Results 91 to 100 of about 18,580 (229)

Structural and functional glycosphingolipidomics by glycoblotting with aminooxy-functionalized gold nanoparticle [PDF]

, 2008
Glycosphingolipids (GSLs) synthesized in Golgi apparatus by sequential transfer of sugar residues to a ceramide lipid anchor are ubiquitously distributing on vertebrate plasma membranes.
Midori Abe, Noriko Nagahori, Shin-Ichiro Nishimura   +2 more
core  

Myriocin slows the progression of established atherosclerotic lesions in apolipoprotein E gene knockout mices⃞

Journal of Lipid Research, 2008
The serine palmitoyl transferase inhibitor myriocin potently suppresses the development of atherosclerosis in apolipoprotein E (apoE) gene knockout (apoE−/−) mice fed a high-fat diet.
Elias N. Glaros, Woojin S. Kim, Carmel M. Quinn, Wendy Jessup, Kerry-Anne Rye, Brett Garner   +5 more
doaj   +1 more source

Encoding Cell‐Surface Receptor Function Through Glycosylation: Lessons From CD44

ChemBioChem, Volume 27, Issue 19, 14 October 2026.
CD44 function is not solely determined by its protein sequence, it is dynamically encoded by its glycosylation state. Glycan remodeling generates distinct functional receptor states that regulate ligand recognition, receptor organization, lectin interactions, and signaling.
María Payá‐García, José Manuel Rojas‐Marcos, Iris A. Bermejo, Diego Del Balzo, Ana Ardá, Luca Unione, Jesús Jiménez‐Barbero, Ana Gimeno   +7 more
wiley   +1 more source

Functional role of gangliosides in cell membranes: from physiology to pathogenesis

Acta Biomedica Scientifica
Gangliosides are complex glycosphingolipids that constitute essential components of cell membranes and actively participate in the regulation of numerous biological processes.
E. M. Ustinov, I. A. Andrievskaya
doaj   +1 more source

Structural Insights into Escherichia coli Shiga Toxin (Stx) Glycosphingolipid Receptors of Porcine Renal Epithelial Cells and Inhibition of Stx-Mediated Cellular Injury Using Neoglycolipid-Spiked Glycovesicles

Microorganisms, 2019
Shiga toxin (Stx) producing Escherichia coli (STEC) cause the edema disease in pigs by releasing the swine-pathogenic Stx2e subtype as the key virulence factor.
Johanna Detzner, Caroline Gloerfeld, Gottfried Pohlentz, Nadine Legros, Hans-Ulrich Humpf, Alexander Mellmann, Helge Karch, Johannes Müthing   +7 more
doaj   +1 more source

Lysosomal multi-omics reveals altered sphingolipid catabolism associated with lysosomal dysfunction in the aging brain

Cell Reports
Summary: Lipids dynamically reside in multiple intracellular locations, and their organellar distribution is important for function. During brain aging, lysosomal lipid changes have been noted, but lipid identity, interactions, and functional relevance ...
Chinmoy Sarkar, Yi Chen, Dexter PH. Nguyen, Mehari M. Weldemariam, Yulemni Morel, Amir Mehrabani-Tabari, Nikki Gorny, Olivia Pettyjohn-Robin, Nivedita Hegdekar, Sagarina Thapa, Sazia Arefin Kachi, Sabrina Bustos, Stephanie Zalesak-Kravec, Christina Williams, Nicholas Leahy, Renee Ti Chou, Shilpa D. Kumar, Carrie McCracken, Thomas A. Blanpied, Mariusz Karbowski, Jace W. Jones, Maureen A. Kane, Michael P. Cummings, Marta M. Lipinski   +23 more
doaj   +1 more source

Biosynthesis and metabolic degradation of sphingolipids not containing sialic acid

Journal of Lipid Research, 1972
Interest in sphingolipid metabolism has increased rapidly during the past decade, and many of the steps involved in the biosynthesis and metabolic degradation of sphingolipids are now known. In this review these studies are critically exmined.
Pierre Morell, Peter Braun
doaj   +1 more source

Binding of V. cholerae El Tor to mixtures of glycosphingolipids.

, 2013
(A) Chemical detection by anisaldehyde. (B) Autoradiograms obtained by binding of V. cholerae JBK 70. The lanes were: Lane 1, non-acid glycosphingolipids of human small intestine, 20 µg; Lane 2, non-acid glycosphingolipids of dog erythrocytes, 20 µg ...
Sara Lindén (83552), Omid Teymournejad (275590), John Benktander (204852), Jonas Ångström (204855), Susann Teneberg (204862), Hasse Karlsson (124258), Michael Lebens (275591)   +6 more
core   +1 more source

Glycosphingolipid Disorders of the Brain

, 2008
Glycosphingolipids, comprising a ceramide lipid backbone linked to one/more saccharides, are particularly abundant on the outer leaflet of the eukaryotic plasma membrane and play a role in a wide variety of essential cellular processes. Biosynthesis and subsequently degradation of these lipids is tightly regulated via the involvement of numerous ...
Boomkamp, S, Butters, T
openaire   +2 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, Volume 600, Issue 19, Page 2961-2971, October 2026.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source