Results 11 to 20 of about 410,867 (397)
International Journal on Biological Sciences, 2023 The triggering receptor expressed on myeloid cells-1 (TREM-1) is a pro-inflammatory immune receptor potentiating acute lung injury (ALI). However, the mechanism of TREM-1-triggered inflammation response remains poorly understood.
W. Zhong +10 more
semanticscholar +1 more source
Natural products targeting glycolysis in cancer
Frontiers in Pharmacology, 2022 Many energy metabolism pathways exist in cancer, including glycolysis, amino acid metabolism, fatty acid oxidation, and mitochondrial respiration. Tumor cells mainly generate energy through glycolysis to maintain growth and biosynthesis of tumor cells ...
Yuanyuan Zhao +5 more
doaj +1 more source
m6A-regulated tumor glycolysis: new advances in epigenetics and metabolism
Molecular Cancer, 2023 Glycolytic reprogramming is one of the most important features of cancer and plays an integral role in the progression of cancer. In cancer cells, changes in glucose metabolism meet the needs of self-proliferation, angiogenesis and lymphangiogenesis ...
Shiwei Yue +6 more
semanticscholar +1 more source
Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy
Cell Metabolism, 2018 Tina Cascone +2 more
exaly +2 more sources
CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumors
Nature, 2021 Limiting metabolic competition in the tumour microenvironment may increase the effectiveness of immunotherapy. Owing to its crucial role in the glucose metabolism of activated T cells, CD28 signalling has been proposed as a metabolic biosensor of T ...
R. Zappasodi +23 more
semanticscholar +1 more source
Serine biosynthesis with one carbon catabolism represents a novel pathway for ATP generation in cells using alternative glycolysis with zero net ATP production [PDF]
, 2011 Recent experimental evidence indicates that some cancer cells have an alternative glycolysis pathway with net zero ATP production, implying that upregulation of glycolysis in these cells may not be related to the generation of ATP.
Alexei Vazquez +2 more
core +5 more sources
Thoracic Cancer, 2021 Background Activation of ALK leads to a high level of aerobic glycolysis related to crizotinib insensitivity in anaplastic lymphoma kinase‐positive non‐small cell lung cancer (ALK+ NSCLC).
Caiyu Lin +7 more
doaj +1 more source
On the Role of Glycolysis in Early Tumorigenesis—Permissive and Executioner Effects
Cells, 2023 Reprogramming energy production from mitochondrial respiration to glycolysis is now considered a hallmark of cancer. When tumors grow beyond a certain size they give rise to changes in their microenvironment (e.g., hypoxia, mechanical stress) that are ...
Fabrizio Marcucci, Cristiano Rumio
doaj +1 more source