Results 81 to 90 of about 260,676 (239)

MiR-103a-3p promotes tumour glycolysis in colorectal cancer via hippo/YAP1/HIF1A axis

Journal of Experimental & Clinical Cancer Research, 2020
Background Glycolysis plays an essential role in the growth and metastasis of solid cancer and has received increasing attention in recent years. However, the complex regulatory mechanisms of tumour glycolysis remain elusive.
Zhenqiang Sun, Qiuge Zhang, Weitang Yuan, Xiaoli Li, Chen Chen, Yaxin Guo, Bo Shao, Qin Dang, Quanbo Zhou, Qisan Wang, Guixian Wang, Jinbo Liu, Quancheng Kan   +12 more
doaj   +1 more source

Cancer treatment scheduling and dynamic heterogeneity in social dilemmas of tumour acidity and vasculature [PDF]

arXiv, 2016
Background: Tumours are diverse ecosystems with persistent heterogeneity in various cancer hallmarks like self-sufficiency of growth factor production for angiogenesis and reprogramming of energy-metabolism for aerobic glycolysis. This heterogeneity has consequences for diagnosis, treatment, and disease progression.
arxiv  

Bistability in glycolysis pathway as a physiological switch in energy metabolism.

PLoS ONE, 2014
The flux of glycolysis is tightly controlled by feed-back and feed-forward allosteric regulations to maintain the body's glucose homeostasis and to respond to cell's growth and energetic needs.
Bhanu Chandra Mulukutla, Andrew Yongky, Prodromos Daoutidis, Wei-Shou Hu   +3 more
doaj   +1 more source

Enhancing Student Comprehension of Glucose Metabolism Visualization Through Virtual Simulation Platform: An Educational Approach

Pharmacology Research & Perspectives
With the rapid progression of biotechnology, the significance translational research on glycolysis in molecular pharmacology has become increasingly evident.
Luna Ge, Tingting Feng, Shuo Cao, Hang Yin, Yuang Zhang, Jihong Pan, Wei Chen, Kai Cheng, Lin Wang   +8 more
doaj   +1 more source

Renal protective effects of empagliflozin via inhibition of EMT and aberrant glycolysis in proximal tubules.

JCI Insight, 2020
SGLT2 inhibitors are beneficial in halting diabetic kidney disease; complete mechanisms is unknown. The epithelial to mesenchymal transition (EMT) is associated with Sirt3 suppression and aberrant glycolysis.
Jinpeng Li, Haijie Liu, Susumu Takagi, Kyoko Nitta, Munehiro Kitada, S. Srivastava, Y. Takagaki, K. Kanasaki, D. Koya   +8 more
semanticscholar   +1 more source

Isoscopoletin inhibits hepatocellular carcinoma cell proliferation via regulating glycolysis-related proteins.

PLoS ONE
ObjectiveIsoscopoletin is one of the primary metabolites of natural product scoparone, which was reported to against tumor proliferation. The aim of this study was to explore the mechanism of isoscopoletin against hepatocellular carcinoma (HCC ...
Chenyao Ruan, Chen Wang, Jiawen Gu, Zhihui Zhu   +3 more
doaj   +1 more source

STING is a cell-intrinsic metabolic checkpoint restricting aerobic glycolysis by targeting HK2

Nature Cell Biology, 2023
Liting Zhang, Congqing Jiang, Yunhong Zhong, Kongliang Sun, Huiru Jing, Jiayu Song, Jun Xie, Yaru Zhou, Mao Tian, Chuchu Zhang, Xiaona Sun, Shaowei Wang, Xi Cheng, Yuelan Zhang, Wei Wei, Xiang Li, Bishi Fu, P. Feng, Bing Wu, H. Shu, Junjie Zhang   +20 more
semanticscholar   +1 more source

4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects

Nature Communications, 2019
Activated macrophages switch from oxidative phosphorylation to aerobic glycolysis, similar to the Warburg effect, presenting a potential therapeutic target in inflammatory disease.
Shanting Liao, Chao Han, Ding-qiao Xu, Xiaowei Fu, Junsong Wang, Lingyi Kong   +5 more
semanticscholar   +1 more source

Self-organization and fractality created by gluconeogenesis in the metabolic process [PDF]

Chaotic Modeling and Simulation, 2, pp.113-127 (2016), 2017
Within a mathematical model, the process of interaction of the metabolic processes such as glycolysis and gluconeogenesis is studied. As a result of the running of two opposite processes in a cell, the conditions for their interaction and the self-organization in a single dissipative system are created.
arxiv  

Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism

Science, 2016
Metabolic support for T cell functions For immunological T cells, responding to infections is energetically demanding. T cells rewire their metabolism so that they rely more heavily on aerobic glycolysis.
Min Peng, N. Yin, S. Chhangawala, Ke Xu, C. Leslie, Ming O. Li   +5 more
semanticscholar   +1 more source