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Effects of altered glycolysis levels on CD8+ T cell activation and function
Cell Death and Disease, 2023 CD8+ T cells are an important component of the body’s adaptive immune response. During viral or intracellular bacterial infections, CD8+ T cells are rapidly activated and differentiated to exert their immune function by producing cytokines.
Jiaying Cao +5 more
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HIF-1α regulated GLUT1-mediated glycolysis enhances Treponema pallidum-induced cytokine responses. [PDF]
Cell Commun SignalSyphilis, caused by Treponema pallidum (Tp), represents a significant public health challenge. The clinical manifestations of syphilis are attributed to local inflammatory responses induced by Tp, notably monocyte infiltration into local lesions and the ...
Xiong S +8 more
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Warburg effect and lactylation in cancer: mechanisms for chemoresistance. [PDF]
Mol MedIn the clinical management of cancers, the emergence of chemoresistance represents a profound and imperative “pain point” that requires immediate attention. Understanding the mechanisms of chemoresistance is essential for developing effective therapeutic
Zhang W +6 more
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Role of glycolysis in retinal vascular endothelium, glia, pigment epithelium, and photoreceptor cells and as therapeutic targets for related retinal diseases [PDF]
International Journal of Ophthalmology, 2021 Glycolysis produces large amounts of adenosine triphosphate (ATP) in a short time. The retinal vascular endothelium feeds itself primarily through aerobic glycolysis with less ATP.
Ting-Ting Yang, Hui Li, Li-Jie Dong
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A prediction model identifying glycolysis signature as therapeutic target for psoriasis
Frontiers in Immunology, 2023 BackgroundThe hyperproliferation featured with upregulated glycolysis is a hallmark of psoriasis. However, molecular difference of keratinocyte glycolysis amongst varied pathologic states in psoriasis remain elusive.ObjectivesTo characterize glycolysis ...
Yanhong Shou +3 more
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Frontiers in Immunology, 2022 Alzheimer’s disease (AD) is a common neurodegenerative disorder without an effective treatment, and results in an increasingly serious health problem. However, its pathogenesis is complex and poorly understood.
Zhiqiang Qiu +8 more
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Natural products targeting glycolysis in cancer
Frontiers in Pharmacology, 2022 Many energy metabolism pathways exist in cancer, including glycolysis, amino acid metabolism, fatty acid oxidation, and mitochondrial respiration. Tumor cells mainly generate energy through glycolysis to maintain growth and biosynthesis of tumor cells ...
Yuanyuan Zhao +5 more
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Thoracic Cancer, 2021 Background Activation of ALK leads to a high level of aerobic glycolysis related to crizotinib insensitivity in anaplastic lymphoma kinase‐positive non‐small cell lung cancer (ALK+ NSCLC).
Caiyu Lin +7 more
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On the Role of Glycolysis in Early Tumorigenesis—Permissive and Executioner Effects
Cells, 2023 Reprogramming energy production from mitochondrial respiration to glycolysis is now considered a hallmark of cancer. When tumors grow beyond a certain size they give rise to changes in their microenvironment (e.g., hypoxia, mechanical stress) that are ...
Fabrizio Marcucci, Cristiano Rumio
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Integrated analysis reveals critical glycolytic regulators in hepatocellular carcinoma
Cell Communication and Signaling, 2020 Background Cancer cells primarily utilize aerobic glycolysis for energy production, a phenomenon known as the Warburg effect. Increased aerobic glycolysis supports cancer cell survival and rapid proliferation and predicts a poor prognosis in cancer ...
Chenying Lu +14 more
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