Results 41 to 50 of about 265,367 (335)

The Mechanism of Warburg Effect-Induced Chemoresistance in Cancer

Frontiers in Oncology, 2021
Although chemotherapy can improve the overall survival and prognosis of cancer patients, chemoresistance remains an obstacle due to the diversity, heterogeneity, and adaptability to environmental alters in clinic.
Chang Liu, Ying Jin, Zhimin Fan
doaj   +1 more source

A reciprocal feedback between N6-methyladenosine reader YTHDF3 and lncRNA DICER1-AS1 promotes glycolysis of pancreatic cancer through inhibiting maturation of miR-5586-5p

Journal of experimental & clinical cancer research : CR, 2022
Background Glycolysis is a pivotal process in metabolic reprogramming of tumorigenesis. Previous research has indicated that lncRNAs might play crucial roles in glycolysis of various tumors.
Yuhang Hu, Jiang Tang, Feng-yu Xu, Jin-huang Chen, Zhu Zeng, Shengbo Han, Fan Wang, Decai Wang, Mengqi Huang, Yong Zhao, Yan Huang, Wen-feng Zhuo, Gang Zhao   +12 more
semanticscholar   +1 more source

Comprehensive analysis of aerobic glycolysis-related genes for prognosis, immune features and drug treatment strategy in prostate cancer

Frontiers in Oncology, 2022
BackgroundThe dysregulated expression of aerobic glycolysis-related genes is closely related to prostate cancer progression and metastasis. However, reliable prognostic signatures based on aerobic glycolysis have not been well established.MethodsWe ...
Wei He, Xiang He, Enhui Li
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mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation

Cell Reports, 2015
The mammalian target of rapamycin complex 1 (mTORC1) regulates activation of immune cells and cellular energy metabolism. Although glycolysis has been linked to immune functions, the mechanisms by which glycolysis regulates NLRP3 inflammasome activation ...
Jong-Seok Moon, Shu Hisata, Mi-Ae Park, Gina M. DeNicola, Stefan W. Ryter, Kiichi Nakahira, Augustine M.K. Choi   +6 more
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Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step

eLife, 2014
Aerobic glycolysis or the Warburg Effect (WE) is characterized by the increased metabolism of glucose to lactate. It remains unknown what quantitative changes to the activity of metabolism are necessary and sufficient for this phenotype.
Alexander A Shestov, Xiaojing Liu, Zheng Ser, Ahmad A Cluntun, Yin P Hung, Lei Huang, Dongsung Kim, Anne Le, Gary Yellen, John G Albeck, Jason W Locasale   +10 more
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Interactions between NLRP3 inflammasome and glycolysis in macrophages: New insights into chronic inflammation pathogenesis

Immunity, Inflammation and Disease, 2022
NLRP3 inflammasome activation in macrophages fuels sterile inflammation, which has been tied with metabolic reprogramming characterized by high glycolysis and low oxidative phosphorylation.
Qun Yu, Maojuan Guo, Wenyun Zeng, Miao Zeng, Xiaolu Zhang, Yue Zhang, Wenlan Zhang, Xijuan Jiang, Bin Yu   +8 more
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Coxsackievirus B3 infection induces glycolysis to facilitate viral replication

Frontiers in Microbiology, 2022
Coxsackievirus B3 (CVB3) is a leading cause of viral myocarditis, but no effective treatment strategy against CVB3 is available. Viruses lack an inherent metabolic system and thus depend on host cellular metabolism for their benefit.
Yujie Qian, Yeyi Yang, Wenxiang Qing, Chunyun Li, Min Kong, Zhijuan Kang, Yuanbojiao Zuo, Jiping Wu, Meng Yu, Zuocheng Yang   +9 more
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Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization.

Proceedings of the National Academy of Sciences of the United States of America, 1994
Glutamate, released at a majority of excitatory synapses in the central nervous system, depolarizes neurons by acting at specific receptors. Its action is terminated by removal from the synaptic cleft mostly via Na(+)-dependent uptake systems located on ...
L. Pellerin, P. Magistretti
semanticscholar   +1 more source

The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis

Nature Communications, 2021
Hypoxia-inducible factor-1 (HIF-1) is a master driver of glucose metabolism in cancer cells. Here, we demonstrate that a HIF-1α anti-sense lncRNA, HIFAL, is essential for maintaining and enhancing HIF-1α-mediated transactivation and glycolysis ...
Fang Zheng, Jianing Chen, Xiaoqian Zhang, Zifeng Wang, Jiewen Chen, Xiaorong Lin, Hongyan Huang, Wenkui Fu, Jing Liang, Wei Wu, Bo Li, H. Yao, Hai Hu, E. Song   +13 more
semanticscholar   +1 more source

The fatty acid receptor CD36 promotes HCC progression through activating Src/PI3K/AKT axis-dependent aerobic glycolysis

Cell Death and Disease, 2021
Metabolic reprogramming is a new hallmark of cancer but it remains poorly defined in hepatocellular carcinogenesis (HCC). The fatty acid receptor CD36 is associated with both lipid and glucose metabolism in the liver.
Xiaoqing Luo, Enze Zheng, Li Wei, H. Zeng, H. Qin, Xiaoyu Zhang, Meng Liao, Lin Chen, Lei Zhao, X. Ruan, Ping Yang, Yaxi Chen   +11 more
semanticscholar   +1 more source