Results 51 to 60 of about 260,676 (239)

mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation

Cell Reports, 2015
The mammalian target of rapamycin complex 1 (mTORC1) regulates activation of immune cells and cellular energy metabolism. Although glycolysis has been linked to immune functions, the mechanisms by which glycolysis regulates NLRP3 inflammasome activation ...
Jong-Seok Moon, Shu Hisata, Mi-Ae Park, Gina M. DeNicola, Stefan W. Ryter, Kiichi Nakahira, Augustine M.K. Choi   +6 more
doaj   +1 more source

Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step

eLife, 2014
Aerobic glycolysis or the Warburg Effect (WE) is characterized by the increased metabolism of glucose to lactate. It remains unknown what quantitative changes to the activity of metabolism are necessary and sufficient for this phenotype.
Alexander A Shestov, Xiaojing Liu, Zheng Ser, Ahmad A Cluntun, Yin P Hung, Lei Huang, Dongsung Kim, Anne Le, Gary Yellen, John G Albeck, Jason W Locasale   +10 more
doaj   +1 more source

Comprehensive analysis of aerobic glycolysis-related genes for prognosis, immune features and drug treatment strategy in prostate cancer

Frontiers in Oncology, 2022
BackgroundThe dysregulated expression of aerobic glycolysis-related genes is closely related to prostate cancer progression and metastasis. However, reliable prognostic signatures based on aerobic glycolysis have not been well established.MethodsWe ...
Wei He, Xiang He, Enhui Li
doaj   +1 more source

Coxsackievirus B3 infection induces glycolysis to facilitate viral replication

Frontiers in Microbiology, 2022
Coxsackievirus B3 (CVB3) is a leading cause of viral myocarditis, but no effective treatment strategy against CVB3 is available. Viruses lack an inherent metabolic system and thus depend on host cellular metabolism for their benefit.
Yujie Qian, Yeyi Yang, Wenxiang Qing, Chunyun Li, Min Kong, Zhijuan Kang, Yuanbojiao Zuo, Jiping Wu, Meng Yu, Zuocheng Yang   +9 more
doaj   +1 more source

The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis

Nature Communications, 2021
Hypoxia-inducible factor-1 (HIF-1) is a master driver of glucose metabolism in cancer cells. Here, we demonstrate that a HIF-1α anti-sense lncRNA, HIFAL, is essential for maintaining and enhancing HIF-1α-mediated transactivation and glycolysis ...
Fang Zheng, Jianing Chen, Xiaoqian Zhang, Zifeng Wang, Jiewen Chen, Xiaorong Lin, Hongyan Huang, Wenkui Fu, Jing Liang, Wei Wu, Bo Li, H. Yao, Hai Hu, E. Song   +13 more
semanticscholar   +1 more source

m6A-dependent glycolysis enhances colorectal cancer progression

Molecular Cancer, 2020
Epigenetic alterations are involved in various aspects of colorectal carcinogenesis. N6-methyladenosine (m6A) modifications of RNAs are emerging as a new layer of epigenetic regulation.
Chao-qin Shen, Baoqin Xuan, Tingting Yan, Yanru Ma, Pingping Xu, Xianglong Tian, Xinyu Zhang, Yingying Cao, Dangdang Ma, Xiaoqiang Zhu, Youwei Zhang, J. Fang, Haoyan Chen, Jie Hong   +13 more
semanticscholar   +1 more source

The fatty acid receptor CD36 promotes HCC progression through activating Src/PI3K/AKT axis-dependent aerobic glycolysis

Cell Death and Disease, 2021
Metabolic reprogramming is a new hallmark of cancer but it remains poorly defined in hepatocellular carcinogenesis (HCC). The fatty acid receptor CD36 is associated with both lipid and glucose metabolism in the liver.
Xiaoqing Luo, Enze Zheng, Li Wei, H. Zeng, H. Qin, Xiaoyu Zhang, Meng Liao, Lin Chen, Lei Zhao, X. Ruan, Ping Yang, Yaxi Chen   +11 more
semanticscholar   +1 more source

PFKM inhibits doxorubicin-induced cardiotoxicity by enhancing oxidative phosphorylation and glycolysis

Scientific Reports, 2022
Heart failure (HF) is a global pandemic which affects about 26 million people. PFKM (Phosphofructokinase, Muscle), catalyzing the phosphorylation of fructose-6-phosphate, plays a very important role in cardiovascular diseases. However, the effect of PFKM
Min Zhou, Xiao Sun, Chunli Wang, Fengdan Wang, Chuibi Fang, Zhenlei Hu   +5 more
doaj   +1 more source

Targeting Glycolysis in Alloreactive T Cells to Prevent Acute Graft-Versus-Host Disease While Preserving Graft-Versus-Leukemia Effect

Frontiers in Immunology, 2022
Alloreactive donor T cells undergo extensive metabolic reprogramming to become activated and induce graft-versus-host disease (GVHD) upon alloantigen encounter.
Ying Huang, Yujing Zou, Yiqun Jiao, Peijie Shi, Xiaoli Nie, Wei Huang, Chuanfeng Xiong, Michael Choi, Charles Huang, Andrew N. Macintyre, Amanda Nichols, Fang Li, Chuan-Yuan Li, Chuan-Yuan Li, Chuan-Yuan Li, Nancie J. MacIver, Nancie J. MacIver, Nancie J. MacIver, Diana M. Cardona, Todd V. Brennan, Zhiguo Li, Nelson J. Chao, Nelson J. Chao, Nelson J. Chao, Nelson J. Chao, Jeffrey C. Rathmell, Benny J. Chen, Benny J. Chen   +27 more
doaj   +1 more source

2-Deoxyglucose alleviates migraine-related behaviors by modulating microglial inflammatory factors in experimental model of migraine

Frontiers in Neurology, 2023
BackgroundTargeting metabolic pathways has emerged as a new migraine treatment strategy as researchers realize the critical role metabolism plays in migraine. Activated inflammatory cells undergo metabolic reprogramming and rely on glycolysis to function.
Tao Qiu, Yanjie Zhou, Luyu Hu, Zhengming Shan, Yu Zhang, Yuting Fang, Wanbin Huang, Lily Zhang, Shanghua Fan, Zheman Xiao   +9 more
doaj   +1 more source