Results 51 to 60 of about 60,454 (182)

Natural Presentation of Glycosaminoglycans in Synthetic Matrices for 3D Angiogenesis Models

Frontiers in Cell and Developmental Biology, 2021
Glycosaminoglycans (GAGs) are long, linear polysaccharides that occur in the extracellular matrix of higher organisms and are either covalently attached to protein cores, as proteoglycans or in free form.
Cornelia Zapp, Cornelia Zapp, Patricia Mundinger, Patricia Mundinger, Heike Boehm, Heike Boehm   +5 more
doaj   +1 more source

Sulfated Glycoaminoglycans and Proteoglycan Syndecan-4 Are Involved in Membrane Fixation of LL-37 and Its Pro-Migratory Effect in Breast Cancer Cells

Biomolecules, 2019
Initially characterized by its antimicrobial activities, LL-37 has also been shown to significantly contribute to tumor development. On breast cancer cell lines, LL-37 increases intracellular calcium via the TRPV2 channel and their migration via the ...
Chahrazed Habes, Günther Weber, Caroline Goupille   +2 more
doaj   +1 more source

Norfloxacin-Loaded Electrospun Scaffolds: Montmorillonite Nanocomposite vs. Free Drug

Pharmaceutics, 2020
Infections in nonhealing wounds remain one of the major challenges. Recently, nanomedicine approach seems a valid option to overcome the antibiotic resistance mechanisms.
Angela Faccendini, Marco Ruggeri, Dalila Miele, Silvia Rossi, Maria Cristina Bonferoni, Carola Aguzzi, Pietro Grisoli, Cesar Viseras, Barbara Vigani, Giuseppina Sandri, Franca Ferrari   +10 more
doaj   +1 more source

Chemokine‐Capturing Wound Contact Layer Rescues Dermal Healing

Advanced Science, 2021
Excessive inflammation often impedes the healing of chronic wounds. Scavenging of chemokines by multiarmed poly(ethylene glycol)‐glycosaminoglycan (starPEG‐GAG) hydrogels has recently been shown to support regeneration in a diabetic mouse chronic skin ...
Lucas Schirmer, Passant Atallah, Uwe Freudenberg, Carsten Werner   +3 more
doaj   +1 more source

Is Endothelial Nitric Oxide Synthase a Moonlighting Protein Whose Day Job is Cholesterol Sulfate Synthesis? Implications for Cholesterol Transport, Diabetes and Cardiovascular Disease

Entropy, 2012
Theoretical inferences, based on biophysical, biochemical, and biosemiotic considerations, are related here to the pathogenesis of cardiovascular disease, diabetes, and other degenerative conditions.
Stephanie Seneff, Ann Lauritzen, Robert Davidson, Laurie Lentz-Marino   +3 more
doaj   +1 more source

Mechanistic insights into molecular evolution of species-specific differential glycosaminoglycan binding surfaces in growth-related oncogene chemokines [PDF]

Royal Society Open Science, 2017
Chemokines are chemotactic cytokines involved in leucocyte trafficking to infected tissue. Growth-related oncogene (GRO) chemokines namely CXCL1, CXCL2 and CXCL3 are neutrophil activating chemokines sharing a conserved three-dimensional structure, but ...
Khushboo Gulati, Minal Jamsandekar, Krishna Mohan Poluri   +2 more
doaj   +1 more source

Glycosaminoglycans and urine flow rate.

, 1989
The value of glycosaminoglycans determination in urine has been challenged because the relation between the glycosaminoglycans concentration and other signs of kidney damage is a matter of controversy. It is quite possible that the observed discrepancies
Hotz P, Pilliod J, Boillat MA
core   +1 more source

ROLE OF GLYCOSAMINOGLYCANS IN DIABETIC NEPHROPATHY [PDF]

, 1992
A number of abnormalities of glycosaminoglycan metabolism have been reported in diabetes mellitus. These include anomalous synthesis, catabolism and sulphation.
Baggio B., Gambaro G., GAMBARO G, BAGGIO, BRUNO   +3 more
core   +1 more source

Influence of combined nitrate and fluoride intoxication on connective tissue disorders in rats gastric mucosa [PDF]

Archives of the Balkan Medical Union, 2019
Introduction. Certain regions in Europe and Ukraine have high concentration of fluorides in drinking waters. Highly developed agriculture can result in increased concentration of nitrates in ground and drinking waters. Therefore, their combined excessive
Oleh Y. AKIMOV, Arthur V. MISCHENKO, Vitalii O. KOSTENKO   +2 more
doaj   +1 more source

Regional Variation in Androgen Receptor Expression and Biomechanical Properties May Contribute to Cryptorchidism Susceptibility in the LE/orl Rat

Frontiers in Endocrinology, 2018
Background: The process of testicular descent requires androgen and insulin-like 3, hormones secreted by fetal Leydig cells. Knowledge concerning distinct and common functions of these hormones in regulating development of the fetal gubernaculum remains ...
Joshua T. Morgan, Alan K. Robbins, Abigail B. Mateson, Kazuki Sawamoto, Shunji Tomatsu, Dione R. Gray, Jason P. Gleghorn, Julia Spencer Barthold   +7 more
doaj   +1 more source