Results 101 to 110 of about 64,705 (285)

Molecular MRI Reveals Macrophage‐Enriched Peritumoral Immune Remodeling After Incomplete Ablation in Liver Cancer

Advanced Science, EarlyView.
Incomplete microwave ablation (iMWA) induced a spatially organized, macrophage‐rich immunosuppressive tumor microenvironment (TME) in orthotopic VX2 liver tumors. Molecular MRI enhanced with europium‐doped very small superparamagnetic iron oxide nanoparticles (Eu‐VSOP) noninvasively visualized this remodeling, showing preferential nanoparticle ...
Yubei He, Han Xu, Julian M. M. Rogasch, Nikolaus Berndt, Jing Guo, Eyk Schellenberger, Akvile Häckel, Luisa Heidemann, Friederike Hesse, Yu Liu, Justus Ramtke, Nicola Beindorff, Frank Hofheinz, Avan Kader, Michael Mülleder, Kathrin Textoris‐Taube, Bernd Hamm, Dominik N. Müller, Robin Schmidt, Ralf Hauptmann, Heike Traub, Mathias Schannor, Lynn Jeanette Savic   +22 more
wiley   +1 more source

The Effect of Heparin and Other Exogenous Glycosaminoglycans (GAGs) in Reducing IL-1β-Induced Pro-Inflammatory Cytokine IL-8 and IL-6 mRNA Expression and the Potential Role for Reducing Inflammation

Pharmaceuticals
Glycosaminoglycans (GAGs) are long linear polysaccharides found in every mammalian tissue. Previously thought only to be involved in cellular structure or hydration, GAGs are now known to be involved in cell signaling and protein modulation in cellular ...
Murtaza Jafri, Lin Li, Binhua Liang, Ma Luo   +3 more
doaj   +1 more source

CD34+ Progenitors Promote Ageing‐Associated Valve Sclerosis through the PDGFR–JNK–JUNB Pathway

Advanced Science, EarlyView.
In age‐related aortic valve sclerosis, non‐bone marrow CD34+ progenitor valvular interstitial cells (VICs) undergo transdifferentiation into periostin+ myofibroblast‐like VICs via the PDGFR‐JNK‐JUNB axis, driving leaflet thickening and fibrosis. Ablating non‐bone marrow CD34+ cells attenuates this remodeling.
Xiaoping Yang, Hong Wu, Guoqiang Ren, Yuesheng Zhang, Zuoshi Wen, Pengwei Zhu, Zhangquan Ying, Liujun Jiang, Tingting Tao, Bohuan Zhang, Linwen Zhu, Han Wang, Han Zhang, Qingbo Xu, Jun Cheng, Honghua Ye   +15 more
wiley   +1 more source

Potential Opportunities for Pharmacogenetic-Based Therapeutic Exploitation of Xanthine Dehydrogenase in Cardiovascular Disease

Antioxidants
The majority of naturally occurring mutations of the human gene XDH, are associated with reduced or completely absent xanthine oxidoreductase (XOR) activity, leading to a disease known as classical xanthinuria, which is due to the accumulation and ...
Gianmichele Massimo, Nicki Dyson, Fisayo Olotu, Rayomand S. Khambata, Amrita Ahluwalia   +4 more
doaj   +1 more source

A Citrulline‐Functionalized Patch Coordinates Macrophage NRF2 Signaling and Arginine Metabolism for Tendon‐to‐Bone Repair

Advanced Science, EarlyView.
A locally implanted patch combines citrulline‐functionalized carbon dots, a thioketal‐containing membrane coating from tendon‐derived stem cells, and aligned core–shell fibers. In macrophages, the patch reduces inflammatory markers and enhances antioxidant signaling through nuclear factor erythroid 2‐related factor 2 (NRF2); in rats and rabbits, it ...
Yuhao Yu, Wencai Liu, Xinyue Yang, Hanzhe Zhang, Hui Xu, Xin Wang, Weimin Lin, Xiping Jiang, Chenrui Yuan, Yifei Wang, Weilin Yu, Yamin Li, Wei Song, Yaohua He   +13 more
wiley   +1 more source

Structure and Metabolism of Glycosaminoglycans

, 1990
in New Trends in Haemostasis: Coagulation Proteins, Endothelium, and Tissue Factors, Springer Verlag Publishers, Heidelberg, G. Schettler, L. Heene, J. Harenberg (Eds.), pp.
Loganathan, D., D. Loganathan, Linhardt, Robert J., Al-Hakim, A., R. J. Linhardt, A. Al-Hakim, Ampofo, S., S. A. Ampofo   +7 more
core   +1 more source

Microenvironment‐Responsive Biomimetic Hydrogels Delivering Cistanche Deserticola‐Derived Nanovesicles for Intervertebral Disc Degeneration

Advanced Science, EarlyView.
An injectable, microenvironment‐responsive hydrogel (HAPOCS@CDNVs) is developed for sustained delivery of Cistanche deserticola‐derived nanovesicles (CDNVs). By scavenging ROS, restoring mitochondrial function, and attenuating SASP, this platform effectively suppresses nucleus pulposus cell senescence and facilitates extracellular matrix reconstruction,
Ning Xu, Xiaoyu Cai, Xiaofu Tang, Weidong Liang, Linsong Teng, Yudong Jing, Haifeng Hu, Yuhao Duan, Mingjie Kuang, Lei Zhang, Shijie Han, Weibin Sheng   +11 more
wiley   +1 more source

High urinary excretion of glycosaminoglycans: a possible marker of glomerular involvement in diabetes.

, 1989
Many insulin-dependent diabetic patients with albuminuria in the "not at risk range" for diabetic nephropathy present high urinary excretion rates of glycosaminoglycans.
Baggio B., Cicerello E, Lavagnini T, Mastrosimone S, Gambaro G   +4 more
core   +1 more source

Ligand‐Ratio–Tuned DNA Nanocarriers Overcome Bladder Barriers for Ultralow‐Dose Intravesical Therapy

Advanced Science, EarlyView.
A programmable DNA framework drug carrier coordinates barrier transport, tumor targeting, and drug delivery through ligand‐ratio engineering. Systematic exploration of the Sgc8/fluorocarbon design space reveals a nonlinear optimal balance between penetration and cellular engagement, translating multifunctional integration into durable bladder tumor ...
Dunfang Liu, Xiao Chen, Hongliang Bao, Qian Xia, Gang Huang, Yang Yang   +5 more
wiley   +1 more source

Roles of Interstitial Albumin in the Subcutaneous Delivery of Therapeutic Peptides

Advanced Science, EarlyView.
A biomimetic extracellular matrix hydrogel platform reveals how interstitial albumin regulates peptide pharmacokinetics after subcutaneous administration. Albumin not only binds peptides but also shows a unique affinity for glycosaminoglycans, thereby reshaping peptide distribution and diffusion.
David Juriga, Anton Norberg, Esther Olaniran Håkansson, Jeroen W. van den Heuvel, Johan Gråsjö, Luke R. Odell, Anna Orlova, Per Hansson   +7 more
wiley   +1 more source