Results 141 to 150 of about 36,633 (265)

Phosphorylation disrupts the interaction between the intrinsically disordered region of the oncogenic NDRG1 and lipid vesicles

Protein Science, Volume 35, Issue 3, March 2026.
Abstract NDRG1 is a multifunctional regulatory human protein implicated in crucial cellular processes and acting as a central hub of a cancer‐related interactome. In lung cancer, increased NDRG1 expression is associated with resistance to chemotherapy and is linked to the cellular response to nickel, a known tumor driver in air pollution.
Noemi Carosella, Chiara Pastorello, Jehan Waeytens, Ylenia Beniamino, Valentina Roncassaglia, Lucrezia Serra, Vincent Raussens, Elisabetta Mileo, Stefano Ciurli, Barbara Zambelli   +9 more
wiley   +1 more source

Helicobacter pylori SabA binding gangliosides of human stomach

Virulence, 2018
Adhesion of Helicobacter pylori to the gastric mucosa is a prerequisite for the pathogenesis of H. pylori related diseases. In this study, we investigated the ganglioside composition of human stomach as the target for attachment mediated by H.
John Benktander, Angela Barone, Miralda Madar Johansson, Susann Teneberg   +3 more
doaj   +1 more source

Beyond nocardioform: Transcriptionally active microbes and host responses in equine mucoid placentitis

Equine Veterinary Journal, Volume 58, Issue 2, Page 601-618, March 2026.
Abstract Background Nocardioform placentitis (NP) is an understudied form of equine placentitis historically attributed to nocardioform bacteria, yet it remains uncertain whether these organisms are the sole pathogens involved. Objectives To elucidate the pathophysiology of NP and the host–pathogen interaction. Study Design In vivo clinical multi‐omics
Machteld van Heule, Margo Verstraete, Jamie Kaj Norris, Kinga Barbara Graniczkowsa, Kirsten E. Scoggin, Hossam El‐Sheikh Ali, Barry A. Ball, Ward De Spiegelaere, Peter Daels, Bart C. Weimer, Pouya Dini   +10 more
wiley   +1 more source

Exploration into Galectin-3 Driven Endocytosis and Lattices

Biomolecules
Essentially all plasma membrane proteins are glycosylated, and their activity is regulated by tuning their cell surface dynamics. This is achieved by glycan-binding proteins of the galectin family that either retain glycoproteins within lattices or drive
Massiullah Shafaq-Zadah, Estelle Dransart, Satish Kailasam Mani, Julio Lopes Sampaio, Lydia Bouidghaghen, Ulf J. Nilsson, Hakon Leffler, Ludger Johannes   +7 more
doaj   +1 more source

α-Lactosylceramide Protects Against iNKT-Mediated Murine Airway Hyperreactivity and Liver Injury Through Competitive Inhibition of Cd1d Binding. [PDF]

, 2019
Invariant natural killer T (iNKT) cells, which are activated by T cell receptor (TCR)-dependent recognition of lipid-based antigens presented by the CD1d molecule, have been shown to participate in the pathogenesis of many diseases, including asthma and ...
Chang, Ya-Jen, Chi, Po-Yu, Gervay-Hague, Jacquelyn, Han, Yun-Chiann, Hsieh, Hsiao-Wu, Kao, Hsien-Neng, Lai, Alan Chuan-Ying, Thio, Christina Li-Ping   +7 more
core  

Glycosphingolipids in Cardiovascular Disease: Insights from Molecular Mechanisms and Heart Failure Models

Biomolecules
This review explores the crucial role of glycosphingolipids (GSLs) in the context of cardiovascular diseases (CVDs), focusing on their biosynthesis, metabolic pathways, and implications for clinical outcomes.
Sarah Huang, Karima Abutaleb, Sumita Mishra   +2 more
doaj   +1 more source

Non-equilibrium raft-like membrane domains under continuous recycling

, 2005
We present a model for the kinetics of spontaneous membrane domain (raft) assembly that includes the effect of membrane recycling ubiquitous in living cells.
A. Filippov, C. Dietrich, I. P. Sugar, L. A. Gheber, M. Seul, M. S. Turner, Matthew S. Turner, Nicholas D. Socci, P. G. Saffman, Pierre Sens, S. L. Veatch   +10 more
core   +1 more source

The Bacterium P. aeruginosa Disperses Ordered Membrane Domains by Targeting Phase Boundaries

Biomolecules
Various pathogens use receptors on the host’s plasma membrane for their cellular uptake. For the bacterium Pseudomonas aeruginosa, interactions between its lectin LecA and the host cell glycosphingolipid globotriaosylceramide (also known as Gb3) are ...
Kai Stober, Fabian Schwerdtfeger, Sahaja Aigal, Yves Mely, Winfried Römer   +4 more
doaj   +1 more source

The good, the bad, and the unknown nature of decreased GD3 synthase expression

Frontiers in Molecular Neuroscience
This paper explores the physiological consequences of decreased expression of GD3 synthase (GD3S), a biosynthetic enzyme that catalyzes the synthesis of b-series gangliosides.
Borna Puljko, Borna Puljko, Josip Grbavac, Vinka Potočki, Katarina Ilic, Barbara Viljetić, Svjetlana Kalanj-Bognar, Svjetlana Kalanj-Bognar, Marija Heffer, Željko Debeljak, Željko Debeljak, Senka Blažetić, Kristina Mlinac-Jerkovic, Kristina Mlinac-Jerkovic   +13 more
doaj   +1 more source

Glycosphingolipids are modulators of disease pathogenesis in amyotrophic lateral sclerosis

Proceedings of the National Academy of Sciences of the United States of America, 2015
James C. Dodge, Christopher M. Treleaven, J. Pacheco, Samantha Cooper, Channa Bao, Marissa Abraham, Mandy Cromwell, S. Sardi, W. Chuang, R. Sidman, Seng H. Cheng, L. Shihabuddin   +11 more
semanticscholar   +1 more source