Horizontal gene transfer contributed to the evolution of extracellular surface structures [PDF]
, 2012 The single-cell layered ectoderm of the fresh water polyp Hydra fulfills the function of an epidermis by protecting the animals from the surrounding medium.
Altstätter, Johannes +13 more
core +1 more source
Hybrid bioprinting of chondrogenically induced human mesenchymal stem cell spheroids [PDF]
, 2020 To date, the treatment of articular cartilage lesions remains challenging. A promising strategy for the development of new regenerative therapies is hybrid bioprinting, combining the principles of developmental biology, biomaterial science, and 3D ...
Asadian, Mahtab +8 more
core +2 more sources
JIMD Reports, 2020 Purpose Current newborn screening (NBS) for mucopolysaccharidosis type I (MPSI) has very high false positive rates and low positive predictive values (PPVs).
Thomas J. Langan +9 more
doaj +1 more source
Lytic and mechanical stability of clots composed of fibrin and blood vessel wall components. [PDF]
, 2013 Background Proteases expressed in atherosclerotic plaque lesions generate collagen fragments, release glycosaminoglycans (chondroitin sulfate [CS] and dermatan sulfate [DS]) and expose extracellular matrix (ECM) proteins (e.g.
Bóta, Attila +7 more
core +1 more source
Mechanistic insights into molecular evolution of species-specific differential glycosaminoglycan binding surfaces in growth-related oncogene chemokines [PDF]
Royal Society Open Science, 2017 Chemokines are chemotactic cytokines involved in leucocyte trafficking to infected tissue. Growth-related oncogene (GRO) chemokines namely CXCL1, CXCL2 and CXCL3 are neutrophil activating chemokines sharing a conserved three-dimensional structure, but ...
Khushboo Gulati +2 more
doaj +1 more source
Age-related functional changes of total thyroid hormones and glycosaminoglycans in growing calves [PDF]
Veterinary World, 2020 Background and Aim: During the physiological growing, thyroid and proteoglycan glycosaminoglycan (GAG) changes dynamically occur, according to genetic and non-genetic factors.
Pietro Medica +3 more
doaj +1 more source
Effect of Genetic Variation in a Drosophila Model of Diabetes-Associated Misfolded Human Proinsulin [PDF]
Genetics 196 (2014) 557-567, 2013 The identification and validation of gene-gene interactions is a major challenge in human studies. Here, we explore an approach for studying epistasis in humans using a Drosophila melanogaster model of neonatal diabetes mellitus. Expression of mutant preproinsulin, hINSC96Y, in the eye imaginal disc mimics the human disease activating conserved cell ...
arxiv +1 more source
Glycosaminoglycans: From Vascular Physiology to Tissue Engineering Applications
Frontiers in Chemistry, 2021 Cardiovascular diseases represent the number one cause of death globally, with atherosclerosis a major contributor. Despite the clinical need for functional arterial substitutes, success has been limited to arterial replacements of large-caliber vessels (
Antonio Junior Lepedda +5 more
doaj +1 more source
Impact of exercise on articular cartilage in people at risk of, or with established, knee osteoarthritis: a systematic review of randomised controlled trials [PDF]
, 2018 This project is supported by a European Union Seventh Framework Programme (FP7-PEOPLE-2013-ITN; KNEEMO) under grant agreement number 607510.Peer ...
Bricca, Alessio +4 more
core +2 more sources
Influence of combined nitrate and fluoride intoxication on connective tissue disorders in rats gastric mucosa [PDF]
Archives of the Balkan Medical Union, 2019 Introduction. Certain regions in Europe and Ukraine have high concentration of fluorides in drinking waters. Highly developed agriculture can result in increased concentration of nitrates in ground and drinking waters. Therefore, their combined excessive
Oleh Y. AKIMOV +2 more
doaj +1 more source