Results 111 to 120 of about 18,580 (229)

Myelin Impairment and Regeneration in the Central Nervous System: Molecular Mechanisms, Diseases, and Prospective Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
Proper myelin formation is crucial for normal neural circuit function, while myelin deficiency can lead to neural circuit dysfunction and cognitive decline, notably in Alzheimer's disease and other central nervous system demyelinating disorders. This review summarizes central myelin's structure and function, demyelination biomarkers and pathological ...
Lihong Huang, Peng Cheng, Guangdong Liu, Yang Xiang, Zhen Hong, Weidong Le   +5 more
wiley   +1 more source

Human gastric glycosphingolipids recognized by Helicobacter pylori vacuolating cytotoxin VacA

, 2007
Many bacterial toxins utilize cell surface glycoconjugate receptors for attachment to target cells. In the present study the potential carbohydrate binding of Helicobacter pylori vacuolating cytotoxin VacA was investigated by binding to human gastric ...
Barone, Silvia, Roche, Niamh,, Ångström, Jonas,, Teneberg, Susann,, Ilver, Dag,, Telford, John L   +5 more
core   +1 more source

Exploration into Galectin-3 Driven Endocytosis and Lattices

Biomolecules
Essentially all plasma membrane proteins are glycosylated, and their activity is regulated by tuning their cell surface dynamics. This is achieved by glycan-binding proteins of the galectin family that either retain glycoproteins within lattices or drive
Massiullah Shafaq-Zadah, Estelle Dransart, Satish Kailasam Mani, Julio Lopes Sampaio, Lydia Bouidghaghen, Ulf J. Nilsson, Hakon Leffler, Ludger Johannes   +7 more
doaj   +1 more source

Insights into the modulation of age‐related macular degeneration: Molecular and systems‐level perspectives

Acta Ophthalmologica, Volume 104, Issue S293, Page S4-S35, October 2026.
ENGLISH SUMMARY In developed countries, age‐related macular degeneration (AMD) is the leading cause of visual impairment in the aging population. Understanding of its pathogenesis is limited and the number of patients is predicted to continue rising. AMD is classified into two main forms: dry and neovascular AMD (dAMD and nAMD, respectively).
Hanna Heloterä
wiley   +1 more source

Protein O‐Glycosylation Shapes Lymphatic Endothelia and Lymph Node Macrophage Populations

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
To study the functional roles of O‐glycans on lymphatic endothelia, we deleted Cosmc, the chaperone required for core‐1 O‐glycan synthesis. Loss of core‐1 O‐glycans entailed major changes in glycoprotein composition of lymphatic endothelial cells (LEC), including reduced podoplanin (Pdpn), CD44, and Lyve‐1, and increased ICAM‐1; reduced CD44 was caused
Jasmin Frey, Annkathrin Ratter, Finn Brigger, Louie Cielen, Pascal Kunz, Ea Tulin, Kinga Mikos, Lothar Dieterich, Marco D'Addio, Cornelia Halin, Richard D. Cummings, Vivianne I. Otto   +11 more
wiley   +1 more source

Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential

Angewandte Chemie International Edition, Volume 65, Issue 39, 21 September 2026.
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

Glycosphingolipids in Cardiovascular Disease: Insights from Molecular Mechanisms and Heart Failure Models

Biomolecules
This review explores the crucial role of glycosphingolipids (GSLs) in the context of cardiovascular diseases (CVDs), focusing on their biosynthesis, metabolic pathways, and implications for clinical outcomes.
Sarah Huang, Karima Abutaleb, Sumita Mishra   +2 more
doaj   +1 more source

High resolution proton NMR spectra of blood-group active glycosphingolipids in DMSO-d6

, 1980
It has been shown recently that the application of high resolution proton magnetic resonance spectroscopy is a useful technique for the structural elucidation of glycosphingolipids.
Dabrowski, J., J. DABROWSKI, HANFLAND, P., P. HANFLAND, H. EGGE, KUHN, S., EGGE , H., S. KUHN   +7 more
core   +1 more source

A new aspect in glycolipid biology: glycosphingolipids as antigens recognized by T lymphocytes.

, 2002
T cells may recognize a large variety of ligands with different chemical structures. Recently, glycosphingolipids have also been shown to stimulate human T lymphocytes.
Shamshiev A, Manolova V, Mori L, Mazorra Z, De Libero G, Gober HJ, Donda A   +6 more
core   +1 more source

The Bacterium P. aeruginosa Disperses Ordered Membrane Domains by Targeting Phase Boundaries

Biomolecules
Various pathogens use receptors on the host’s plasma membrane for their cellular uptake. For the bacterium Pseudomonas aeruginosa, interactions between its lectin LecA and the host cell glycosphingolipid globotriaosylceramide (also known as Gb3) are ...
Kai Stober, Fabian Schwerdtfeger, Sahaja Aigal, Yves Mely, Winfried Römer   +4 more
doaj   +1 more source