Results 131 to 140 of about 111,765 (333)

Hinokitiol is a novel glycoprotein VI antagonist on human platelets

Platelets, 2014
Hinokitiol (4-isopropyl-tropolone) is a bioactive compound with various pharmacological activities that is found in the wood of cupressaceous plants. Platelet activation plays an important role in thrombogenesis. In our previous study, hinokitiol specifically inhibited collagen-induced platelet aggregation ex vivo and prolonged thrombogenesis in vivo ...
Wan-Jung Lu, Hsiu Chu Chou, Joen Rong Sheu, Kuan Hung Lin, Yu Chen Lin, Ming Ping Wu   +5 more
openaire   +3 more sources

Screening and evaluation of potential clinically significant HIV drug combinations against SARS-CoV-2 virus [PDF]

arXiv, 2020
In this study, we investigated the inhibition of SARS-CoV-2 spike glycoprotein with HIV drugs and their combinations. This glycoprotein is essential for the reproduction of the SARS-COV-2 virus, so its inhibition opens new avenues for the treatment of patients with COVID-19 disease.
arxiv  

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

Advanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana, Indra Apsite, Leonid Ionov   +2 more
wiley   +1 more source

Effect of verapamil on systemic exposure and safety of umeclidinium and vilanterol: a randomized and open-label study

International Journal of COPD, 2013
Rashmi Mehta,1 Dennis Kelleher,1 Andrew Preece,2 Stephen Hughes,3 Glenn Crater4 1Respiratory Medicines Development Center, GlaxoSmithKline, Research Triangle Park, NC, USA; 2Respiratory Medicines Development Center, GlaxoSmithKline, Stockley Park West ...
Mehta R, Kelleher D, Preece A, Hughes S, Crater G   +4 more
doaj  

Comparative Analysis of Microfluidics Thrombus Formation in Multiple Genetically Modified Mice: Link to Thrombosis and Hemostasis

Frontiers in Cardiovascular Medicine, 2019
Genetically modified mice are indispensable for establishing the roles of platelets in arterial thrombosis and hemostasis. Microfluidics assays using anticoagulated whole blood are commonly used as integrative proxy tests for platelet function in mice ...
Magdolna Nagy, Johanna P. van Geffen, David Stegner, David J. Adams, Attila Braun, Susanne M. de Witt, Margitta Elvers, Mitchell J. Geer, Marijke J. E. Kuijpers, Karl Kunzelmann, Jun Mori, Cécile Oury, Joachim Pircher, Irina Pleines, Alastair W. Poole, Yotis A. Senis, Remco Verdoold, Christian Weber, Christian Weber, Bernhard Nieswandt, Johan W. M. Heemskerk, Constance C. F. M. J. Baaten, Constance C. F. M. J. Baaten   +22 more
doaj   +1 more source

Apolipoprotein E mediates evasion from hepatitis C virus−neutralizing antibodies [PDF]

, 2016
Background & Aims Efforts to develop an effective vaccine against hepatitis C virus (HCV) have been hindered by the propensity of the virus to evade host immune responses. HCV particles in serum and in cell culture associate with lipoproteins, which
Bartenschlager, Ralf, Baumert, Thomas F., Crouchet, Emilie, Fauvelle, Catherine, Felmlee, Daniel J., Fofana, Isabel, Foung, Steven K.H., Habersetzer, François, Heydmann, Laura, Hiet, Marie-Sophie, Lee, JiYoung, Lefèvre, Mathieu, Magri, Andrea, Meuleman, Philip, Milne, Ross, Patel, Arvind H., Schuster, Catherine, Vercauteren, Koen, Zeisel, Mirjam B.   +18 more
core   +3 more sources

A Comparison of the Mechanical Properties of ECM Components and Synthetic Self‐Assembling Peptides

Advanced Healthcare Materials, EarlyView.
Self‐assembling peptide hydrogels are increasingly utilized in biomedical applications. The authors review the key mechanical properties of these structures across multiple size scales and compare them to that of native extracellular matrix components, which are found to display a much wider range of structural attributes.
Alex Hartley, Philip Michael Williams, Alvaro Mata   +2 more
wiley   +1 more source

Detection and first characterization of an uncommon haptoglobin in porcine saliva of pigs with rectal prolapse by using boronic acid sample enrichment

Animal, 2017
Salivary glycoprotein profiles, obtained after boronic acid enrichment, were studied for the first time in pigs in order to search for specific overall alterations related to acute inflammatory condition.
A.M. Gutiérrez, I. Miller, D. Kolarich, K. Hummel, K. Nöbauer, E. Razzazi-Fazeli   +5 more
doaj  

Administration of Vitamin D Metabolites Affects RNA Expression of Xenobiotic Metabolising Enzymes and Function of ABC Transporters in Rats [PDF]

, 2019
From studies on different species and in cell culture systems, it has been suggested that vitamin D metabolites might affect themetabolism and elimination of xenobiotics.
Hansen, Kathrin, Klumpp, Karoline, Lange, Frauke, Lifschitz, Adrian Luis, Maté, María Laura, Muscher-Banse, Alexandra S., Schnepel, Nadine, Wilkens, Mirja   +7 more
core   +1 more source

Graded Hydroxyapatite Triply Periodic Minimal Surface Structures for Bone Tissue Engineering Applications

Advanced Healthcare Materials, EarlyView.
This study investigates the role of triply periodic minimal structures in load bearing bone tissue engineering applications. Research uses a combination of mechanical testing, material characterization, and in vitro tests to study the impact of TPMS lattice structures (gyroid, lidinoid and split‐P).
Tejas M. Koushik, Catherine M. Miller, Elsa Antunes   +2 more
wiley   +1 more source