Results 51 to 60 of about 410,867 (397)

PKM2 coordinates glycolysis with mitochondrial fusion and oxidative phosphorylation

Protein & Cell, 2019
A change in the metabolic flux of glucose from mitochondrial oxidative phosphorylation (OXPHOS) to aerobic glycolysis is regarded as one hallmark of cancer. However, the mechanisms underlying the metabolic switch between aerobic glycolysis and OXPHOS are
Tong Li, Jinbo Han, Liangjie Jia, Xiao Hu, Liqun Chen, Yiguo Wang   +5 more
doaj   +1 more source

The Mechanism of Warburg Effect-Induced Chemoresistance in Cancer

Frontiers in Oncology, 2021
Although chemotherapy can improve the overall survival and prognosis of cancer patients, chemoresistance remains an obstacle due to the diversity, heterogeneity, and adaptability to environmental alters in clinic.
Chang Liu, Ying Jin, Zhimin Fan
doaj   +1 more source

The transcription factor KLF14 regulates macrophage glycolysis and immune function by inhibiting HK2 in sepsis

Cellular & Molecular Immunology, 2022
Sepsis is a heterogeneous syndrome induced by a dysregulated host response to infection. Glycolysis plays a role in maintaining the immune function of macrophages, which is crucial for severely septic patients.
Yuan Yuan, Guangjian Fan, Yuqi Liu, L. Liu, Tong Zhang, Pengfei Liu, Q. Tu, Xinyi Zhang, S. Luo, Liangfang Yao, Feng Chen, Jingbao Li   +11 more
semanticscholar   +1 more source

Molecular crowding defines a common origin for the Warburg effect in proliferating cells and the lactate threshold in muscle physiology [PDF]

, 2011
Aerobic glycolysis is a seemingly wasteful mode of ATP production that is seen both in rapidly proliferating mammalian cells and highly active contracting muscles, but whether there is a common origin for its presence in these widely different systems is
A Vazquez, A Vazquez, A Vazquez, Alexei Vazquez, AV Hill, B Lee, D Voet, DA Hume, DG Hardie, DJ Marcinek, DR Wise, E Blomstrand, G Parra-Bonilla, H Hoppeler, J Achten, J Schellenberger, JM Savinell, JW Locasale, K Schwerzmann, K Sheikh, KE Conley, KR Short, MC Hogan, MG Vander Heiden, MJ Joyner, O Trabold, O Warburg, P Gao, PA Farrell, PR Rich, QK Beg, R Wibom, R Williams, RJ DeBerardinis, RK Scopes, T Shlomi, T Wang, U Glas, W Hu, WF Kemper, WH Munyon, XY Hou, Y Liu, Y Liu, Y Sidorenko, Yamir Moreno, Zoltán N. Oltvai   +46 more
core   +14 more sources

Comprehensive analysis of aerobic glycolysis-related genes for prognosis, immune features and drug treatment strategy in prostate cancer

Frontiers in Oncology, 2022
BackgroundThe dysregulated expression of aerobic glycolysis-related genes is closely related to prostate cancer progression and metastasis. However, reliable prognostic signatures based on aerobic glycolysis have not been well established.MethodsWe ...
Wei He, Xiang He, Enhui Li
doaj   +1 more source

A reciprocal feedback between N6-methyladenosine reader YTHDF3 and lncRNA DICER1-AS1 promotes glycolysis of pancreatic cancer through inhibiting maturation of miR-5586-5p

Journal of experimental & clinical cancer research : CR, 2022
Background Glycolysis is a pivotal process in metabolic reprogramming of tumorigenesis. Previous research has indicated that lncRNAs might play crucial roles in glycolysis of various tumors.
Yuhang Hu, Jiang Tang, Feng-yu Xu, Jin-huang Chen, Zhu Zeng, Shengbo Han, Fan Wang, Decai Wang, Mengqi Huang, Yong Zhao, Yan Huang, Wen-feng Zhuo, Gang Zhao   +12 more
semanticscholar   +1 more source

mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation

Cell Reports, 2015
The mammalian target of rapamycin complex 1 (mTORC1) regulates activation of immune cells and cellular energy metabolism. Although glycolysis has been linked to immune functions, the mechanisms by which glycolysis regulates NLRP3 inflammasome activation ...
Jong-Seok Moon, Shu Hisata, Mi-Ae Park, Gina M. DeNicola, Stefan W. Ryter, Kiichi Nakahira, Augustine M.K. Choi   +6 more
doaj   +1 more source

The paradox between resistance to hypoxia and liability to hypoxic damage in hyperglycemic peripheral nerves. Evidence for glycolysis involvement [PDF]

, 1993
Isolated ventral and dorsal rat spinal roots incubated in normal (2.5 mM) or high glucose (25 mM) concentrations or in high concentrations of other hexoses were exposed transiently to hypoxia (30 min) in a solution of low buffering power.
Grafe, Peter, Niedermeier, W., Schneider, Uwe   +2 more
core   +1 more source

Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step

eLife, 2014
Aerobic glycolysis or the Warburg Effect (WE) is characterized by the increased metabolism of glucose to lactate. It remains unknown what quantitative changes to the activity of metabolism are necessary and sufficient for this phenotype.
Alexander A Shestov, Xiaojing Liu, Zheng Ser, Ahmad A Cluntun, Yin P Hung, Lei Huang, Dongsung Kim, Anne Le, Gary Yellen, John G Albeck, Jason W Locasale   +10 more
doaj   +1 more source

Impact of limited solvent capacity on metabolic rate, enzyme activities, and metabolite concentrations of S. cerevisiae glycolysis [PDF]

, 2008
The cell's cytoplasm is crowded by its various molecular components, resulting in a limited solvent capacity for the allocation of new proteins, thus constraining various cellular processes such as metabolism.
Barabási, AL, De Menezes, MA, Oltvai, ZN, Vazquez, A   +3 more
core   +1 more source