Results 71 to 80 of about 14,058 (187)
MITF Regulates CFTR Expression to Participate in Myocardial Ischemia–Reperfusion Injury
The Journal of Gene Medicine, Volume 28, Issue 8, August 2026.MITF regulates CFTR expression in MIRI, and disruption of the MITF‐CFTR axis is associated with aggravated injury in cellular and animal models. Restoring CFTR partially mitigates MITF deficiency‐related damage. These findings support the involvement of MITF‐CFTR regulation in MIRI and provide a basis for further mechanistic investigation.
Baoxin Tang +4 more
wiley +1 more source
Metabolic Regulation of Macrophages in Health and Disease
MedComm, Volume 7, Issue 8, August 2026.Extracellular metabolites drive metabolic rewiring of glucose, lipid, and amino acid pathways in macrophages, steering their polarization toward pro‐ or anti‐inflammatory phenotypes and shaping a wide range of disease processes. Macrophages from different tissues display distinct metabolic signatures, and therapeutic strategies that target these ...
Shan Huang +6 more
wiley +1 more source
Glycosphingolipid Disorders of the Brain
, 2008 Glycosphingolipids, comprising a ceramide lipid backbone linked to one/more saccharides, are particularly abundant on the outer leaflet of the eukaryotic plasma membrane and play a role in a wide variety of essential cellular processes. Biosynthesis and subsequently degradation of these lipids is tightly regulated via the involvement of numerous ...
Boomkamp, S, Butters, T
openaire +2 more sources
Structure and biological functions of fungal cerebrosides
Anais da Academia Brasileira de Ciências, 2004 Ceramide monohexosides (CMHs, cerebrosides) are glycosphingolipids composed of a hydrophobic ceramide linked to one sugar unit. In fungal cells, CMHs are very conserved molecules consisting of a ceramide moiety containing 9-methyl-4,8-sphingadienine in ...
Barreto-Bergter Eliana +2 more
doaj
Helicobacter pylori SabA binding gangliosides of human stomach
Virulence, 2018 Adhesion of Helicobacter pylori to the gastric mucosa is a prerequisite for the pathogenesis of H. pylori related diseases. In this study, we investigated the ganglioside composition of human stomach as the target for attachment mediated by H.
John Benktander +3 more
doaj +1 more source
Exploration into Galectin-3 Driven Endocytosis and Lattices
BiomoleculesEssentially all plasma membrane proteins are glycosylated, and their activity is regulated by tuning their cell surface dynamics. This is achieved by glycan-binding proteins of the galectin family that either retain glycoproteins within lattices or drive
Massiullah Shafaq-Zadah +7 more
doaj +1 more source
BiomoleculesThis review explores the crucial role of glycosphingolipids (GSLs) in the context of cardiovascular diseases (CVDs), focusing on their biosynthesis, metabolic pathways, and implications for clinical outcomes.
Sarah Huang +2 more
doaj +1 more source
The Bacterium P. aeruginosa Disperses Ordered Membrane Domains by Targeting Phase Boundaries
BiomoleculesVarious pathogens use receptors on the host’s plasma membrane for their cellular uptake. For the bacterium Pseudomonas aeruginosa, interactions between its lectin LecA and the host cell glycosphingolipid globotriaosylceramide (also known as Gb3) are ...
Kai Stober +4 more
doaj +1 more source
The good, the bad, and the unknown nature of decreased GD3 synthase expression
Frontiers in Molecular NeuroscienceThis paper explores the physiological consequences of decreased expression of GD3 synthase (GD3S), a biosynthetic enzyme that catalyzes the synthesis of b-series gangliosides.
Borna Puljko +13 more
doaj +1 more source
Journal of Lipid ResearchAtherosclerosis can be described as a local acquired lysosomal storage disorder (LSD), resulting from the build-up of undegraded material in lysosomes.
André R.A. Marques +21 more
doaj +1 more source