Results 31 to 40 of about 42,353 (227)

Antiplatelet Activity of Tussilagone via Inhibition of the GPVI Downstream Signaling Pathway in Platelets

Frontiers in Medicine, 2020
Tussilagone is a sesquiterpenoid extracted from Tussilago farfara and is used as an oriental medicine for asthma and bronchitis. Although previous studies have shown that tussilagone has an inhibitory effect on platelet aggregation, no studies have been ...
Jing Zhou, Ru-Ping Yang, Wei Song, Hui-Min Xu, Yong-Hui Wang   +4 more
doaj   +1 more source

Enhanced stability of the SARS CoV-2 spike glycoprotein following modification of an alanine cavity in the protein core.

PLoS Pathogens, 2023
The spike (S) glycoprotein of SARS CoV-2 is the target of neutralizing antibodies (NAbs) that are crucial for vaccine effectiveness. The S1 subunit binds ACE2 while the S2 subunit mediates virus-cell membrane fusion.
Pantelis Poumbourios, Christine Langer, Irene Boo, Tasnim Zakir, Rob J Center, Anouschka Akerman, Vanessa Milogiannakis, Anupriya Aggarwal, Bronte A Johnstone, Jungmin Ha, Fasséli Coulibaly, Stuart G Turville, Heidi E Drummer   +12 more
doaj   +1 more source

Platelet glycoprotein VI genetic quantitative and qualitative defects

Platelets, 2019
Platelet membrane glycoprotein VI (GPVI) is increasingly recognized as an important receptor for thrombus formation and growth. Numerous arguments have been published indicating that GPVI plays a major role in thrombosis without being essential for ...
Martine Jandrot-Perrus, Cedric Hermans, Diego Mezzano   +2 more
doaj   +1 more source

An optimized herbal medicine containing Scutellaria baicalensis Georgi, Alisma orientale Juzepzuk, and Atractylodes japonica Koidzumi has potent antiplatelet and antithrombotic activities

Journal of Traditional and Complementary Medicine, 2023
Background and aim: Platelet-derived thrombosis is important in the pathogenesis of cardiovascular diseases. HTB is an optimized herbal medicine including Scutellaria baicalensis Georgi, Alisma orientale Juzepzuk, and Atractylodes japonica Koidzumi.
Yeon-Ji Kim, Tae In Kim, Kyungho Kim
doaj   +1 more source

Biomechanical thrombosis: the dark side of force and dawn of mechano-medicine

Stroke and Vascular Neurology, 2020
Arterial thrombosis is in part contributed by excessive platelet aggregation, which can lead to blood clotting and subsequent heart attack and stroke. Platelets are sensitive to the haemodynamic environment.
Yunfeng Chen, Lining Arnold Ju
doaj   +1 more source

Cross-Linking GPVI-Fc by Anti-Fc Antibodies Potentiates Its Inhibition of Atherosclerotic Plaque- and Collagen-Induced Platelet Activation

JACC: Basic to Translational Science, 2016
To enhance the antithrombotic properties of recombinant glycoprotein VI fragment crystallizable (GPVI-Fc), the authors incubated GPVI-Fc with anti-human Fc antibodies to cross-link the Fc tails of GPVI-Fc.
Janina Jamasbi, RPh, Remco T.A. Megens, PhD, Mariaelvy Bianchini, MSc, Kerstin Uhland, PhD, Götz Münch, MD, Martin Ungerer, MD, Shachar Sherman, BSc, Alexander Faussner, PhD, Richard Brandl, MD, Christine John, MSc, Johannes Buchner, PhD, Christian Weber, MD, Reinhard Lorenz, MD, Natalie Elia, PhD, Wolfgang Siess, MD   +14 more
doaj   +1 more source

Restrained glycoprotein VI-induced platelet signaling by tyrosine protein phosphatases independent of phospholipase Cγ2

Bleeding, Thrombosis and Vascular Biology, 2023
The platelet collagen receptor glycoprotein VI (GPVI) signals to activation of phospholipase Cγ2 (PLCγ2) and phosphoinositide 3-kinases (PI3K), causing platelet activation and aggregation.
Jingnan Huang, Delia I. Fernández, Jinmi Zou, Xueqing Wang, Johan W.M. Heemskerk, Ángel García   +5 more
doaj   +1 more source

Thymosin β4 is essential for thrombus formation by controlling the G-actin/F-actin equilibrium in platelets

Haematologica, 2021
Coordinated rearrangements of the actin cytoskeleton are pivotal for platelet biogenesis from megakaryocytes but also orchestrate key functions of peripheral platelets in hemostasis and thrombosis, such as granule release, the formation of filopodia and
Inga Scheller, Sarah Beck, Vanessa Göb, Carina Gross, Raluca A. I. Neagoe, Katja Aurbach, Markus Bender, David Stegner, Zoltan Nagy, Bernhard Nieswandt   +9 more
doaj   +1 more source

Detection and first characterization of an uncommon haptoglobin in porcine saliva of pigs with rectal prolapse by using boronic acid sample enrichment

Animal, 2017
Salivary glycoprotein profiles, obtained after boronic acid enrichment, were studied for the first time in pigs in order to search for specific overall alterations related to acute inflammatory condition.
A.M. Gutiérrez, I. Miller, D. Kolarich, K. Hummel, K. Nöbauer, E. Razzazi-Fazeli   +5 more
doaj   +1 more source

Influence of Vincristine, Clinically Used in Cancer Therapy and Immune Thrombocytopenia, on the Function of Human Platelets

Molecules, 2021
Vincristine is a clinically used antimicrotubule drug for treating patients with lymphoma. Due to its property of increasing platelet counts, vincristine is also used to treat patients with immune thrombocytopenia.
Li-Ming Lien, Wan-Jung Lu, Kuan-Hung Lin, Ling-Hsuan Kang, Ting-Yu Chen, Bo-Jung Lin, Yung-Chang Lu, Chun-Yao Huang, Chun-Ming Shih, Hsuan Chen, Yao-Chou Tsai, Ray-Jade Chen, Joen-Rong Sheu   +12 more
doaj   +1 more source