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Effects of altered glycolysis levels on CD8+ T cell activation and function
Cell Death and Disease, 2023 CD8+ T cells are an important component of the body’s adaptive immune response. During viral or intracellular bacterial infections, CD8+ T cells are rapidly activated and differentiated to exert their immune function by producing cytokines.
Jiaying Cao +5 more
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Frontiers in Pharmacology, 2022 It is well known that tumor cells rely mainly on aerobic glycolysis for energy production even in the presence of oxygen, and glycolysis is a known modulator of tumorigenesis and tumor development.
Daoying Zhou +8 more
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Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation
Annual Review of Cell and Developmental Biology, 2011 Warburg's observation that cancer cells exhibit a high rate of glycolysis even in the presence of oxygen (aerobic glycolysis) sparked debate over the role of glycolysis in normal and cancer cells.
Sophia Y Lunt, Matthew G Vander Heiden
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The roles of glycolysis in osteosarcoma
Frontiers in Pharmacology, 2022 Metabolic reprogramming is of great significance in the progression of various cancers and is critical for cancer progression, diagnosis, and treatment.
Zuxi Feng, Yanghuan Ou, Liang Hao
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HIF-1α regulated GLUT1-mediated glycolysis enhances Treponema pallidum-induced cytokine responses [PDF]
Cell Communication and SignalingSyphilis, caused by Treponema pallidum (Tp), represents a significant public health challenge. The clinical manifestations of syphilis are attributed to local inflammatory responses induced by Tp, notably monocyte infiltration into local lesions and the ...
Shun Xiong +8 more
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Role of glycolysis in retinal vascular endothelium, glia, pigment epithelium, and photoreceptor cells and as therapeutic targets for related retinal diseases [PDF]
International Journal of Ophthalmology, 2021 Glycolysis produces large amounts of adenosine triphosphate (ATP) in a short time. The retinal vascular endothelium feeds itself primarily through aerobic glycolysis with less ATP.
Ting-Ting Yang, Hui Li, Li-Jie Dong
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A prediction model identifying glycolysis signature as therapeutic target for psoriasis
Frontiers in Immunology, 2023 BackgroundThe hyperproliferation featured with upregulated glycolysis is a hallmark of psoriasis. However, molecular difference of keratinocyte glycolysis amongst varied pathologic states in psoriasis remain elusive.ObjectivesTo characterize glycolysis ...
Yanhong Shou +3 more
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Modulating Glycolysis to Improve Cancer Therapy
International Journal of Molecular Sciences, 2023 Cancer cells undergo metabolic reprogramming and switch to a ‘glycolysis-dominant’ metabolic profile to promote their survival and meet their requirements for energy and macromolecules.
C. Chelakkot +3 more
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Frontiers in Immunology, 2022 Alzheimer’s disease (AD) is a common neurodegenerative disorder without an effective treatment, and results in an increasingly serious health problem. However, its pathogenesis is complex and poorly understood.
Zhiqiang Qiu +8 more
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