Results 51 to 60 of about 32,114 (276)

Identification of Allobaculum mucolyticum as a novel human intestinal mucin degrader

Gut Microbes, 2021
The human gut microbiota plays a central role in intestinal health and disease. Yet, many of its bacterial constituents are functionally still largely unexplored.
Guus H. van Muijlwijk, Guido van Mierlo, Pascal W.T.C. Jansen, Michiel Vermeulen, Nancy M.C. Bleumink-Pluym, Noah W. Palm, Jos P.M. van Putten, Marcel R. de Zoete   +7 more
doaj   +1 more source

Neonatal Sevoflurane Exposure Induces Long‐Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2

Advanced Science, EarlyView.
Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang, Jiachen Wang, Taozhi Wang, Yanling Li, Youyi Zhao, Guanghui Hao, Peiqin Gong, Ruling Chen, Yilin Fang, Shengxi Wu, Haopeng Zhang, Hui Zhang   +11 more
wiley   +1 more source

All Eight Stereoisomeric d-Glyconic-δ-lactams:  Synthesis, Conformational Analysis, and Evaluation as Glycosidase Inhibitors

, 2016
An efficient and general synthetic route to all eight stereoisomeric d-glycono-δ-lactams has been developed. The strategy involves, as a key step, a stereodivergent δ-lactam formation with configurational retention or inversion at C-4 of a starting γ ...
Hayamitsu Adachi (1666837), Takahiko Satoh (2995797), Hikaru Nakamura (2312473), Eiki Shitara (3025071), Yoshio Nishimura (1965370), Tomio Takeuchi (2995788), Fukiko Kojima (1965376)   +6 more
core   +3 more sources

Semi‐Artificial Photosynthesis Enables Light‐Driven Biomanufacturing in Non‐Photosynthetic Bacteria

Advanced Science, EarlyView.
A non‐invasive strategy exploits endogenous H2S metabolism in B. subtilis to drive in situ CdS biomineralization, enabling tight bio‐abiotic contact without genetic modification. Light harvested by the biomineralized nanoparticles powers NADPH regeneration, elevating 2’‐fucosyllactose and surfactin titres two‐ to three‐fold.
Jie Zheng, Anqi Tong, Wenxin Li, Meng Qiao, Yang Gu, Muhammad Sohail, Shan He, Sheng Yang, Xing Zhang   +8 more
wiley   +1 more source

Novel Hyperthermophilic Crenarchaeon Thermofilum adornatum sp. nov. Uses GH1, GH3, and Two Novel Glycosidases for Cellulose Hydrolysis

Frontiers in Microbiology, 2020
A novel hyperthermophilic, anaerobic filamentous archaeon, Thermofilum adornatum strain 1910bT, is capable of growing with cellulose as its sole carbon and energy source. This strain was isolated from a terrestrial hot spring in Kamchatka, Russia.
Kseniya S. Zayulina, Tatiana V. Kochetkova, Ulyana E. Piunova, Ulyana E. Piunova, Rustam H. Ziganshin, Olga A. Podosokorskaya, Ilya V. Kublanov   +6 more
doaj   +1 more source

A photoresponsive glycosidase mimic

Chemical Communications, 2014
Azobenzene-3,3'-dicarboxylic acid exists in photoisomerizable (E) and (Z)-forms. Deprotonation of the carboxylic acid groups from the (E)-form occurs simultaneously, whereas in the (Z)-form it occurs in a stepwise fashion. The mono anionic form of the (Z)-isomer acts as a glycosidase mimic that proceeds through a general acid-general base catalytic ...
Mousumi, Samanta, V, Siva Rama Krishna, Subhajit, Bandyopadhyay   +2 more
openaire   +3 more sources

Impact of selected oenological yeasts on chemical profile and colour development in smoke-exposed red wine

OENO One
The increasing prevalence of wildfire smoke in vineyards presents a challenge for red wine production due to smoke-derived volatile phenols (VPs) and their glycosylated precursors.
Daniel Zieff, Maret Du Toit, Rémi Schneider, Benoit Divol   +3 more
doaj   +1 more source

Synthesis of Glycosides by Glycosynthases

Molecules, 2017
The many advances in glycoscience have more and more brought to light the crucial role of glycosides and glycoconjugates in biological processes. Their major influence on the functionality and stability of peptides, cell recognition, health and immunity ...
Marc R. Hayes, Jörg Pietruszka
doaj   +1 more source

Water Caltrop (Trapa quadrispinosa Roxb.) Husk Improves Oxidative Stress and Postprandial Blood Glucose in Diabetes: Phenolic Profiles, Antioxidant Activities and α-Glycosidase Inhibition of Different Fractions with In Vitro and In Silico Analyses

Antioxidants, 2022
The aim of this study was to investigate the phenolic profiles, antioxidant activities and α-glycosidase inhibitory activities of three different phenolic fractions from water caltrop (Trapa quadrispinosa Roxb.) husk and to further explore the ...
Yuanyue Zhang, Shengbao Cai, Shuang Ma, Shuai Zhao, Junjie Yi, Linyan Zhou   +5 more
doaj   +1 more source

Modulation of Animal Gut Health by Milk Oligosaccharide

Animal Research and One Health, EarlyView.
This review summarizes the composition and structural characteristics of MOs across different mammalian species, and elucidates their roles and mechanisms in maintaining intestinal homeostasis by regulating gut microbiome and enhancing intestinal chemical, physical and immune barriers.
Ningtao Chen, Nana Jing, Shiyu Tao, Mingyue Fei, Wentao Lv, Hua Yang, Yingping Xiao, Haiqin Wu   +7 more
wiley   +1 more source