Results 171 to 180 of about 90,028 (262)

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

British Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher, Mérone Da Costa Oliveira, Adrien Levesque, Alexandre Rutault, Patrick Savoyaud, Nicolas Bréchot, Stéphane Germain   +6 more
wiley   +1 more source

Tocilizumab in refractory pretibial myxedema: new therapeutic insights. [PDF]

JCEM Case Rep
Corrias S, Arba A, Lixi F, Giannaccare G, Boi F, Lanzolla G.   +5 more
europepmc   +1 more source

Liquid Biopsy and Multi‐Cancer Early Detection Tests for Cancer Screening: A Scoping Review

Clinical Genetics, EarlyView.
There is a large body of evidence on liquid biopsy and multi‐cancer detection tests for cancer screening. Most studies addressed test performance outcomes, while fewer addressed clinical outcomes, implementation, and cost‐effectiveness. No studies evaluated cancer mortality.
Tessa Robinson, Marian Saab, Lily Thao Nguyen, Pooja Kochar, Olivia Meggetto, Jill Tinmouth, Meghan J. Walker   +6 more
wiley   +1 more source

Morquio syndrome masquerading as juvenile idiopathic Arthritis: A case report. [PDF]

Radiol Case Rep
Kadiri ZA, El Binoune I, Amine B, Kabbaj A, Zemrani S, Rostom S, Rachid B.   +6 more
europepmc   +1 more source

Ammonia Accumulation Drives Intervertebral Disc Degeneration by Triggering Ammonia‐Induced Cell Death Through Lysosome–Mitochondria Crosstalk

Cell Proliferation, EarlyView.
Mechanical strain disrupts the lysosome‐mitochondria axis via GLS1‐mediated ammonia toxicity, causing NP cell death and ECM breakdown in IVDD. CB839‐mediated GLS1 inhibition effectively rescues cellular homeostasis and alleviates disc degeneration.
Yang Zhang, Yucheng Gao, Shuhang Dong, Shuanggong Liu, Lei Liu, Ziyi Song, Jie Xu, Yijun Rong, Guangxu Song, Yingze Zhang, Dongjin Wu, Zengxin Gao   +11 more
wiley   +1 more source

A sulfated chitosan-driven immune-ECM reprogramming strategy to break the vicious cycle of aged wound healing. [PDF]

Bioact Mater
Zhang X, Wang S, Liu Y, Wang J, Liu C.
europepmc   +1 more source

In Vitro Evaluation of the Efficacy of Liquid Platelet‐Rich Fibrin (PRF) for Maintaining and Restoring Periodontal Ligament Cell Viability in Avulsed Teeth After 3 and 4 h of Extra‐Alveolar Dry Time

Dental Traumatology, EarlyView.
ABSTRACT Background/Aim This in vitro study evaluated whether liquid platelet‐rich fibrin could maintain or recover periodontal ligament cell viability in extracted human teeth after three and four hours of dry extra‐alveolar time. Material and Methods Sixty‐six erupted third molars with complete root formation were allocated to four groups: three‐hour
Tatiana Carvalho Kowaltschuk, Mariana Martins Juglair, Daniel Grigolo, Fabiane Barchiki, Lorena Bortolini Navarro, Everdan Carneiro, Vânia Portela Ditzel Westphalen   +6 more
wiley   +1 more source

Noonan Syndrome Type 5 Diagnosed by Next-Generation Sequencing: A Report of a Rare Pediatric Case. [PDF]

Cureus
Kheir S, Ahmidi J, Tajir M, Rkain M, Babakhouya A.   +4 more
europepmc   +1 more source

Treatment approaches for equine subchondral lucencies: Clinical considerations and therapeutic decision‐making

Equine Veterinary Education, EarlyView.
Summary Subchondral lucencies, also referred to as subchondral cystic lesions or osseous cyst‐like lesions, are radiographically identifiable defects of subchondral bone that remain an important cause of lameness and reduced athletic performance in horses.
C. Salazar‐Latorre, R. Salcedo‐Jiménez, M. Masri‐Daba   +2 more
wiley   +1 more source

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source