Results 11 to 20 of about 265,367 (335)

The significance of glycolysis in tumor progression and its relationship with the tumor microenvironment

Frontiers in Pharmacology, 2022
It is well known that tumor cells rely mainly on aerobic glycolysis for energy production even in the presence of oxygen, and glycolysis is a known modulator of tumorigenesis and tumor development.
Daoying Zhou, Daoying Zhou, Zhen Duan, Zhenyu Li, Zhenyu Li, Fangfang Ge, Fangfang Ge, Ran Wei, Lingsuo Kong   +8 more
doaj   +2 more sources

Modulating Glycolysis to Improve Cancer Therapy

International Journal of Molecular Sciences, 2023
Cancer cells undergo metabolic reprogramming and switch to a ‘glycolysis-dominant’ metabolic profile to promote their survival and meet their requirements for energy and macromolecules.
C. Chelakkot, Vipin Shankar Chelakkot, Y. Shin, Kyoung Song   +3 more
semanticscholar   +1 more source

TREM-1 governs NLRP3 inflammasome activation of macrophages by firing up glycolysis in acute lung injury

International Journal on Biological Sciences, 2023
The triggering receptor expressed on myeloid cells-1 (TREM-1) is a pro-inflammatory immune receptor potentiating acute lung injury (ALI). However, the mechanism of TREM-1-triggered inflammation response remains poorly understood.
W. Zhong, Tian Liu, Hui-Hui Yang, J. Duan, Jin-Tong Yang, Xin‐Xin Guan, Jian-Bing Xiong, Yan-Feng Zhang, Chen-Yu Zhang, Yong Zhou, C. Guan   +10 more
semanticscholar   +1 more source

CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumors

Nature, 2021
Limiting metabolic competition in the tumour microenvironment may increase the effectiveness of immunotherapy. Owing to its crucial role in the glucose metabolism of activated T cells, CD28 signalling has been proposed as a metabolic biosensor of T ...
R. Zappasodi, I. Serganova, Ivan J. Cohen, Masatomo Maeda, M. Shindo, Y. Şenbabaoğlu, M. Watson, A. Leftin, R. Maniyar, Svena Verma, M. Lubin, M. Ko, Mayuresh Mane, H. Zhong, Cailian Liu, Arnab Ghosh, Mohsen Abu-Akeel, E. Ackerstaff, J. Koutcher, Ping-Chih Ho, Greg M. Delgoffe, R. Blasberg, J. Wolchok, T. Merghoub   +23 more
semanticscholar   +1 more source

Natural products target glycolysis in liver disease

Frontiers in Pharmacology, 2023
Mitochondrial dysfunction plays an important role in the occurrence and development of different liver diseases. Oxidative phosphorylation (OXPHOS) dysfunction and production of reactive oxygen species are closely related to mitochondrial dysfunction ...
Shenghao Li, Shenghao Li, Liyuan Hao, Liyuan Hao, Xiaoyu Hu   +4 more
doaj   +1 more source

Glycolysis-associated lncRNAs identify a subgroup of cancer patients with poor prognoses and a high-infiltration immune microenvironment

BMC Medicine, 2021
Background Long noncoding (lnc)RNAs and glycolysis are both recognized as key regulators of cancers. Some lncRNAs are also reportedly involved in regulating glycolysis metabolism.
Kuo-Hao Ho, Tzu-Wen Huang, Chwen-Ming Shih, Yi-Ting Lee, Ann-Jeng Liu, Peng-Hsu Chen, Ku-Chung Chen   +6 more
doaj   +1 more source

FTO suppresses glycolysis and growth of papillary thyroid cancer via decreasing stability of APOE mRNA in an N6-methyladenosine-dependent manner

Journal of experimental & clinical cancer research : CR, 2022
Background N6-methyladenosine (m 6 A) modification is the most common chemical modification in mammalian mRNAs, and it plays important roles by regulating several cellular processes.
Jiapeng Huang, Wei Sun, Zhihong Wang, Chengzhou Lv, Ting Zhang, Dalin Zhang, W. Dong, Liang Shao, Liang He, Xiaoyue Ji, Ping Zhang, Hao Zhang   +11 more
semanticscholar   +1 more source

Exosome‐delivered circRNA promotes glycolysis to induce chemoresistance through the miR‐122‐PKM2 axis in colorectal cancer

Molecular Oncology, 2020
Malignant tumors, including colorectal cancer (CRC), usually rely on ATP generation through aerobic glycolysis for both rapid growth and chemotherapy resistance.
Xinyi Wang, Haiyang Zhang, Haiou Yang, M. Bai, T. Ning, T. Deng, Rui Liu, Q. Fan, Kegan Zhu, Jialu Li, Yang Zhan, G. Ying, Y. Ba   +12 more
semanticscholar   +1 more source

Immune effects of PI3K/Akt/HIF-1α-regulated glycolysis in polymorphonuclear neutrophils during sepsis

Critical Care, 2022
Background Effective removal of pathogenic bacteria is key to improving the prognosis of sepsis. Polymorphonuclear neutrophils (PMNs) are the most important components of innate cellular immunity and play vital roles in clearing pathogenic bacteria ...
T. Pan, Shaoqiong Sun, Yang Chen, R. Tian, E. Chen, R. Tan, Xiaoli Wang, Zhaojun Liu, Jialin Liu, H. Qu   +9 more
semanticscholar   +1 more source

SIPA1 Enhances Aerobic Glycolysis Through HIF-2α Pathway to Promote Breast Cancer Metastasis

Frontiers in Cell and Developmental Biology, 2022
Increased dependence on aerobic glycolysis is characteristic of most cancer cells, whereas the mechanism underlying the promotion of aerobic glycolysis in metastatic breast cancer cells under ambient oxygen has not been well understood.
Chenguang Yao, Jun Weng, Lingyun Feng, Wanjun Zhang, Yan Xu, Peijing Zhang, Yoshimasa Tanaka, Li Su   +7 more
doaj   +1 more source