Results 111 to 120 of about 88,369 (330)

Editorial: Molecules of the extracellular matrix as cancer targets

Frontiers in Oncology, 2022
Nikos K. Karamanos, Martin Götte, Alberto Passi   +2 more
doaj   +1 more source

Potential Opportunities for Pharmacogenetic-Based Therapeutic Exploitation of Xanthine Dehydrogenase in Cardiovascular Disease

Antioxidants
The majority of naturally occurring mutations of the human gene XDH, are associated with reduced or completely absent xanthine oxidoreductase (XOR) activity, leading to a disease known as classical xanthinuria, which is due to the accumulation and ...
Gianmichele Massimo, Nicki Dyson, Fisayo Olotu, Rayomand S. Khambata, Amrita Ahluwalia   +4 more
doaj   +1 more source

Evaluation of the efficacy and safety of injectable glycosaminoglycan-peptide complex (GPC) in patients with osteoarthritis: a multicenter observational study GLADIOLUS (GPC in the treatment of osteoarthritis: a follow-up study of pain relief and local symptom reduction)

, 2020
Л. И. Алексеева, А. Е. Каратеев, E. Yu. Pogozheva, V. N. Amirdzanova, Е. С. Филатова, V. А. Nesterenko   +5 more
openalex   +2 more sources

A tumor-associated heparan sulfate-related glycosaminoglycan promotes the generation of functional regulatory T cells [PDF]

, 2023
Leticia Martín‐Cruz, Marcos Viñuela, Ioanna Kalograiaki, Alba Angelina, Paola Oquist-Phillips, Irene Real-Arévalo, F. Javier Cañada, José Ignacio Tudela, Luis Moltó, Jesús Moreno Sierra, José Luis Subiza, Óscar Palomares   +11 more
openalex   +1 more source

Synovial Fluid‐derived Micrococcus Luteus G18 Exacerbates Osteoarthritis Progression by Promoting Chondrocyte Degradation via TLR2/JNK/AP‐1 Signaling Pathway

Advanced Science, EarlyView.
Traditionally considered sterile, the articular cavity is now recognized to harbor microbial communities influencing osteoarthritis (OA). Integrating 16S rRNA sequencing and culturomics, Micrococcus luteus is enriched in advanced OA. Notably, M. luteus G18 exacerbates cartilage degeneration via TLR2/JNK/AP‐1‐mediated ECM disruption, revealing intra ...
Tingtao Chen, Qingwei Zeng, Tangchang Xu, Xinyue Qi, Kaiyi Li, Jing Wei, Liang Hao   +6 more
wiley   +1 more source

Lysosomal storage diseases as a complex pathophysiological and clinical problem - part one

Quality in Sport
Lysosomal storage diseases (LSDs) are a group of rare genetic diseases that are characterized by the accumulation of undecomposed molecules in lysosomes due to deficits in specific enzymes.
Karolina Mikołajczak
doaj   +1 more source

Modulating Integrin and Growth Factor Signaling With Peptides: Strategies to Synergistically Enhance Bone Tissue Regeneration

Advanced Science, EarlyView.
It has been demonstrated that, in the bone extracellular matrix (ECM), integrins and growth factor receptors (GFRs) engage in synergistic signaling to guide bone healing and regeneration. This review provides a comprehensive overview of current strategies using ECM‐derived peptides to recreate the cellular microenvironment and harness synergistic ...
Lluís Oliver‐Cervelló, Elisabetta Ada Cavalcanti‐Adam, Carlos Mas‐Moruno   +2 more
wiley   +1 more source

Observations on the acid glycosaminoglycan (mucopolysaccharide) content of the matrix of aging cartilage. [PDF]

, 1965
R. A. Stockwell, J. E. Scott
openalex   +1 more source

T1ρ-Mapping for Musculoskeletal Pain Diagnosis: Case Series of Variation of Water Bound Glycosaminoglycans Quantification before and after Fascial Manipulation® in Subjects with Elbow Pain [PDF]

, 2020
Rajiv Menon, S. Oswald, Preeti Raghavan, Ravinder R. Regatte, Antonio Stecco   +4 more
openalex   +1 more source

AIEgen‐Based Proactive Early Warning System and Precise Treatment Strategy for Monkeypox Prevention and Control

Advanced Science, EarlyView.
An intelligent early warning and treatment system for monkeypox, utilizing a sprayable AIEgen‐ liquid dressing (AIE@LD) that responds to lesion pH. Integrated with a smartphone app and cloud platform, it enables real‐time infection detection via fluorescence imaging and triggers on‐demand photodynamic therapy under white light, effectively eradicating ...
Wei Wang, Zining Liu, Mengjun Li, Judun Zheng, Ruilin Zhang, Ke Liu, Xiaoxue Li, Shaoying Wen, Jingze Yu, Meijia Pan, Fengbo Ma, Kun Zhou, Zheng Zhao, Chenguang Shen, Yuhui Liao   +14 more
wiley   +1 more source