Results 21 to 30 of about 260,676 (239)

Glycolysis-associated lncRNAs identify a subgroup of cancer patients with poor prognoses and a high-infiltration immune microenvironment

BMC Medicine, 2021
Background Long noncoding (lnc)RNAs and glycolysis are both recognized as key regulators of cancers. Some lncRNAs are also reportedly involved in regulating glycolysis metabolism.
Kuo-Hao Ho, Tzu-Wen Huang, Chwen-Ming Shih, Yi-Ting Lee, Ann-Jeng Liu, Peng-Hsu Chen, Ku-Chung Chen   +6 more
doaj   +1 more source

Integrated analysis reveals critical glycolytic regulators in hepatocellular carcinoma

Cell Communication and Signaling, 2020
Background Cancer cells primarily utilize aerobic glycolysis for energy production, a phenomenon known as the Warburg effect. Increased aerobic glycolysis supports cancer cell survival and rapid proliferation and predicts a poor prognosis in cancer ...
Chenying Lu, Shiji Fang, Qiaoyou Weng, Xiuling Lv, Miaomiao Meng, Jinyu Zhu, Liyun Zheng, Yumin Hu, Yang Gao, Xulu Wu, Jianting Mao, Bufu Tang, Zhongwei Zhao, Li Huang, Jiansong Ji   +14 more
doaj   +1 more source

Natural products target glycolysis in liver disease

Frontiers in Pharmacology, 2023
Mitochondrial dysfunction plays an important role in the occurrence and development of different liver diseases. Oxidative phosphorylation (OXPHOS) dysfunction and production of reactive oxygen species are closely related to mitochondrial dysfunction ...
Shenghao Li, Shenghao Li, Liyuan Hao, Liyuan Hao, Xiaoyu Hu   +4 more
doaj   +1 more source

CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumors

Nature, 2021
Limiting metabolic competition in the tumour microenvironment may increase the effectiveness of immunotherapy. Owing to its crucial role in the glucose metabolism of activated T cells, CD28 signalling has been proposed as a metabolic biosensor of T ...
R. Zappasodi, I. Serganova, Ivan J. Cohen, Masatomo Maeda, M. Shindo, Y. Şenbabaoğlu, M. Watson, A. Leftin, R. Maniyar, Svena Verma, M. Lubin, M. Ko, Mayuresh Mane, H. Zhong, Cailian Liu, Arnab Ghosh, Mohsen Abu-Akeel, E. Ackerstaff, J. Koutcher, Ping-Chih Ho, Greg M. Delgoffe, R. Blasberg, J. Wolchok, T. Merghoub   +23 more
semanticscholar   +1 more source

Exosome‐delivered circRNA promotes glycolysis to induce chemoresistance through the miR‐122‐PKM2 axis in colorectal cancer

Molecular Oncology, 2020
Malignant tumors, including colorectal cancer (CRC), usually rely on ATP generation through aerobic glycolysis for both rapid growth and chemotherapy resistance.
Xinyi Wang, Haiyang Zhang, Haiou Yang, M. Bai, T. Ning, T. Deng, Rui Liu, Q. Fan, Kegan Zhu, Jialu Li, Yang Zhan, G. Ying, Y. Ba   +12 more
semanticscholar   +1 more source

Regulation of glycolysis by the hypoxia‐inducible factor (HIF): implications for cellular physiology

Journal of Physiology, 2020
Under conditions of hypoxia, most eukaryotic cells can shift their primary metabolic strategy from predominantly mitochondrial respiration towards increased glycolysis to maintain ATP levels.
S. Kierans, C. Taylor
semanticscholar   +1 more source

FTO suppresses glycolysis and growth of papillary thyroid cancer via decreasing stability of APOE mRNA in an N6-methyladenosine-dependent manner

Journal of experimental & clinical cancer research : CR, 2022
Background N6-methyladenosine (m 6 A) modification is the most common chemical modification in mammalian mRNAs, and it plays important roles by regulating several cellular processes.
Jiapeng Huang, Wei Sun, Zhihong Wang, Chengzhou Lv, Ting Zhang, Dalin Zhang, W. Dong, Liang Shao, Liang He, Xiaoyue Ji, Ping Zhang, Hao Zhang   +11 more
semanticscholar   +1 more source

Emerging roles and the regulation of aerobic glycolysis in hepatocellular carcinoma

Journal of experimental & clinical cancer research : CR, 2020
Liver cancer has become the sixth most diagnosed cancer and the fourth leading cause of cancer death worldwide. Hepatocellular carcinoma (HCC) is responsible for up to 75–85% of primary liver cancers, and sorafenib is the first targeted drug for advanced
Jiao Feng, Jingjing Li, Liwei Wu, Qiang Yu, J. Ji, Jianye Wu, Wei-qi Dai, Chuanyong Guo   +7 more
semanticscholar   +1 more source

Immune effects of PI3K/Akt/HIF-1α-regulated glycolysis in polymorphonuclear neutrophils during sepsis

Critical Care, 2022
Background Effective removal of pathogenic bacteria is key to improving the prognosis of sepsis. Polymorphonuclear neutrophils (PMNs) are the most important components of innate cellular immunity and play vital roles in clearing pathogenic bacteria ...
T. Pan, Shaoqiong Sun, Yang Chen, R. Tian, E. Chen, R. Tan, Xiaoli Wang, Zhaojun Liu, Jialin Liu, H. Qu   +9 more
semanticscholar   +1 more source

Glycolysis – a key player in the inflammatory response

The FEBS Journal, 2020
The inflammatory response involves the activation of several cell types to fight insults caused by a plethora of agents, and to maintain the tissue homoeostasis.
G. Soto-Heredero, M. M. Gómez de las Heras, E. Gabandé-Rodríguez, J. Oller, M. Mittelbrunn   +4 more
semanticscholar   +1 more source