vaccination is an effective strategy to control influenza disease. Adjuvants enhance the efficacy of vaccines, but few adjuvants are approved for human use, so novel, safe, and effective adjuvants are urgently needed.
Huapeng Feng, Noriko Nakajima, Li Wu, Makoto Yamashita, Tiago J. S. Lopes, Moriya Tsuji, Hideki Hasegawa, Tokiko Watanabe, Yoshihiro Kawaoka, Yoshihiro Kawaoka, Yoshihiro Kawaoka   +10 more
doaj   +1 more source

Structure Elucidation and Characterization of Novel Glycolipid Biosurfactant Produced by Rouxiella badensis DSM 100043^T

Molecules
Microbial biosurfactants have become increasingly attractive as promising ingredients for environmentally friendly products. The reasons for this are their generally good performance and biodegradability, low toxicity, production from renewable raw ...
Andre Fahriz Perdana Harahap, Jürgen Conrad, Mario Wolf, Jens Pfannstiel, Iris Klaiber, Jakob Grether, Eric Hiller, Maliheh Vahidinasab, Hanna Salminen, Chantal Treinen, Elvio Henrique Benatto Perino, Rudolf Hausmann   +11 more
doaj   +1 more source

Determination of lipid-bound sulfate by ion chromatography and its application to quantification of sulfolipids from kidneys of various mammalian species

Journal of Lipid Research, 2001
A variety of procedures have been developed for determining the sulfate ester content of various biomolecules. Ion chromatography (IC), that is, quantitation of ionic substances by ion conductimetry after separation by anion-exchange chromatography, has ...
Keiko Tadano-Aritomi, Toshiyuki Hikita, Atsushi Suzuki, Hidenao Toyoda, Toshihiko Toida, Toshio Imanari, Ineo Ishizuka   +6 more
doaj   +1 more source

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl‐Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies

Angewandte Chemie, EarlyView.
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster, Òscar Vidal‐Gironès, Rowan de Graaf, Ken Kok, Lindsey T. Lelieveld, Jackelien Hoogervorst, Maria J. Ferraz, José Pablo Rivas‐Fernández, Rob F. Lammers, Herman S. Overkleeft, Johannes M. F. G. Aerts, Rolf G. Boot, Carme Rovira, Marta Artola   +13 more
wiley   +2 more sources

The History of Carbohydrates in Type I Allergy

Frontiers in Immunology, 2020
Although first described decades ago, the relevance of carbohydrate specific antibodies as mediators of type I allergy had not been recognized until recently.
Miriam Hils, Florian Wölbing, Christiane Hilger, Jörg Fischer, Nils Hoffard, Tilo Biedermann, Tilo Biedermann   +6 more
doaj   +1 more source