Results 101 to 110 of about 23,942 (220)

Recent progress in the discovery of macrocyclic compounds as potential anti-infective therapeutics [PDF]

, 2009
Novel therapeutic strategies are urgently needed for the treatment of serious diseases caused by viral, bacterial and parasitic infections, because currently used drugs are facing the problem of rapidly emerging resistance.
Bernardini, F, Bisang, C, DeMarco, S J, Gombert, F O, Moehle, K, Obrecht, D, Robinson, J A   +6 more
core   +1 more source

Epicutaneous and Drug Provocation Testing in Severe Cutaneous Adverse Reactions: A 20‐Year Single‐Centre Experience

Contact Dermatitis, Volume 94, Issue 6, Page 677-688, June 2026.
This study provides reassuring evidence in favour of early skin testing in patients with SCARs, argues against the necessity of a 6‐month delay, and underscores the pivotal role of oral provocation tests in the safe reintroduction of essential therapies. ABSTRACT Background Identifying and discontinuing the offending drug(s) in severe cutaneous adverse
Zohra Chadli, Khadija Mansour, Ghada Jaouahdou, Manel Ben Belgacem, Yosra Soua, Nadia Ben Fredj, Jameleddine Zili, Haifa Ben Romdhane, Karim Aouam   +8 more
wiley   +1 more source

Bactericidal activity of oxacillin and glycopeptides against Staphylococcus aureus in patients with endocarditis: Looking for a relationship between tolerance and outcome [PDF]

, 2011
There is no clear relationship between in vitro bactericidal activity tests and clinical outcome. We studied bactericidal activity of oxacillin, vancomycin and teicoplanin against Staphylococcus aureus isolates in patients with endocarditis and then we ...
Maria Pasticci, Amedeo Moretti, Giuliano Stagni, Veronica Ravasio, Laura Soavi, Annibale Raglio, Francesca Vailati, Angela Cardaccia, Antonella Santucci, Rita Papili, Alessio Sgrelli, Carlo Pallotto, Franco Baldelli   +12 more
core   +1 more source

Hierarchical Channeled Graphitized Nanoarchitecture as a Diagnostic Platform for Maternal Fever Warning

Advanced Science, Volume 13, Issue 26, 8 May 2026.
This study presents a hierarchically channeled graphitized nanoarchitecture (HPGC‐Z67) as a novel nano‐diagnostic platform. It enables sensitive and efficient N‐glycan extraction from plasma, significantly reducing processing time and cost. The platform identifies pivotal N‐glycans to accurately differentiate between infectious and non‐infectious ...
Yiwen Lin, Ning Li, Heyuhan Zhang, Xufang Hu, Zhiqiang Liu, Chunhui Deng   +5 more
wiley   +1 more source

Antimicrobial resistance (AMR) nanomachines: mechanisms for fluoroquinolone and glycopeptide recognition, efflux and/or deactivation [PDF]

, 2018
In this review, we discuss mechanisms of resistance identified in bacterial agents Staphylococcus aureus and the enterococci towards two priority classes of antibiotics—the fluoroquinolones and the glycopeptides.
A Eisner, A Fabrega, A Grove, A Iverson, A Shaheen, A Wohlkonig, AT Ulijasz, B Fournier, B Fournier, B Périchon, BD Bax, BP Howden, C Rayner, CE DeMarco, CM June, CM Tobin, CMO Report, CS Hughes, CT Bergstrom, D Guillemot, D Kahne, D King, DA Beauregard, DC Hooper, DC Hooper, DC Hooper, DM Sievert, DM Sievert, DP Levine, DS Sarovich, E Gullberg, E-W Lee, EMC D’Agata, F Baquero, F Baquero, F Depardieu, FJ Schmitz, FS Aliabadi, G Werner, GA Jacoby, GD Wright, GD Wright, GD Wright, GJ Sharman, GV Crichlow, GW Kaatz, GW Kaatz, GW Kaatz, GW Kaatz, GW Kaatz, H Yoshida, I Laponogov, I Laponogov, I Odenholt, I Tammer, IK Paterson, J Grissom-Arnold, J Haaber, J Huang, J MacDougall, J Strahilevitz, J-J Lu, JH Tran, JJ Goswitz, JL Floyd, JM Rodriguez-Martinez, JP Mackay, K Drlica, K Drlica, K Hiramatsu, K Hiramatsu, K Hiramatsu, K Koteva, K Ubukata, K-C Kaitany, KJ Aldred, KJ Aldred, KJ Aldred, KL Palmer, L Cui, L Fernandez, M Arthur, M Arthur, M Arthur, M Baptista, M Baptista, M Brandenberger, M Mascarello, M Nieto, M Nukaga, M Resch, M Rubtsova, M Rybak, M Trucksis, M-A Negri, MA Schouten, Mary K. Phillips-Jones, MH Lai, MI Andersson, MJ Kwun, MJ Rybak, MK Phillips-Jones, MK Phillips-Jones, MS Ramirez, N Mani, N McCallum, N Noguchi, NE Allen, P Courvalin, P Courvalin, P Geli, P Komp Lindgren, PE Reynolds, PE Reynolds, PJ Loll, PJ Loll, PM Pereira, Q Hu, QC Truong-Boldoc, QC Truong-Boldoc, QC Truong-Boldoc, QC Truong-Bolduc, R Alvarez, R Leclercq, R Peña-Miller, RC Moellering, RN Jones, S Arsene, S Bonhoeffer, S Correira, S Handwerger, S Heeb, S Mladenovic-Antic, S Santos Costa, S Sreedharan, SC Mehta, SJ Hal Van, SL Barnes, SS Ingavale, Stephen E. Harding, T Nishioka, T Tomašić, TM Barbosa, TR Holman, TT Luong, TT Luong, V Pitiriga, VE Anderson, VT Andriole, X Raquet, Y Ding, Y Nitanai, Y Yamada, Y-M Chang, Y-M Chang, Z Jia   +155 more
core   +2 more sources

Integrative Insights Into Bioactive Peptides in Milk Fermented With Autochthonous and Commercial Cultures Using High‐Throughput Peptidomics and Machine Learning

Food Frontiers, Volume 7, Issue 3, May 2026.
This article highlights the crucial role of starter culture selection in shaping the peptide profile of fermented dairy drinks. Using high‐throughput peptidome profiling, the study demonstrates that different starter cultures yield distinct quantities and types of bioactive peptides, with excessive microbial combinations potentially reducing peptide ...
Martina Banić, Ana Butorac, Katarina Butorac, Blaženka Kos, Andreja Leboš Pavunc, Jagoda Šušković, Jasna Novak   +6 more
wiley   +1 more source

Glycoform Modification of Secreted Recombinant Glycoproteins through Kifunensine Addition during Transient Vacuum Agroinfiltration. [PDF]

, 2018
Kifunensine, a potent and selective inhibitor of class I α-mannosidases, prevents α-mannosidases I from trimming mannose residues on glycoproteins, thus resulting in oligomannose-type glycans.
Kailemia, Muchena J, Lebrilla, Carlito B, Li, Qiongyu, McDonald, Karen A, Nandi, Somen, Xiong, Yongao   +5 more
core   +3 more sources

Conjugated 2′‐Fucosyllactose–Potato Protein Hydrolysate as Novel Prebiotics

Food Frontiers, Volume 7, Issue 3, May 2026.
This study introduces a novel protein‐containing prebiotic based on 2′‐FL‐PPH Maillard conjugates micelles that co‐deliver proteins and carbohydrates to the colon to selectively nourish colonic probiotics. These digestion‐resistant micelles enhanced Bifidobacteria, SCFAs, gut barrier integrity, and metabolic health more effectively than conventional ...
Stav Peled, May Cohen‐Hakmon, Ravit Edelman, Yechezkel Kashi, Yoav D. Livney   +4 more
wiley   +1 more source

Antimicrobials in animal agriculture: Parables and policy [PDF]

, 2015
In addition to the scientific, economic, regulatory and other policy factors that impact on antimicrobial decision-making in different jurisdictions around the world, there exist ethical, social and cultural bases for the contemporary use of these ...
Aarestrup, Aarestrup, Aarestrup, Aarestrup, Alali, Amachawadi, Bunner, Cavaco, Checkland, Cottell, Dean, Doyle, Dutil, Food and Drug Administration, Food and Drug Administration, Food and Drug Administration, Food and Drug Administration, G. H. Loneragan, G. Midgley, H. M. Scott, H. Morgan Scott, Hollway, Hurd, Hurd, Jaap A. Wagenaar, Jan, Jan, Kanwar, Kanwar, Keelara, Lowrance, Maturana, McIntosh, Midgley, Midgley, Midgley, Midgley, Platt, Popper, Ulrich, Von Foerster, Von Glasersfeld, World Health Organization, World Health Organization   +43 more
core   +1 more source

Targeting of Gut Microbiota by Bioactive Peptides for the Improvement of Metabolic Diseases: A Review

Food Frontiers, Volume 7, Issue 3, May 2026.
Bioactive peptides (BPs) derived from dietary proteins modulate the gut microbiotametabolism axis by reshaping microbial composition and regulating key metabolites, including short‐chain fatty acids. BPs also enhance intestinal barrier integrity and immune homeostasis, thereby reducing inflammation.
Jiao Li, Yongchao Chen, Zhihua Li, Gang Liu, Hongmei Jiang, Jun Fang, Sujuan Ding   +6 more
wiley   +1 more source