Results 71 to 80 of about 20,845 (201)
ChemBioChem, Volume 27, Issue 15, 14 August 2026.A flow cytometry technique was developed to measure the binding of vancomycin‐formyl peptide conjugates to the surface of resistant Staphylococcus aureus. Binding results indicate that the labelling site of the vancomycin targeting element has a major effect on binding to the bacterial cell wall, which correlates with reduced antibiotic activity ...
Winfrey P. Y. Hoo +9 more
wiley +1 more source
An optimal method for generating stable vancomycin heteroresistance and intermediate susceptibility in methicillin-resistant Staphylococcus aureusblood isolates under in-vitro vancomycin pressure [PDF]
Journal of Microbiology and Infectious Diseases, 2012 Objectives: The relevance of vancomycin intermediately-susceptible (VISA) and hetero-resistant (hVISA) methicillin-resistantStaphylococcus aureus (MRSA) remains uncertain because of their low frequency. In vitro attempts to generate reducedsusceptibility
Riad Khatib +4 more
doaj
Old and New Glycopeptide Antibiotics: Action and Resistance
Antibiotics, 2014 Glycopeptides are considered antibiotics of last resort for the treatment of life-threatening infections caused by relevant Gram-positive human pathogens, such as Staphylococcus aureus, Enterococcus spp. and Clostridium difficile.
Elisa Binda +2 more
doaj +1 more source
ChemMedChem, Volume 21, Issue 15, 14 August 2026.Fragmentation of the natural product vancoresmycin reveals an essential role of global architecture for biological potency. Vancoresmycin is a structurally complex tetramic‐acid‐containing natural product with potent activity against Gram‐positive bacteria, yet its structure–activity relationships remain poorly defined.
Max Schönenbroicher +8 more
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 30, 20 July 2026.A reducible solubilizing tag strategy (RST‐2.0) enables the synthesis, purification and ligation of difficult peptides while being readily removable just during folding, which overcomes the common challenges from protein hydrophobicity and aggregation. With this method, we achieved the first total synthesis of native and N‐glycosylated IL‐15 as well as
Jingwen Zeng +4 more
wiley +2 more sources
Editorial: Recent advances in carbohydrate chemical and enzymatic syntheses
Frontiers in Chemistry, 2023 M. Carmen Galan +2 more
doaj +1 more source
AntibioticsOptimizing antibiotic therapy is imperative with rising bacterial resistance and high infection mortality. Extended infusion defined as a continuous infusion (COI) or prolonged infusion (PI) of beta-lactams and glycopeptides might improve efficacy and ...
Andrea Rahel Burch +3 more
doaj +1 more source
Chirality, Volume 38, Issue 8, August 2026.A green chiral HPLC method was developed and validated for the determination of lumefantrine enantiomers. The method employs ethanol as a mobile phase as a sustainable and efficient alternative to hexane. The chiral recognition mechanism and elution order of the enantiomers were investigated using electronic circular dichroism and molecular docking ...
Amanda Mohr +4 more
wiley +1 more source
Drug Development Research, Volume 87, Issue 5, August 2026.ABSTRACT Drug‐resistant bacteria such as Methicillin‐resistant Staphylococcus aureus (MRSA) and Quinolone‐resistant S. aureus (QRSA), are a growing problem, creating a need for the development of novel antimicrobial agents. In this study, we designed and synthesized two novel 1,4‐naphthoquinone derivatives, LHN‐1034 and LHN‐1035, and evaluated their ...
HyunChan Song +5 more
wiley +1 more source
Allergenicity of α‐Gal‐Containing Products
Allergy, EarlyView.
Frederik Bloch Mangaard +4 more
wiley +1 more source