Targeting Regulation of Macrophage to Treat Metabolic Disease: Role of Phytochemicals
Cell Proliferation, EarlyView.One‐third of the world's population is affected by metabolic syndrome. Complicated pathogenesis and limited drugs cause the growing prevalence of metabolic syndrome. Macrophage‐mediated metaflammation is closely associated with the development of metabolic syndrome. The role of phytochemicals targeting macrophages in the treatment of metabolic syndrome
Zeting Ye +6 more
wiley +1 more source
How homogeneous are the trehalose, maltose and sucrose water solutions ? An Insight from Molecular Dynamics simulations [PDF]
arXiv, 2005 The structural properties resulting from the reciprocal influence between water and three well-known homologous disaccharides, namely trehalose, maltose and sucrose, in aqueous solutions have been investigated in the 4-66 wt % concentration range by means of molecular dynamics computer simulations. Hydration numbers clearly show that trehalose binds to
arxiv
Acarbose impairs gut Bacteroides growth by targeting intracellular glucosidases
mBioAcarbose is a type 2 diabetes medicine that prevents dietary starch breakdown into glucose by inhibiting host amylase and glucosidase enzymes. Numerous gut species in the Bacteroides genus enzymatically break down starch and change in relative abundance ...
Haley A. Brown +6 more
doaj +1 more source
Hydration of vinyl ether groups by unsaturated glycoside hydrolases and their role in bacterial pathogenesis [PDF]
, 2008 Many pathogenic microorganisms invade mammalian and/or plant cells by producing polysaccharide-degrading enzymes (lyases and hydrolases). Mammalian glycosaminoglycans and plant pectins that form part of the cell surface matrix are typical targets for ...
Bunzo Mikami +4 more
core +2 more sources
Biotechnology for Biofuels, 2016 BackgroundThermophilic enzymes have attracted much attention for their advantages of high reaction velocity, exceptional thermostability, and decreased risk of contamination.
Xiaowei Peng +3 more
semanticscholar +1 more source
Amylolytic glycoside hydrolases [PDF]
Cellular and Molecular Life Sciences, 2016 Štefan Janeček, Birte Svensson
openaire +3 more sources
Deficiency of Aging‐Related Gene Chitinase‐Like 4 Impairs Olfactory Epithelium Homeostasis
Cell Proliferation, EarlyView.Deficiency of Chil4 impairs OE homeostasis through loss of sustentacular cells and a specific type of immature sensory neuron, cell cycle arrest in globose basal cells, and inflammatory activation in microglia‐like cells. ABSTRACT Mammalian olfactory epithelium (OE) undergoes consistent self‐renewal throughout life.
Tingting Wu +7 more
wiley +1 more source
The molecular structure of the glycoside hydrolase domain of Cwp19 from Clostridium difficile
The FEBS Journal, 2017 Clostridium difficile is a burden to healthcare systems around the world, causing tens of thousands of deaths annually. The S‐layer of the bacterium, a layer of protein found of the surface of cells, has received a significant amount of attention over ...
William J. Bradshaw +4 more
semanticscholar +1 more source
N‐acetylglucosamine sensing in the filamentous soil fungus Trichoderma reesei
The FEBS Journal, EarlyView.N‐acetylglucosamine (GlcNAc) is involved in diverse signaling pathways in dimorphic yeasts and bacteria, including virulence and cell death. Here, we investigated GlcNAc sensing in Trichoderma reesei. GlcNAc signaling influences around 2100 genes in this filamentous soil fungus.
Sadia Fida Ullah +6 more
wiley +1 more source
Hierarchical hydropathic evolution of influenza glycoproteins (N2, H3, A/H3N2) under relentless vaccination pressure [PDF]
arXiv, 2013 Hemagglutinin (HA) and neuraminidase (NA) are highly variable envelope glycoproteins. Here hydropathic analysis, previously applied to quantify common flu (H1N1) evolution (1934-), is applied to the evolution of less common but more virulent (avian derived) H3N2 (1968-), beginning with N2.
arxiv