Results 41 to 50 of about 260,676 (239)

The Mechanism of Warburg Effect-Induced Chemoresistance in Cancer

Frontiers in Oncology, 2021
Although chemotherapy can improve the overall survival and prognosis of cancer patients, chemoresistance remains an obstacle due to the diversity, heterogeneity, and adaptability to environmental alters in clinic.
Chang Liu, Ying Jin, Zhimin Fan
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Cancer-Secreted Exosomal MiR-620 Inhibits ESCC Aerobic Glycolysis via FOXM1/HER2 Pathway and Promotes Metastasis

Frontiers in Oncology, 2022
BackgroundEsophageal squamous cell carcinoma (ESCC) is a leading cause of cancer death worldwide. MicroRNAs (MiRNAs) have been reported to regulate cell functions through exosomes.
Yanbo Zhu, Fang Li, Yilong Wan, Yilong Wan, Hansi Liang, Si Li, Bo Peng, Bo Peng, Liqun Shao, Liqun Shao, Yunyun Xu, Dong Jiang, Dong Jiang   +12 more
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A glycolysis-related two-gene risk model that can effectively predict the prognosis of patients with rectal cancer

Human Genomics, 2022
Background Aerobic glycolysis is an emerging hallmark of cancer. Although some studies have constructed glycolysis-related prognostic models of colon adenocarcinoma (COAD) based on The Cancer Genome Atlas (TCGA) database, whether the COAD glycolysis ...
Zhenzhen Liu, Zhentao Liu, Xin Zhou, Yongqu Lu, Yanhong Yao, Wendong Wang, Siyi Lu, Bingyan Wang, Fei Li, Wei Fu   +9 more
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A reciprocal feedback between N6-methyladenosine reader YTHDF3 and lncRNA DICER1-AS1 promotes glycolysis of pancreatic cancer through inhibiting maturation of miR-5586-5p

Journal of experimental & clinical cancer research : CR, 2022
Background Glycolysis is a pivotal process in metabolic reprogramming of tumorigenesis. Previous research has indicated that lncRNAs might play crucial roles in glycolysis of various tumors.
Yuhang Hu, Jiang Tang, Feng-yu Xu, Jin-huang Chen, Zhu Zeng, Shengbo Han, Fan Wang, Decai Wang, Mengqi Huang, Yong Zhao, Yan Huang, Wen-feng Zhuo, Gang Zhao   +12 more
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PKM2 coordinates glycolysis with mitochondrial fusion and oxidative phosphorylation

Protein & Cell, 2019
A change in the metabolic flux of glucose from mitochondrial oxidative phosphorylation (OXPHOS) to aerobic glycolysis is regarded as one hallmark of cancer. However, the mechanisms underlying the metabolic switch between aerobic glycolysis and OXPHOS are
Tong Li, Jinbo Han, Liangjie Jia, Xiao Hu, Liqun Chen, Yiguo Wang   +5 more
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Interactions between NLRP3 inflammasome and glycolysis in macrophages: New insights into chronic inflammation pathogenesis

Immunity, Inflammation and Disease, 2022
NLRP3 inflammasome activation in macrophages fuels sterile inflammation, which has been tied with metabolic reprogramming characterized by high glycolysis and low oxidative phosphorylation.
Qun Yu, Maojuan Guo, Wenyun Zeng, Miao Zeng, Xiaolu Zhang, Yue Zhang, Wenlan Zhang, Xijuan Jiang, Bin Yu   +8 more
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The transcription factor KLF14 regulates macrophage glycolysis and immune function by inhibiting HK2 in sepsis

Cellular & Molecular Immunology, 2022
Sepsis is a heterogeneous syndrome induced by a dysregulated host response to infection. Glycolysis plays a role in maintaining the immune function of macrophages, which is crucial for severely septic patients.
Yuan Yuan, Guangjian Fan, Yuqi Liu, L. Liu, Tong Zhang, Pengfei Liu, Q. Tu, Xinyi Zhang, S. Luo, Liangfang Yao, Feng Chen, Jingbao Li   +11 more
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The roles of glycolysis in osteosarcoma

Frontiers in Pharmacology, 2022
Metabolic reprogramming is of great significance in the progression of various cancers and is critical for cancer progression, diagnosis, and treatment.
Zuxi Feng, Yanghuan Ou, Liang Hao
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Targeting glycolysis in non-small cell lung cancer: Promises and challenges

Frontiers in Pharmacology, 2022
Metabolic disturbance, particularly of glucose metabolism, is a hallmark of tumors such as non-small cell lung cancer (NSCLC). Cancer cells tend to reprogram a majority of glucose metabolism reactions into glycolysis, even in oxygen-rich environments ...
Jia-Qi Xu, Yan-Li Fu, Jing Zhang, Kai-Yu Zhang, Jie Ma, Jing-Yi Tang, Zhi-Wei Zhang, Zhong-Yan Zhou, Zhong-Yan Zhou   +8 more
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Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization.

Proceedings of the National Academy of Sciences of the United States of America, 1994
Glutamate, released at a majority of excitatory synapses in the central nervous system, depolarizes neurons by acting at specific receptors. Its action is terminated by removal from the synaptic cleft mostly via Na(+)-dependent uptake systems located on ...
L. Pellerin, P. Magistretti
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