Results 31 to 40 of about 111,040 (333)
Absence of bleeding upon dual antiplatelet therapy in a patient with a immune GPVI deficiency
Platelets, 2021 Acquired deficiencies in platelet glycoprotein VI are rare and have not been found associated with other defects. Here we report the case of a 64-year old male patient presenting an immune GPVI deficiency associated to a mutation in the alpha-actinin ...
Stéphane Loyau Inserm +5 more
doaj +1 more source
Impaired Glycoprotein VI-Mediated Signaling and Platelet Functional Responses in CD45 Knockout Mice. [PDF]
Thromb Haemost, 2019 Inamdar VV +7 more
europepmc +3 more sources
Variation in Human Platelet Glycoprotein VI Content Modulates Glycoprotein VI–Specific Prothrombinase Activity [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2001 Glycoprotein VI (GPVI) is a platelet-specific receptor for collagen that figures prominently in signal transduction. An addition to binding to type I and III collagens, GPVI is also bound specifically by collagen-related peptide and convulxin (CVX), a snake venom protein.
Hiroshi Deguchi +3 more
openaire +3 more sources
Platelets, 2023 The association between endometriosis and autoimmune diseases is well known, however no acquired platelet function defect has been described so far. We describe the case of two patients with endometriosis associated with an antiplatelet glycoprotein VI ...
Stéphane Loyau +12 more
doaj +1 more source
Glycoprotein VI oligomerization in cell lines and platelets [PDF]
Journal of Thrombosis and Haemostasis, 2007 Glycoprotein VI (GPVI) is a physiologic receptor for collagen expressed at the surface of platelets and megakaryocytes. Constitutive dimerization of GPVI has been proposed as being necessary for the interaction with collagen, although direct evidence of dimerization has not been reported in cell lines or platelets.To investigate oligomerization of GPVI
Berlanga, O +6 more
openaire +4 more sources
A natural ionic liquid: low molecular mass compounds of aggregate glue droplets on spider orb webs [PDF]
, 2022 The aggregate glue of spider orb web is an excellent natural adhesive. Orb-weaver spiders use micron-scale aggregate glue droplets to retain prey in the capture spiral silks of their orb web. In aggregate glue droplets, highly glycosylated and phosphorylated proteins dissolve in low molecular mass compounds.
arxiv +1 more source
Platelet glycoprotein VI‐related clinical defects [PDF]
British Journal of Haematology, 2007 SummaryHuman patients with defects associated with the platelet collagen receptor, glycoprotein (GP)VI, are rare and usually described as having a mild bleeding disorder. However, here we review clinical profiles of patients with familial or acquired GPVI defects, revealing the bleeding defect is often severe and associated with immune dysfunction ...
Scott Dunkley +2 more
openaire +3 more sources
Ibrutinib-associated alveolar hemorrhage and spontaneous hemothorax
Polish Journal of Thoracic and Cardiovascular Surgery, 2022 Ibrutinib is an irreversible inhibitor of Bruton’s tyrosine kinase (BTK), a cytoplasmic tyrosine kinase of the Tec family, which plays an important role in the B-cell receptor signaling pathway [1].
Ismail Tombul +5 more
doaj +1 more source
Psoralen and ultraviolet A light treatment directly affects phosphatidylinositol 3-kinase signal transduction by altering plasma membrane packing [PDF]
, 2016 Psoralen and ultraviolet A light (PUNTA) are used to kill pathogens in blood products and as a treatment of aberrant cell proliferation in dermatitis, cutaneous T-cell lymphoma, and graft versus-host disease.
Compernolle, Veerle +7 more
core +2 more sources
Haematologica, 2010 Background The collagen receptor glycoprotein VI generates activating signals through an immunoreceptor tyrosine-based activating motif on the co-associated Fc receptor gamma chain.
Tessa A.M. Steevels +6 more
doaj +1 more source