Functional divergence in the role of N-linked glycosylation in smoothened signaling [PDF]
, 2015 The G protein-coupled receptor (GPCR) Smoothened (Smo) is the requisite signal transducer of the evolutionarily conserved Hedgehog (Hh) pathway. Although aspects of Smo signaling are conserved from Drosophila to vertebrates, significant differences have ...
A Helenius +83 more
core +3 more sources
Angewandte Chemie, EarlyView.The cupula is a membrane within the vestibular organ that senses rotatory accelerations of the head. Metabolic glycoengineering in combination with bioorthogonal labeling demonstrates that in adult zebrafish – being a model for the human inner ear – this membrane is constantly renewed.
Hans Scherer +4 more
wiley +2 more sources
Proteomic analysis of the excretory-secretory products from larval stages of Ascaris suum reveals high abundance of glycosyl hydrolases [PDF]
, 2013 Background: Ascaris lumbricoides and Ascaris suum are socioeconomically important and widespread parasites of humans and pigs, respectively. The excretory-secretory (ES) molecules produced and presented at the parasite-host interface during the different
Deforce, Dieter +7 more
core +5 more sources
The inhibition profile of sesamol against α-glycosidase and acetylcholinesterase enzymes
International Journal of Food Properties, 2019 Sesamol (1,3-benzodioxol-5-ol) is found in the oilseed product, sesame. In our study, the inhibitory effects of sesamol compound on acetylcholinesterase and α-glycosidase enzymes were evaluated.
Meryem Topal
doaj +1 more source
Novel pyrrolizidine alkaloid [PDF]
, 1991 The present invention involves a purified bioactive compound of the formula: ##STR1## wherein at least one of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are H or an acyl having less than about five carbon atoms.
Elbein, Alan D., Tropea, Joseph E.
core +1 more source
1,6-Cyclophellitol Cyclosulfates : A New Class of Irreversible Glycosidase Inhibitor [PDF]
, 2017 The essential biological roles played by glycosidases, coupled to the diverse therapeutic benefits of pharmacologically targeting these enzymes, provide considerable motivation for the development of new inhibitor classes.
Aerts, Johannes M.F.G. +12 more
core +9 more sources
Carbohydrate-Modified Electrode Surfaces Sensitive to ß-Glucosidase Enzyme Activity
International Journal of Electrochemical Science, 2014 A surface modification which renders a carbon electrode sensitive to β-glucosidase enzyme activity is reported. 2-Nitro-4-(4-diazophenoxymethyl)-phenyl β-D-glucopyranoside was prepared in four steps from the known starting material 2-nitro-4-benzyloxy 2 ...
Emily M. Ervin +5 more
doaj +1 more source
Molecular Docking Analysis of Embelia ribes for Selected Constituents as Spodoptera frugiperda (Fall Armyworm) Beta Glycosidase and Caspase-1 Inhibitors [PDF]
Nature Environment and Pollution Technology, 2023 Insect pest control is one of the major issues facing the agriculture sector because of the need for new agrochemicals and biocontrol agents that are environmentally friendly, economically affordable, and safe for human health.
Srinivasan Kumaraswamy, Vasantha-Srinivasan Prabhakaran and Radhakrishnan Narayanaswamy
doaj +1 more source
Conformationally-Locked C-Glycosides: Tuning Aglycone Interactions for Optimal Cheperone Behaviour in Gaucher Fibroblasts [PDF]
, 2016 A series of conformationally locked C-glycosides based on the 3-aminopyrano[3,2-b]pyrrol-2(1H)-one (APP) scaffold has been synthesized. The key step involved a totally stereocontrolled C-Michael addition of a serine-equivalent C-nucleophile to tri-O ...
Avenoza, A. +9 more
core +1 more source
Immune response of amebiasis and immune evasion by Entamoeba histolytica
Frontiers in Immunology, 2016 Entamoeba histolytica is a protozoan parasite and the causative agent of amebiasis. It is estimated approximately 1% of humans are infected with E. histolytica, resulting in an estimate of 100,000 deaths annually.
Kumiko eNakada-Tsukui +2 more
doaj +1 more source