Results 151 to 160 of about 116,862 (285)

Relationship of glycosaminoglycan and matrix changes to vascular smooth muscle cell phenotype modulation in rabbit arteries after acute injury [PDF]

, 2001
John Bingley, Ian P. Hayward, Gordon Campbell, Julie H. Campbell   +3 more
openalex   +1 more source

Engineering Bacteria as Living Therapeutics in Cancer Therapy

Advanced Science, EarlyView.
Through synthetic biology approaches, natural bacteria can be genetically programmed into multifunctional living therapeutics. These engineered bacteria are capable of secreting anti‐tumor factors, displaying tumor‐associated antigens on their surface, or undergoing programmed self‐lysis to release therapeutic cargo.
Jiangfeng Chen, Jiaqi Chen, Yixuan Chen, Wenxuan Yuan, Jiao Zhang, Guoqing Wang, Zhuojun Dai   +6 more
wiley   +1 more source

Stimulation of Extracellular Matrix Synthesis in the Developing Cornea by Glycosaminoglycans

, 1974
Stephen Meier, Elizabeth D. Hay
openalex   +2 more sources

Peptide Electrostatic Modulation Directs Human Neural Cell Fate

Advanced Science, EarlyView.
This study explores the effect of charge on the bioactivity of peptide‐based supramolecular materials. The design of a peptide library with varying charges that self‐assemble into supramolecular fibers is presented, demonstrating how the surface charge of these fibers, used as artificial extracellular matrices, influences the fate of human neural ...
Laura Perez‐Chirinos, Xavier Barceló, M. Gabriella Chiariello, Irene Sanz, Amaia Iturrospe, Arantxa Arbe, J. Alberto Ortega, Siewert J. Marrink, Aitziber L. Cortajarena, Zaida Álvarez, Ivan R. Sasselli   +10 more
wiley   +1 more source

Xylosyltransferase-Deficiency in Human Dermal Fibroblasts Induces Compensatory Myofibroblast Differentiation and Long-Term ECM Reduction

Biomedicines
Desbuquois dysplasia type 2 (DBQD2) and spondylo-ocular syndrome (SOS) are autosomal recessive disorders affecting the extracellular matrix (ECM) and categorized as glycosaminoglycan (GAG) linkeropathies.
Anika Kleine, Matthias Kühle, Thanh-Diep Ly, Vanessa Schmidt, Isabel Faust-Hinse, Cornelius Knabbe, Bastian Fischer   +6 more
doaj   +1 more source

Constructing Dual‐Atomic Fe─Fe Sites Nanozyme for Targeted Osteoarthritis Therapy through Mitigating Oxidative Stress and Cartilage Degeneration

Advanced Science, EarlyView.
A novel bimetallic nanozyme (Fe2–NCs) with well‐defined Fe–Fe active sites is synthesized through a host–guest coordination strategy, which exhibits an exceptional therapeutic efficacy in osteoarthritis therapy. Experimental and theoretical analyses uncover the intrinsic catalytic mechanism at the atomic level, offering fundamental insights and design ...
Ting Ying, Qi Wang, Dejian Li, Yao Wang, Pengfang Zhang, Chengqing Yi, Rui Zhu   +6 more
wiley   +1 more source

New horizons in spine research: Intervertebral disc repair and regeneration. [PDF]

, 2017
Iatridis, James C, Kandel, Rita, Kang, James, Risbud, Makarand V.   +3 more
core   +2 more sources

Shear Conditioning Promotes Microvascular Endothelial Barrier Resilience in a Human BBB‐on‐a‐Chip Model of Systemic Inflammation Leading to Astrogliosis

Advanced Science, EarlyView.
Physiological flow (0.5 Pa) conditioning promotes resilience of an iPSC‐derived blood–brain barrier endothelium to mild systemic inflammation. In contrast, high “cytokine storm” levels induce barrier breakdown, fibrinogen leakage, and astrocyte activation, reconstituting the two‐hit injury mechanism on‐a‐chip.
Kaihua Chen, Isabelle M. Linares, Michelle A. Trempel, Alexis M. Feidler, Dinindu De Silva, Sami Farajollahi, Jordan Jones, Julia Kuebel, Pelin Kasap, Britta Engelhardt, Jonathan Flax, Vinay V. Abhyankar, Richard E. Waugh, Harris A. Gelbard, Niccolo Terrando, James L. McGrath   +15 more
wiley   +1 more source

Strain Variation in Glycosaminoglycan Recognition Influences Cell-Type-Specific Binding by Lyme Disease Spirochetes [PDF]

, 1999
Nikhat Parveen, Douglas R. Robbins, John M. Leong   +2 more
openalex   +1 more source

Constructing 3-Dimensional Atomic-Resolution Models of Nonsulfated Glycosaminoglycans with Arbitrary Lengths Using Conformations from Molecular Dynamics [PDF]

, 2020
Elizabeth K. Whitmore, Devon Martin, Olgun Guvench   +2 more
openalex   +1 more source