Results 191 to 200 of about 31,833 (220)

Glycosphingolipids and Insulin Resistance

2011
Glycosphingolipids are structural membrane components, residing largely in the plasma membrane with their sugar-moieties exposed at the cell's surface. In recent times a crucial role for glycosphingolipids in insulin resistance has been proposed. A chronic state of insulin resistance is a rapidly increasing disease condition in Western and developing ...
Aerts, J.M., Boot, R.G., van Eijk, M., Groener, J., Bijl, N., Lombardo, E., Bietrix, F.M., Dekker, N., Groen, A.K., Ottenhof, M., Roomen, C., Aten, J., Serlie, M., Langeveld, M., Wennekes, T., Overkleeft, H.S.   +15 more
openaire   +4 more sources

Glycosphingolipids and insulin resistance

Progress in Lipid Research, 2009
Obesity is associated with an increased risk for insulin resistance, a state characterized by impaired responsiveness of liver, muscle and adipose tissue to insulin. One class of lipids involved in the development of insulin resistance are the (glyco)sphingolipids. Ceramide, the most simple sphingolipid, directly inhibits phosphorylation of the insulin
Mirjam, Langeveld, Johannes M F G, Aerts
openaire   +2 more sources

Soluble Adamantyl Glycosphingolipid Analogs as Probes of Glycosphingolipid Function

2006
Despite the extensive structural characterization of glycosphingolipids (GSLs), their functions in cell physiology and pathobiology remain elusive. This is largely owing to the fact that they are difficult to handle, being insoluble in aqueous media, and that no one gene alone determines their synthesis. The heterogeneity of the lipid moiety provides a
Clifford, Lingwood, Skanda, Sadacharan, Maan, Abul-Milh, Murugespillai, Mylvaganum, Marcus, Peter   +4 more
openaire   +2 more sources

Glycosphingolipids and cell death

Glycoconjugate Journal, 2003
Sphingolipids have been implicated in various cellular processes including growth, cell-cell or ligand-receptor interactions, and differentiation. In addition to their importance as reservoirs of metabolites with important signaling properties, sphingolipids also help provide structural order to plasma membrane lipids and proteins within the bilayer ...
Meryem, Bektas, Sarah, Spiegel
openaire   +2 more sources

Glycosphingolipids as toxin receptors

Seminars in Cell & Developmental Biology, 2004
A number of proteins produced by certain bacteria and plants are potently toxic to mammalian cells. This toxicity results from their ability to catalytically modify macromolecules that are required for essential cellular functions such as vesicular trafficking, cytoskeletal assembly, signalling or protein synthesis.
Daniel C, Smith, J Michael, Lord, Lynne M, Roberts, Ludger, Johannes   +3 more
openaire   +2 more sources

Topology of glycosphingolipid degradation

Trends in Cell Biology, 1996
Glycosphingolipids (GSLs) form cell-type-specific patterns on the surface of eukaryotic cells. Degradation of plasma-membrane-derived GSLs in the lysosomes after internalization through the endocytic pathway is achieved through the concerted actions of hydrolysing enzymes and sphingolipid activator proteins.
K, Sandhoff, T, Kolter
openaire   +2 more sources

Lysosomal Glycosphingolipid Storage Diseases

Annual Review of Biochemistry, 2019
Glycosphingolipids are cell-type-specific components of the outer leaflet of mammalian plasma membranes. Gangliosides, sialic acid–containing glycosphingolipids, are especially enriched on neuronal surfaces. As amphi-philic molecules, they comprise a hydrophilic oligosaccharide chain attached to a hydrophobic membrane anchor, ceramide.
Bernadette, Breiden, Konrad, Sandhoff
openaire   +2 more sources

Molecular arrangements in glycosphingolipids

Chemistry and Physics of Lipids, 1972
Abstract A number of homogeneous glycosphingolipids have been prepared and their structural behaviour studied in the solid state as well as in lipid-water systems and in surface films. Mainly X-ray diffraction techniques have been used in the phase analyses. A very complex phase pattern is usually found — e.g.
Sixten Abrahamsson, Irmin Pascher, Kåre Larsson, Karl-Anders Karlsson   +3 more
openaire   +2 more sources

Glycosphingolipids of human plasma

Archives of Biochemistry and Biophysics, 1985
A number of glycosphingolipids, including 10 gangliosides, not previously identified in human plasma have been characterized. The plasma contains 2 micrograms of lipid-bound sialic acid/ml plasma and 54% of the gangliosides are monosialo, 30% disialo, 10% trisialo, and 6% tetrasialo.
S K, Kundu, I, Diego, S, Osovitz, D M, Marcus   +3 more
openaire   +2 more sources

Glycosphingolipids and Kidney Disease

2011
Glycosphingolipids, derived from the addition of sugar-moieties to the sphingolipid ceramide, are highly abundant in the kidney. Glycosphingolipids are known to play an important role in organ function at least in part from inherited lipid storage diseases such as Anderson-Fabry disease (Fabry's disease; FD) that results from a mutation in alpha ...
Andrew R, Mather, Leah J, Siskind
openaire   +2 more sources