Results 31 to 40 of about 85,742 (348)

Bioinformatics of glycosaminoglycans

Perspectives in Science, 2017
SummaryCell surface heparan sulfates modulate many signalling pathways by binding growth factors and growth factor receptors. Expressed in a spatially and temporally regulated manner, these highly sulfated polysaccharides play important roles in all aspects of animal physiology.
Han Hu, Joseph Zaia, Yang Mao, Yu Huang, Cheng Lin   +4 more
openaire   +2 more sources

Heparan Sulfate Proteoglycans Biosynthesis and Post Synthesis Mechanisms Combine Few Enzymes and Few Core Proteins to Generate Extensive Structural and Functional Diversity

Molecules, 2020
Glycosylation is a common and widespread post-translational modification that affects a large majority of proteins. Of these, a small minority, about 20, are specifically modified by the addition of heparan sulfate, a linear polysaccharide from the ...
Thibault Annaval, Rebekka Wild, Yoann Crétinon, Rabia Sadir, Romain R. Vivès, Hugues Lortat-Jacob   +5 more
doaj   +1 more source

Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides [PDF]

, 2020
Despite evident regulatory roles of heparan sulfate (HS) saccharides in numerous biological processes, definitive information on the bioactive sequences of these polymers is lacking, with only a handful of natural structures sequenced to date.
Grabarics, Márkó, Guimond, Scott E., Hofmann, Johanna, Manz, Christian, Miller, Rebecca L., Pagel, Kevin, Schwörer, Ralf, Tyler, Peter C., Xu, Yongmei [u.v.m.], Zubkova, Olga V.   +9 more
core   +1 more source

Proton Conductivity of Glycosaminoglycans [PDF]

PLOS ONE, 2018
AbstractProton (H+) conductivity is important in many natural phenomena including oxidative phosphorylation in mitochondria and archea, uncoupling membrane potentials by the antibiotic Gramicidin, and proton actuated bioluminescence in dinoflagellate.
Selberg, John, Jia, Manping, Rolandi, Marco   +2 more
openaire   +4 more sources

Clearance of Heparan Sulfate and Attenuation of CNS Pathology by Intracerebroventricular BMN 250 in Sanfilippo Type B Mice

Molecular Therapy: Methods & Clinical Development, 2017
Sanfilippo syndrome type B (mucopolysaccharidosis IIIB), caused by inherited deficiency of α-N-acetylglucosaminidase (NAGLU), required for lysosomal degradation of heparan sulfate (HS), is a pediatric neurodegenerative disorder with no approved treatment.
Mika Aoyagi-Scharber, Danielle Crippen-Harmon, Roger Lawrence, Jon Vincelette, Gouri Yogalingam, Heather Prill, Bryan K. Yip, Brian Baridon, Catherine Vitelli, Amanda Lee, Olivia Gorostiza, Evan G. Adintori, Wesley C. Minto, Jeremy L. Van Vleet, Bridget Yates, Sara Rigney, Terri M. Christianson, Pascale M.N. Tiger, Melanie J. Lo, John Holtzinger, Paul A. Fitzpatrick, Jonathan H. LeBowitz, Sherry Bullens, Brett E. Crawford, Stuart Bunting   +24 more
doaj   +1 more source

Glycosaminoglycans and Contrast Agents: The Role of Hyaluronic Acid as MRI Contrast Enhancer

Biomolecules, 2020
A comprehensive understanding of the behaviour of Glycosaminoglycans (GAGs) combined with imaging or therapeutic agents can be a key factor for the rational design of drug delivery and diagnostic systems.
Alfonso Maria Ponsiglione, Maria Russo, Enza Torino   +2 more
doaj   +1 more source

Variation and development of the turtle chondrocranium, with a description of the common musk turtle (Sternotherus odoratus, Kinosternidae, Cryptodira, Testudines)

The Anatomical Record, EarlyView., 2023
Abstract Based on histological cross‐sections, the chondrocranium of the common musk turtle (Sternotherus odoratus) was reconstructed, described, and compared with other turtles. It differs from that of other turtle chondrocrania by possessing elongated, slightly dorsally orientated nasal capsules with three dorsolateral foramina, which might be ...
Luca Leicht, Zitong Zhang, Ingmar Werneburg   +2 more
wiley   +1 more source

The Development of Assays for Heparanase Enzymatic Activity: Towards a Gold Standard

Molecules, 2018
The enzyme heparanase, an endo-β-glucuronidase, degrades heparan sulfate (HS) chains on the cell surface and in the extracellular matrix. Heparanase regulates numerous biological processes that drive tumour growth, metastasis and angiogenesis.
Mohit Chhabra, Vito Ferro
doaj   +1 more source

Glycosaminoglycan Modification of Decorin Depends on MMP14 Activity and Regulates Collagen Assembly

Cells, 2020
Proper processing of collagens COL1 and COL6 is required for normal function of adipose tissue and skeletal muscle. Proteoglycan decorin (DCN) regulates collagen fiber formation.
Alexes C. Daquinag, Zhanguo Gao, Cale Fussell, Kai Sun, Mikhail G. Kolonin   +4 more
doaj   +1 more source

Effect of Genetic Variation in a Drosophila Model of Diabetes-Associated Misfolded Human Proinsulin [PDF]

Genetics 196 (2014) 557-567, 2013
The identification and validation of gene-gene interactions is a major challenge in human studies. Here, we explore an approach for studying epistasis in humans using a Drosophila melanogaster model of neonatal diabetes mellitus. Expression of mutant preproinsulin, hINSC96Y, in the eye imaginal disc mimics the human disease activating conserved cell ...
arxiv   +1 more source