Results 1 to 10 of about 367,476 (333)

Role of glycolysis in retinal vascular endothelium, glia, pigment epithelium, and photoreceptor cells and as therapeutic targets for related retinal diseases [PDF]

International Journal of Ophthalmology, 2021
Glycolysis produces large amounts of adenosine triphosphate (ATP) in a short time. The retinal vascular endothelium feeds itself primarily through aerobic glycolysis with less ATP.
Ting-Ting Yang, Hui Li, Li-Jie Dong
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A prediction model identifying glycolysis signature as therapeutic target for psoriasis

Frontiers in Immunology, 2023
BackgroundThe hyperproliferation featured with upregulated glycolysis is a hallmark of psoriasis. However, molecular difference of keratinocyte glycolysis amongst varied pathologic states in psoriasis remain elusive.ObjectivesTo characterize glycolysis ...
Yanhong Shou, Ronghui Zhu, Zhenwei Tang, Xiao-Yong Man   +3 more
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The significance of glycolysis index and its correlations with immune infiltrates in Alzheimer’s disease

Frontiers in Immunology, 2022
Alzheimer’s disease (AD) is a common neurodegenerative disorder without an effective treatment, and results in an increasingly serious health problem. However, its pathogenesis is complex and poorly understood.
Zhiqiang Qiu, Xuanyang Bai, Xiangwen Ji, Xiang Wang, Xinye Han, Duo Wang, Fenjun Jiang, Fenjun Jiang, Yihua An   +8 more
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Effects of altered glycolysis levels on CD8+ T cell activation and function

Cell Death and Disease, 2023
CD8+ T cells are an important component of the body’s adaptive immune response. During viral or intracellular bacterial infections, CD8+ T cells are rapidly activated and differentiated to exert their immune function by producing cytokines.
Jiaying Cao, Shan Liao, Feng Zeng, Qianjin Liao, Gengqiu Luo, Yanhong Zhou   +5 more
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Natural products targeting glycolysis in cancer

Frontiers in Pharmacology, 2022
Many energy metabolism pathways exist in cancer, including glycolysis, amino acid metabolism, fatty acid oxidation, and mitochondrial respiration. Tumor cells mainly generate energy through glycolysis to maintain growth and biosynthesis of tumor cells ...
Yuanyuan Zhao, Louisa S Chard Dunmall, Zhenguo Cheng, Yaohe Wang, Yaohe Wang, Lingling Si   +5 more
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On the Role of Glycolysis in Early Tumorigenesis—Permissive and Executioner Effects

Cells, 2023
Reprogramming energy production from mitochondrial respiration to glycolysis is now considered a hallmark of cancer. When tumors grow beyond a certain size they give rise to changes in their microenvironment (e.g., hypoxia, mechanical stress) that are ...
Fabrizio Marcucci, Cristiano Rumio
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Integrated analysis reveals critical glycolytic regulators in hepatocellular carcinoma

Cell Communication and Signaling, 2020
Background Cancer cells primarily utilize aerobic glycolysis for energy production, a phenomenon known as the Warburg effect. Increased aerobic glycolysis supports cancer cell survival and rapid proliferation and predicts a poor prognosis in cancer ...
Chenying Lu, Shiji Fang, Qiaoyou Weng, Xiuling Lv, Miaomiao Meng, Jinyu Zhu, Liyun Zheng, Yumin Hu, Yang Gao, Xulu Wu, Jianting Mao, Bufu Tang, Zhongwei Zhao, Li Huang, Jiansong Ji   +14 more
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Glycolysis-associated lncRNAs identify a subgroup of cancer patients with poor prognoses and a high-infiltration immune microenvironment

BMC Medicine, 2021
Background Long noncoding (lnc)RNAs and glycolysis are both recognized as key regulators of cancers. Some lncRNAs are also reportedly involved in regulating glycolysis metabolism.
Kuo-Hao Ho, Tzu-Wen Huang, Chwen-Ming Shih, Yi-Ting Lee, Ann-Jeng Liu, Peng-Hsu Chen, Ku-Chung Chen   +6 more
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The significance of glycolysis in tumor progression and its relationship with the tumor microenvironment

Frontiers in Pharmacology, 2022
It is well known that tumor cells rely mainly on aerobic glycolysis for energy production even in the presence of oxygen, and glycolysis is a known modulator of tumorigenesis and tumor development.
Daoying Zhou, Daoying Zhou, Zhen Duan, Zhenyu Li, Zhenyu Li, Fangfang Ge, Fangfang Ge, Ran Wei, Lingsuo Kong   +8 more
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Hexokinases II‐mediated glycolysis governs susceptibility to crizotinib in ALK‐positive non‐small cell lung cancer

Thoracic Cancer, 2021
Background Activation of ALK leads to a high level of aerobic glycolysis related to crizotinib insensitivity in anaplastic lymphoma kinase‐positive non‐small cell lung cancer (ALK+ NSCLC).
Caiyu Lin, Hengyi Chen, Rui Han, Li Li, Conghua Lu, Shuai Hao, Yubo Wang, Yong He   +7 more
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