Results 61 to 70 of about 14,058 (187)
Lysosomal storage diseases and the heat shock response: convergences and therapeutic opportunities
Journal of Lipid Research, 2014 Lysosomes play a vital role in the maintenance of cellular homeostasis through the recycling of cell constituents, a key metabolic function which is highly dependent on the correct function of the lysosomal hydrolases and membrane proteins, as well as ...
Linda Ingemann, Thomas Kirkegaard
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International Journal of Cancer, Volume 159, Issue 4, Page 936-950, 15 August 2026.What's new? Colorectal cancer (CRC) is increasingly complicated by drug‐resistant tumors that limit the effectiveness of anticancer therapies. Because resistance mechanisms vary among patients and can evolve over time, personalized treatment strategies are needed.
Keren Zohar +16 more
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Journal of Lipid Research, 2008 The serine palmitoyl transferase inhibitor myriocin potently suppresses the development of atherosclerosis in apolipoprotein E (apoE) gene knockout (apoE−/−) mice fed a high-fat diet.
Elias N. Glaros +5 more
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Advanced NanoBiomed Research, Volume 6, Issue 8, August 2026.We developed an assay to distinguish cellular binding from internalization. Compatible with microscopy and high‐throughput screening, the method identifies ligand‐mediated uptake. Applying top candidates to a protein‐based DNA carrier enhanced transfection efficiency, providing a rational strategy to improve non‐viral gene delivery systems.
David Scherer +5 more
wiley +1 more source
, 2014 Citation: 'glycosphingolipid' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.G02662 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
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Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.Glucose, galactose, mannose and fructose can either fuel or fight tumours by rewiring metabolism and immunity. Their context‐dependent double‐edged nature suggests that precisely targeted monosaccharide interventions could become a new pillar of precision oncology.
Qin Ouyang, Ke Gao, Haojie Lu, Shu Zhang
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Functional role of gangliosides in cell membranes: from physiology to pathogenesis
Acta Biomedica ScientificaGangliosides are complex glycosphingolipids that constitute essential components of cell membranes and actively participate in the regulation of numerous biological processes.
E. M. Ustinov, I. A. Andrievskaya
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Microorganisms, 2019 Shiga toxin (Stx) producing Escherichia coli (STEC) cause the edema disease in pigs by releasing the swine-pathogenic Stx2e subtype as the key virulence factor.
Johanna Detzner +7 more
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Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.In cardiac cells, Plin5/AMPK regulate lipid homeostasis; excess CD36‐mediated uptake drives lipotoxicity, mitochondrial dysfunction, and CVDs (e.g., heart failure). Biomarkers (ApoB/ApoA‐1) and therapies (SGLT2 inhibitors) target this cascade. ABSTRACT Cardiac lipid metabolism is fundamental to myocardial energy homeostasis, with fatty acid oxidation ...
Peiyun Xie +3 more
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Biosynthesis and metabolic degradation of sphingolipids not containing sialic acid
Journal of Lipid Research, 1972 Interest in sphingolipid metabolism has increased rapidly during the past decade, and many of the steps involved in the biosynthesis and metabolic degradation of sphingolipids are now known. In this review these studies are critically exmined.
Pierre Morell, Peter Braun
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