Results 171 to 180 of about 10,037 (210)
Mechanism‐Based Inhibitors to Probe Transitional States of Glycoside Hydrolases
, 2006 Recent structural and kinetic studies indicate that glycosidases (glycoside hydrolases) change the peripheral structure of their catalytic sites dynamically to trim glycan structures. Inhibitors that label specific amino acid residues in the active site of these enzymes based on its mechanism of action are powerful tools to probe such a hidden ...
Hiroshi Hinou +2 more
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Journal of the American Chemical Society, 2017 The design of covalent inhibitors in glycoscience research is important for the development of chemical biology probes. Here we report the synthesis of a new carbocyclic mechanism-based covalent inhibitor of an α-glucosidase. The enzyme efficiently catalyzes its alkylation via either an allylic cation or a cationic transition state.
Saeideh Shamsi Kazem Abadi +5 more
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Biotechnology Advances, 2018 Glycoside hydrolase family 20 β-N-acetyl-d-hexosaminidases (GH20s) catalyze the hydrolysis of glycosidic linkages in glycans, glycoproteins and glycolipids. The diverse substrates of GH20s account for their various roles in many important bioprocesses, such as glycoprotein modification, glycoconjugate metabolism, gamete recognition and chitin ...
Tian Liu, Yanwei Duan, Qing Yang
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The Synthesis of a New Class of Potential Inhibitors for Glycoside Hydrolases†
Journal of Carbohydrate Chemistry, 2005 Some attempts toward the synthesis of novel inhibitors of glycosyl transferases are described. More successfully, the synthesis of an activated cyclopropacyclohexene and an amide and an amine of a cyclopropa‐fused pyranose are described. None of these three novel compounds proved to be a significant inhibitor of a retaining α‐glucosidase from barley. †
Robert V. Stick, Keith A. Stubbs
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ChemInform, 1995 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
J. Lehmann, Beatrice Rob
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ChemInform, 1997 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Wayne M. Best +4 more
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Treatment of Diabetes mellitus with the Glycoside Hydrolase Inhibitor Acarbose (BAYg 5421)
, 2015 K. Sch�ffling +2 more
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