Results 21 to 30 of about 358,226 (336)

Natural products targeting glycolysis in cancer

Frontiers in Pharmacology, 2022
Many energy metabolism pathways exist in cancer, including glycolysis, amino acid metabolism, fatty acid oxidation, and mitochondrial respiration. Tumor cells mainly generate energy through glycolysis to maintain growth and biosynthesis of tumor cells ...
Yuanyuan Zhao, Louisa S Chard Dunmall, Zhenguo Cheng, Yaohe Wang, Yaohe Wang, Lingling Si   +5 more
doaj   +1 more source

Serine biosynthesis with one carbon catabolism represents a novel pathway for ATP generation in cells using alternative glycolysis with zero net ATP production [PDF]

, 2011
Recent experimental evidence indicates that some cancer cells have an alternative glycolysis pathway with net zero ATP production, implying that upregulation of glycolysis in these cells may not be related to the generation of ATP.
Alexei Vazquez, Elke K. Markert, Zoltan N. Oltvai   +2 more
core   +5 more sources

On the Role of Glycolysis in Early Tumorigenesis—Permissive and Executioner Effects

Cells, 2023
Reprogramming energy production from mitochondrial respiration to glycolysis is now considered a hallmark of cancer. When tumors grow beyond a certain size they give rise to changes in their microenvironment (e.g., hypoxia, mechanical stress) that are ...
Fabrizio Marcucci, Cristiano Rumio
doaj   +1 more source

Glycolysis-associated lncRNAs identify a subgroup of cancer patients with poor prognoses and a high-infiltration immune microenvironment

BMC Medicine, 2021
Background Long noncoding (lnc)RNAs and glycolysis are both recognized as key regulators of cancers. Some lncRNAs are also reportedly involved in regulating glycolysis metabolism.
Kuo-Hao Ho, Tzu-Wen Huang, Chwen-Ming Shih, Yi-Ting Lee, Ann-Jeng Liu, Peng-Hsu Chen, Ku-Chung Chen   +6 more
doaj   +1 more source

Integrated analysis reveals critical glycolytic regulators in hepatocellular carcinoma

Cell Communication and Signaling, 2020
Background Cancer cells primarily utilize aerobic glycolysis for energy production, a phenomenon known as the Warburg effect. Increased aerobic glycolysis supports cancer cell survival and rapid proliferation and predicts a poor prognosis in cancer ...
Chenying Lu, Shiji Fang, Qiaoyou Weng, Xiuling Lv, Miaomiao Meng, Jinyu Zhu, Liyun Zheng, Yumin Hu, Yang Gao, Xulu Wu, Jianting Mao, Bufu Tang, Zhongwei Zhao, Li Huang, Jiansong Ji   +14 more
doaj   +1 more source

Hexokinases II‐mediated glycolysis governs susceptibility to crizotinib in ALK‐positive non‐small cell lung cancer

Thoracic Cancer, 2021
Background Activation of ALK leads to a high level of aerobic glycolysis related to crizotinib insensitivity in anaplastic lymphoma kinase‐positive non‐small cell lung cancer (ALK+ NSCLC).
Caiyu Lin, Hengyi Chen, Rui Han, Li Li, Conghua Lu, Shuai Hao, Yubo Wang, Yong He   +7 more
doaj   +1 more source

The significance of glycolysis in tumor progression and its relationship with the tumor microenvironment

Frontiers in Pharmacology, 2022
It is well known that tumor cells rely mainly on aerobic glycolysis for energy production even in the presence of oxygen, and glycolysis is a known modulator of tumorigenesis and tumor development.
Daoying Zhou, Daoying Zhou, Zhen Duan, Zhenyu Li, Zhenyu Li, Fangfang Ge, Fangfang Ge, Ran Wei, Lingsuo Kong   +8 more
doaj   +1 more source

Neurons require glucose uptake and glycolysis in vivo

Cell Reports, 2023
Summary: Neurons require large amounts of energy, but whether they can perform glycolysis or require glycolysis to maintain energy remains unclear. Using metabolomics, we show that human neurons do metabolize glucose through glycolysis and can rely on ...
Huihui Li, Caroline Guglielmetti, Yoshitaka J. Sei, Misha Zilberter, Lydia M. Le Page, Lauren Shields, Joyce Yang, Kevin Nguyen, Brice Tiret, Xiao Gao, Neal Bennett, Iris Lo, Talya L. Dayton, Martin Kampmann, Yadong Huang, Jeffrey C. Rathmell, Matthew Vander Heiden, Myriam M. Chaumeil, Ken Nakamura   +18 more
doaj   +1 more source

SIPA1 Enhances Aerobic Glycolysis Through HIF-2α Pathway to Promote Breast Cancer Metastasis

Frontiers in Cell and Developmental Biology, 2022
Increased dependence on aerobic glycolysis is characteristic of most cancer cells, whereas the mechanism underlying the promotion of aerobic glycolysis in metastatic breast cancer cells under ambient oxygen has not been well understood.
Chenguang Yao, Jun Weng, Lingyun Feng, Wanjun Zhang, Yan Xu, Peijing Zhang, Yoshimasa Tanaka, Li Su   +7 more
doaj   +1 more source

Natural products target glycolysis in liver disease

Frontiers in Pharmacology, 2023
Mitochondrial dysfunction plays an important role in the occurrence and development of different liver diseases. Oxidative phosphorylation (OXPHOS) dysfunction and production of reactive oxygen species are closely related to mitochondrial dysfunction ...
Shenghao Li, Shenghao Li, Liyuan Hao, Liyuan Hao, Xiaoyu Hu   +4 more
doaj   +1 more source