The V5A13.1 envelope glycoprotein deletion mutant of mouse hepatitis virus type-4 is neuroattenuated by its reduced rate of spread in the central nervous system. [PDF]
, 1992 Following intracerebral inoculation of adult Balb/c Byj mice, the MHV-4 strain of mouse hepatitis virus (MHV) had an LD50 of less than 0.1 PFU, whereas its monoclonal antibody resistant variant V5A13.1 had an LD50 of 10(4.2) PFU.
Bloom, F +3 more
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Potentiation of thrombus instability: a contributory mechanism to the effectiveness of antithrombotic medications [PDF]
, 2018 © The Author(s) 2018The stability of an arterial thrombus, determined by its structure and ability to resist endogenous fibrinolysis, is a major determinant of the extent of infarction that results from coronary or cerebrovascular thrombosis.
A Gast +66 more
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Haematologica, 2010 Background The collagen receptor glycoprotein VI generates activating signals through an immunoreceptor tyrosine-based activating motif on the co-associated Fc receptor gamma chain.
Tessa A.M. Steevels +6 more
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Polymerized fibrin activates glycoprotein VI [PDF]
Blood, 2015 In this issue of Blood , [Mammadova-Bach et al][1] show that polymerized fibrin binds to the platelet receptor glycoprotein VI (GPVI), amplifying thrombin generation and enhancing thrombus growth.[1][2] ![Figure][3] GPVI amplifies thrombin generation and platelet aggregation. PS,
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Expression of the murine cytomegalovirus glycoprotein H by recombinant vaccinia virus [PDF]
, 1994 The sequence of the gene encoding glycoprotein H (gH) of murine cytomegalovirus (MCMV) strain Smith was determined and compared with the sequence of the gH of MCMV strain K181. Transcriptional analysis showed that gH is encoded by a large mRNA of 5.0 kb,
Koszinowski, Ulrich H. +4 more
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Sanguinarine Attenuates Collagen-Induced Platelet Activation and Thrombus Formation
Biomedicines, 2021 Sanguinarine, a benzophenanthridine alkaloid, has been described to have an antiplatelet activity. However, its antithrombotic effect and the mechanism of platelet inhibition have not thoroughly been explored.
Dan Shu +9 more
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Glycoprotein VI oligomerization in cell lines and platelets [PDF]
Journal of Thrombosis and Haemostasis, 2007 Glycoprotein VI (GPVI) is a physiologic receptor for collagen expressed at the surface of platelets and megakaryocytes. Constitutive dimerization of GPVI has been proposed as being necessary for the interaction with collagen, although direct evidence of dimerization has not been reported in cell lines or platelets.To investigate oligomerization of GPVI
Berlanga, O +6 more
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The relationship between platelet glycoprotein VI T13254C polymorphism and acute myocardial infarction (MI) [PDF]
پیاورد سلامت, 2011 Background and Aim: Myocardial infarction (MI) is a major cause of morbidity and mortality worldwide. Epidemiological studies indicate that MI results from complex interactions between long-term environmental influences, concomitant disorders, and ...
A Fatemi +4 more
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Increased platelet reactivity as measured by plasma glycoprotein VI in gout
Platelets, 2018 Patients with gout have an increased risk of cardiovascular events. The glycoprotein VI (GPVI) receptor is found exclusively on platelets and megakaryocytes, is proteolytically cleaved upon platelet activation, and detectable in plasma as soluble GPVI ...
Richard Conway +10 more
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Posttranslational modifications of platelet adhesion receptors
Pharmacological Research, 2022 Platelets play a key role in normal hemostasis, whereas pathological platelet adhesion is involved in various cardiovascular events. The underlying cause in cardiovascular events involves plaque rupture leading to subsequent platelet adhesion, activation,
Shukun Sun +5 more
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