Results 181 to 190 of about 18,580 (229)
Journal of Agricultural and Food Chemistry, 2023 Glycosphingolipids participate in brain development, intestinal tract maturation, and defense against gut pathogens. Here, we performed a qualitative and quantitative comparison of milk glycosphingolipids from secretors and nonsecretors.
Zhongfu Wang +2 more
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A General Chemoenzymatic Strategy for the Synthesis of Glycosphingolipids [PDF]
European Journal of Organic Chemistry, 2016 A concise, prototypical, and stereoselective strategy for the synthesis of therapeutically and immunologically significant glycosphingolipids has been developed.
Mohui Wei, Liuqing Wen, Kenneth Huang
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Glycosphingolipids and cell death
Glycoconjugate Journal, 2003Sphingolipids have been implicated in various cellular processes including growth, cell-cell or ligand-receptor interactions, and differentiation. In addition to their importance as reservoirs of metabolites with important signaling properties, sphingolipids also help provide structural order to plasma membrane lipids and proteins within the bilayer ...
Meryem, Bektas, Sarah, Spiegel
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HPLC of Glycosphingolipids and Phospholipids
2021This chapter reviews HPLC methodology developed for the analysis of the glycosphingolipids and phospholipids, which are ubiquitious components of biological membranes. The isolation and measurement of glycosphingolipids and phospholipids are essential for many studies on complex biological systems.
R H, McCluer +2 more
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Biochemistry of glycosphingolipid degradation
Clinica Chimica Acta, 1997Glycosphingolipids (GSLs) form cell-type-specific patterns on the surface of eukaryotic cells. Degradation of GSLs requires endocytotic membrane flow of plasma membrane-derived GSLs into the lysosomes as the digesting organelles. Recent research focused on the mechanisms leading to selective membrane degradation in the lysosomes and on the mechanism ...
K, Sandhoff, T, Kolter
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Glycosphingolipids and insulin resistance
Progress in Lipid Research, 2009Obesity is associated with an increased risk for insulin resistance, a state characterized by impaired responsiveness of liver, muscle and adipose tissue to insulin. One class of lipids involved in the development of insulin resistance are the (glyco)sphingolipids. Ceramide, the most simple sphingolipid, directly inhibits phosphorylation of the insulin
Mirjam, Langeveld, Johannes M F G, Aerts
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Soluble Adamantyl Glycosphingolipid Analogs as Probes of Glycosphingolipid Function
2006Despite the extensive structural characterization of glycosphingolipids (GSLs), their functions in cell physiology and pathobiology remain elusive. This is largely owing to the fact that they are difficult to handle, being insoluble in aqueous media, and that no one gene alone determines their synthesis. The heterogeneity of the lipid moiety provides a
Clifford, Lingwood +4 more
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Topology of glycosphingolipid degradation
Trends in Cell Biology, 1996Glycosphingolipids (GSLs) form cell-type-specific patterns on the surface of eukaryotic cells. Degradation of plasma-membrane-derived GSLs in the lysosomes after internalization through the endocytic pathway is achieved through the concerted actions of hydrolysing enzymes and sphingolipid activator proteins.
K, Sandhoff, T, Kolter
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Glycosphingolipids in membrane architecture
Journal of Supramolecular Structure, 1977AbstractAs part of a program to investigate the behavior and interactions of glycolipids in biological membranes we have synthesized spin‐labeled derivatives of 2 families of carbohydrate‐bearing ceramides (glycosphingolipids): simple neutral glycolipids and gangliosides.
F J, Sharom, C W, Grant
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Glycosphingolipids as toxin receptors
Seminars in Cell & Developmental Biology, 2004A number of proteins produced by certain bacteria and plants are potently toxic to mammalian cells. This toxicity results from their ability to catalytically modify macromolecules that are required for essential cellular functions such as vesicular trafficking, cytoskeletal assembly, signalling or protein synthesis.
Daniel C, Smith +3 more
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