Results 91 to 100 of about 39,910 (236)
Anomeric Inversions by Glycosidases [PDF]
Nature, 1955 β-AMYLASE has so far been considered a unique case among hydrolytic enzymes, as its action is accompanied by an inversion of the anomeric configuration of the splitting product produced; that is, β-maltose is formed from amylose, contrary to expectation.
openaire +2 more sources
The FEBS Journal, EarlyView.Investigated mutations in transthyretin (TTR) disrupt the F87‐centered hydrophobic core that stabilizes its tetrameric structure. The mild I107V mutation weakens inter‐chain packing, while H88R fully abolishes tetramer formation, yielding a monomeric, aggregation‐prone form. Structural, biophysical, and computational analyses reveal that both mutations
István L. Bódy +7 more
wiley +1 more source
Discovery of a cryptic aminoacidic triad involved in the temperature adaptation of GH1 enzymes
The FEBS Journal, EarlyView.Cold‐active enzymes retain high catalytic activity at low temperatures but are characterized by thermal instability, a behavior not fully understood. Comparison between a cold‐active GH1 and its mesophilic counterparts highlights the role of a three‐residue motif (W‐M‐F) in conferring structural stability to a mesophilic GH1.
Stefania Digiovanni +5 more
wiley +1 more source
CLONING OF THE 1.4-kb mRNA SPECIES OF HUMAN COMPLEMENT FACTOR H REVEALS A NOVEL MEMBER OF THE SHORT CONSENSUS REPEAT FAMILY RELATED TO THE CARBOXY TERMINAL OF THE CLASSICAL 150-kDa MOLECULE [PDF]
, 1991 Three factor H mRNA species of 4.3 kb, 1.8 kb, and 1.4 kb are constitutively expressed in human liver. Having previously characterized full-length cDNA clones derived from the 4.3-kb and 1.8-kb factor mRNA, we report here the isolation and eucaryotic ...
Dierich, Manfred P. +4 more
core +2 more sources
Plant, Cell &Environment, EarlyView.ABSTRACT Plants can perceive specific elicitors in the oral secretions (OS) of herbivorous insects and respond by increasing their defences. Whether plants can discriminate among similar herbivorous insect species and differentially modulate their defence responses against them is largely unknown.
Wenfeng Ye +4 more
wiley +1 more source
Enterohemorrhagic Escherichia coli with particular attention to the German outbreak strain O104:H4 [PDF]
, 2012 This review deals with the epidemiology and ecology of enterohemorrhagic Escherichia coli (EHEC), a subset of the verocytotoxigenic Escherichia coli (VTEC), and subsequently discusses its public health concern.
De Reu, K +4 more
core +1 more source
Diels-alder cycloaddition in the synthesis of 1-azafagomine, analogs, and derivatives as glycosidase inhibitors [PDF]
, 2012 This comprehensive review deals with the synthesis of 1-azafagomine, analogs, and derivatives having the Diels-Alder cycloaddition as the key step. Most of the compounds referred are racemic or have been resolved by lipase transesterification.
Alves, M. José +3 more
core +1 more source
Plant Biology, EarlyView.Pre‐treatment of grapevine plants with oregano essential oil vapour alleviates downy mildew susceptibility by accumulation of monoterpenol glycosides. Abstract Grapevine downy mildew, caused by the oomycete Plasmopara viticola, is a destructive disease that causes major economic losses as most elite grapevine cultivars are susceptible to this pathogen.
J. R. P. E. Mars +6 more
wiley +1 more source
Whole genome sequencing for mutation discovery in a single case of lysosomal storage disease (MPS type 1) in the dog. [PDF]
, 2020 Mucopolysaccharidosis (MPS) is a metabolic storage disorder caused by the deficiency of any lysosomal enzyme required for the breakdown of glycosaminoglycans.
Aguilar, Miriam +13 more
core +3 more sources
Synthesis and biological analysis of novel glycoside derivatives of L-AEP, as targeted antibacterial agents [PDF]
, 2016 To develop targeted methods for treating bacterial infections, the feasibility of using glycoside derivatives of the antibacterial compound L-R-aminoethylphosphonic acid (L-AEP) has been investigated.
Bovill, Richard +3 more
core +1 more source