Results 91 to 100 of about 64,705 (285)

Glycosaminoglycans in nerve injury .1. Low doses of glycosaminoglycans promote neurite formation

, 1996
This study has shown that glycosaminoglycans added to the culture medium may affect neurite formation in SH-SY5Y neuroblastoma cells, The most effective glycosaminoglycans are heparin and COS 8, a preparation with low anticoagulant activity, Promotion of
G. Prino, L. Vergani, E. Lesma, A. Di Giulio, A. Gorio, L. Ferro   +5 more
core   +1 more source

Wearable E‐Textiles for Cardiovascular Monitoring: Materials, Devices, and Integrated Systems

Advanced Science, EarlyView.
The graphical abstract highlights the role of conductive materials and textile fabrication techniques in enabling smart textiles for cardiovascular applications. It showcases textile‐based ECG monitoring, pulse sensing, hemodynamic monitoring, and cardiovascular tissue engineering, while emphasizing the challenges and design considerations that govern ...
Bangul Khan, Mahmoud Tavakoli, Norbert Radacsi, Bee Luan KHOO   +3 more
wiley   +1 more source

Neonatal Sevoflurane Exposure Induces Long‐Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2

Advanced Science, EarlyView.
Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang, Jiachen Wang, Taozhi Wang, Yanling Li, Youyi Zhao, Guanghui Hao, Peiqin Gong, Ruling Chen, Yilin Fang, Shengxi Wu, Haopeng Zhang, Hui Zhang   +11 more
wiley   +1 more source

Concentration of glycosaminoglycans in control vs osteoarthritis groups and control vs treatment groups.

, 2020
Concentration of glycosaminoglycans in control vs osteoarthritis groups and control vs treatment groups.
Edela Puricelli (81218), Deise Ponzoni (8714178), Carlos Eduardo Baraldi (8714172), Alexandre Silva Quevedo (8714175), Felipe Ernesto Artuzi (8714169)   +4 more
core   +1 more source

Single‐Nucleus Transcriptomic Atlas of Human Vellus Hair Pilosebaceous Units Reveals Age‐Associated Remodeling

Advanced Science, EarlyView.
Human vellus pilosebaceous units (PSUs) remain uncharted. This single‐nucleus atlas reveals coordinated remodeling of the aging PSU niche: reduced bulge stem cell representation with altered regenerative programs, increased representation of a stress‐responsive channel+ epithelial state, enhanced androgen‐responsive sebaceous programs, reduced ...
Ya'nan Li, Zhuoqiong Qiu, Xiaoyu Pan, Geyang Xu, Shanshan Peng, Ronghui Zhu, Qiuyang Luo, Xiaokai Fang, Xu Yao, Wei Li   +9 more
wiley   +1 more source

Aglycone Ebselen and β‑d‑Xyloside Primed Glycosaminoglycans Co-contribute to Ebselen β‑d‑Xyloside-Induced Cytotoxicity

, 2018
Most β-d-xylosides with hydrophobic aglycones are nontoxic primers for glycosaminoglycan assembly in animal cells. However, when Ebselen was conjugated to d-xylose, d-glucose, d-galactose, and d-lactose (8A–D), only Ebselen β-d-xyloside (8A) showed ...
Siqi Zhang (1397044), De Agostini, Ariane, Zhang, Siqi, Yang Tang (152970), Tao Jiang, Dacheng Fan, Ariane De Agostini (5048570), Tao Jiang (28401), Zhang, Lijuan, Dacheng Fan (1407652), Lijuan Zhang (36878), Siqi Zhang, Yang Tang, Yajing Chang, Fan, Dacheng, Tang, Yang, Lijuan Zhang, Jiang, Tao, Ariane De Agostini, Yajing Chang (1504330), Chang, Yajing, Zhang L, Jiang T, Zhang S, Agostini A, Tang Y, Fan D, Chang Y   +27 more
core   +2 more sources

The Effect of Glycosaminoglycans (GAGs) on Amyloid Aggregation and Toxicity

Molecules, 2015
Amyloidosis is a protein folding disorder in which normally soluble proteins are deposited extracellularly as insoluble fibrils, impairing tissue structure and function.
Clara Iannuzzi, Gaetano Irace, Ivana Sirangelo   +2 more
doaj   +1 more source

An Infusible Decellularized Extracellular Matrix Material Binds to Vasculature in Infarcted Myocardium and Induces Pro‐Reparative Gene Expression Following Acute Myocardial Infarction Through Inherent Avidity and Bioactive Signaling

Advanced Science, EarlyView.
To better characterize an infusible extracellular matrix (iECM) material, we applied size‐based fractionation to separate out components into two major fractions. We characterized these fractions to understand how material properties such as composition, morphology, and biochemical properties affect bioactive effects in the context of acute myocardial ...
Michael B. Nguyen, Alexander Chen, Quincy Lyons, Van K. Ninh, Maxwell C. McCabe, Colin Luo, Benjamin D. Bridgelal, Connor Uhre, Julian Cheng, Kate E. Reimold, Selena Cao, Kirk C. Hansen, Kevin R. King, Karen L. Christman   +13 more
wiley   +1 more source

Electrophoresis separation of glycosaminoglycans on nitrocellulose membranes

, 1996
A rapid and simple electrophoretic separation method on nitrocellulose membranes by a single run of glycosaminoglycans, mainly slow-moving and fast-moving heparins, dermatan sulfate, and chondroitin sulfate, is reported.
VOLPI, Nicola
core   +1 more source

BRCA1 Mutation‐Recognizing Tetrahedral Framework Nucleic Acid Nanoplatform Enables Coordinated PARP/WEE1 Inhibition and STING‐Associated Antitumor Immunity in Ovarian Cancer

Advanced Science, EarlyView.
BRCA1 mutation‐responsive FBOA‐tFNA selectively recognizes mutant transcripts and coordinates reduction‐responsive intracellular delivery of olaparib and adavosertib, amplifying DNA damage and weakening G2/M checkpoint protection. These effects are accompanied by STING‐associated immune activation and stronger antitumor immunity, while sequential anti ...
Chenyi Wang, Mengying Yao, Jinhui Xie, Dingjie Wang, Yashi Shi, Xiaodan Mao, Chunhua Lu, Pengming Sun   +7 more
wiley   +1 more source