Results 71 to 80 of about 162,319 (334)

High resolution crystal structure of the Endo-N-acetyl-beta-D-glucosaminidase responsible for the deglycosylation of hypocrea jecorina cellulases [PDF]

, 2012
Endo-N-acetyl-beta-D-glucosaminidases (ENGases) hydrolyze the glycosidic linkage between the two N-acetylglucosamine units that make up the chitobiose core of N-glycans. The endo-N-acetyl-beta-D-glucosaminidases classified into glycoside hydrolase family
Anita Van Landschoot, Bart Devreese, Ingeborg Stals, Mats Sandgren, Michael Ward, Renwick Dobson, Saeid Karkehabadi, Steve Kim   +7 more
core   +4 more sources

Diffusion-based Molecule Generation with Informative Prior Bridges [PDF]

arXiv, 2022
AI-based molecule generation provides a promising approach to a large area of biomedical sciences and engineering, such as antibody design, hydrolase engineering, or vaccine development. Because the molecules are governed by physical laws, a key challenge is to incorporate prior information into the training procedure to generate high-quality and ...
arxiv  

A nucleobase-centered coarse-grained representation for structure prediction of RNA motifs [PDF]

Nucleic Acids Res. 46, 1674 (2018), 2017
We introduce the SPlit-and-conQueR (SPQR) model, a coarse-grained representation of RNA designed for structure prediction and refinement. In our approach, the representation of a nucleotide consists of a point particle for the phosphate group and an anisotropic particle for the nucleoside.
arxiv   +1 more source

Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation [PDF]

, 2020
The exopolysaccharide galactosaminogalactan (GAG) is an important virulence factor of the fungal pathogen Aspergillus fumigatus. Deletion of a gene encoding a putative deacetylase, Agd3, leads to defects in GAG deacetylation, biofilm formation, and ...
A Ghafoor, A Morin, AB Boraston, AW Blake, C Bundalovic-Torma, C Guerrero, C Ryder, C Steentoft, C Vuong, CM Payne, Collaborative Computational Project Number 4., CS Cummins, DC Sheppard, DE Blair, DE Blair, DJ Little, DJ Little, DJ Little, E Andrés, E Potterton, EN Kitova, F Le Mauff, F Sievers, FN Gravelat, FN Gravelat, GB Whitfield, GD Brown, GM Sheldrick, GM Sheldrick, H Aragunde, H Ashkenazy, H Ostapska, H Takada, H Zakariassen, J Hoßbach, J Sun, JA Jorge, JA Jorge, JJ Distler, JJ Tesmer, JL Reissig, JW Jensen, K Miyazawa, K Mizutani, KM Colvin, LA Kelley, LK Jennings, LS Marmont, M Gonzalez, M Oda, M Strong, MD Winn, MJ Lee, MJ Lee, MM Shaik, N Nwe, NA Baker, NC Bamford, NC Bamford, P Emsley, P Ruperez, P Vasseur, PC Bardalaye, PD Adams, PD Adams, RC Edgar, RE Lewis, S Jana, S Kaur, S Kumar, SC Potter, SF Altschul, T Fontaine, T Inoue, V Pokrovskaya, VE Fadouloglou, VK Köseoğlu, W Vollmer, W Wang, X Wang, X-L Li, Y Araki, Y Itoh, Y Kidani, Y Kidani   +84 more
core   +3 more sources

Discovery of a Kojibiose Hydrolase by Analysis of Specificity-Determining Correlated Positions in Glycoside Hydrolase Family 65

Molecules, 2021
The Glycoside Hydrolase Family 65 (GH65) is an enzyme family of inverting α-glucoside phosphorylases and hydrolases that currently contains 10 characterized enzyme specificities. However, its sequence diversity has never been studied in detail.
Emma De Beul, Alana Jongbloet, Jorick Franceus, Tom Desmet   +3 more
doaj   +1 more source

Purification of glycoside hydrolases from Bacteroides fragilis [PDF]

Applied and Environmental Microbiology, 1980
Six glycoside hydrolases in the culture medium of Bacteroides fragilis--alpha-glucosidase, beta-glucosidase, alpha-galactosidase, beta-galactosidase, beta-N-acetylglucosaminidase, and alpha-L-fucosidase-were systematically purified by ammonium sulfate precipitation, gel filtration chromatography, and density gradient isoelectric focusing.
J O Berg, L Lindqvist, C E Nord
openaire   +3 more sources

Hydration of vinyl ether groups by unsaturated glycoside hydrolases and their role in bacterial pathogenesis [PDF]

, 2008
Many pathogenic microorganisms invade mammalian and/or plant cells by producing polysaccharide-degrading enzymes (lyases and hydrolases). Mammalian glycosaminoglycans and plant pectins that form part of the cell surface matrix are typical targets for ...
Bunzo Mikami, Kousaku Murata, Takafumi Itoh, Wataru Hashimoto, Yukie Maruyama   +4 more
core   +2 more sources

The structure of a resuscitation-promoting factor domain from Mycobacterium tuberculosis shows homology to lysozymes [PDF]

, 2005
Resuscitation-promoting factor (RPF) proteins reactivate stationary-phase cultures of (G+C)-rich Gram-positive bacteria including the causative agent of tuberculosis, Mycobacterium tuberculosis.
AT Brunger, BA Johnson, Brian Henderson, Christian Roumestand, Claire Bagnéris, D Sharma, EJ van Asselt, EJ van Asselt, G Cornilescu, GV Mukamolova, GV Mukamolova, GV Mukamolova, H Song, JB Raymond, JG Lees, JL Pons, JM Tufariello, John Ward, JP Linge, L Holm, M Cohen-Gonsaud, M Cohen-Gonsaud, M Hartmann, Martin Cohen-Gonsaud, Nicholas H Keep, Philippe Barthe, R Koradi, RA Laskowski   +27 more
core   +2 more sources

Micro‐ and Nano‐Bots for Infection Control

Advanced Materials, EarlyView.
This review presents a strategic vision for integrating micro‐ and nanobots in the pipeline for infection diagnosis, prevention, and treatment. To develop these robots as a practical solution for infection management, their design principles are clarified based on their propulsion mechanisms and then categorized infection management domains based on ...
Azin Rashidy Ahmady, Shadman Khan, Hong Han, Wei Gao, Zeinab Hosseinidoust, Tohid F. Didar   +5 more
wiley   +1 more source

Draft Genome Sequences of Salmonella enterica Serovar Typhimurium LT2 with Deleted Chitinases That Are Emerging Virulence Factors. [PDF]

, 2017
Chitinases are glycosyl hydrolases that catalyze the hydrolysis of the β-1,4 linkages in complex carbohydrates and those that contain GlcNAc. These enzymes are considered emerging virulence factors during infection because the host glycan changes.
Arabyan, Narine, Huang, Bihua C, Weimer, Bart C   +2 more
core   +1 more source