Results 11 to 20 of about 226,351 (284)
Frontiers in Pharmacology, 2022 It is well known that tumor cells rely mainly on aerobic glycolysis for energy production even in the presence of oxygen, and glycolysis is a known modulator of tumorigenesis and tumor development.
Daoying Zhou +8 more
doaj +1 more source
Neurons require glucose uptake and glycolysis in vivo
Cell Reports, 2023 Summary: Neurons require large amounts of energy, but whether they can perform glycolysis or require glycolysis to maintain energy remains unclear. Using metabolomics, we show that human neurons do metabolize glucose through glycolysis and can rely on ...
Huihui Li +18 more
doaj +1 more source
SIPA1 Enhances Aerobic Glycolysis Through HIF-2α Pathway to Promote Breast Cancer Metastasis
Frontiers in Cell and Developmental Biology, 2022 Increased dependence on aerobic glycolysis is characteristic of most cancer cells, whereas the mechanism underlying the promotion of aerobic glycolysis in metastatic breast cancer cells under ambient oxygen has not been well understood.
Chenguang Yao +7 more
doaj +1 more source
Natural products target glycolysis in liver disease
Frontiers in Pharmacology, 2023 Mitochondrial dysfunction plays an important role in the occurrence and development of different liver diseases. Oxidative phosphorylation (OXPHOS) dysfunction and production of reactive oxygen species are closely related to mitochondrial dysfunction ...
Shenghao Li +4 more
doaj +1 more source
Frontiers in Microbiology, 2023 IntroductionMicrobiome plays roles in lung adenocarcinoma (LUAD) development and anti-tumor treatment efficacy. Aberrant glycolysis in tumor might promote lactate production that alter tumor microenvironment, affecting microbiome, cancer cells and immune
Xiaheng Deng +4 more
doaj +1 more source
Diabetologia, 1993 Glycolysis is usually considered as a paradigm metabolic pathway, due to the fact that it is present in most organisms, and also because it is the pathway by which an important nutrient, glucose, is consumed. Far from being completely understood, the regulation of this pathway witnessed several important progresses during the last few years.
openaire +2 more sources
Glycolysis in the control of blood glucose homeostasis
Acta Pharmaceutica Sinica B, 2012 Glycolysis, a simple pathway of glucose metabolism, critically regulates insulin secretion and metabolic functions of various cells. Depending on cell types, rates of glycolysis are determined at various steps of glycolysis that are subjected to the ...
Xin Guo +7 more
doaj +1 more source
Serine biosynthesis with one carbon catabolism and the glycine cleavage system represents a novel pathway for ATP generation. [PDF]
PLoS ONE, 2011 Previous experimental evidence indicates that some cancer cells have an alternative glycolysis pathway with net zero ATP production, implying that upregulation of glycolysis in these cells may not be related to the generation of ATP. Here we use a genome-
Alexei Vazquez +2 more
doaj +1 more source
Glycolysis drives STING signaling to facilitate dendritic cell antitumor function
The Journal of Clinical Investigation, 2023 Activation of STING signaling in DCs promotes antitumor immunity. Aerobic glycolysis is a metabolic hallmark of activated DCs, but how the glycolytic pathway intersects with STING signaling in tumor-infiltrating DCs remains elusive.
Zhilin Hu +11 more
doaj +1 more source
The Mechanism of Warburg Effect-Induced Chemoresistance in Cancer
Frontiers in Oncology, 2021 Although chemotherapy can improve the overall survival and prognosis of cancer patients, chemoresistance remains an obstacle due to the diversity, heterogeneity, and adaptability to environmental alters in clinic.
Chang Liu, Ying Jin, Zhimin Fan
doaj +1 more source