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Advances in Experimental Medicine and Biology, 2021
Glycosphingolipids are amphiphilic plasma membrane components formed by a glycan linked to a specific lipid moiety. In this chapter we report on these compounds, on their role played in our cells to maintain the correct cell biology.In detail, we report on their structure, on their metabolic processes, on their interaction with proteins and from this ...
E. Chiricozzi +10 more
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Glycosphingolipids are amphiphilic plasma membrane components formed by a glycan linked to a specific lipid moiety. In this chapter we report on these compounds, on their role played in our cells to maintain the correct cell biology.In detail, we report on their structure, on their metabolic processes, on their interaction with proteins and from this ...
E. Chiricozzi +10 more
semanticscholar +3 more sources
Synthetic Strategies for Modified Glycosphingolipids and Their Design as Probes.
Chemical Reviews, 2018The plasma membrane of cells contains a diverse array of lipids that provide important structural and biological features. Glycolipids are typically a minor component of the cell membrane and consist primarily of glycosphingolipids (GSLs).
Carmanah D. Hunter +4 more
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Deep Profiling of Immunosuppressive Glycosphingolipids and Sphingomyelins in Wild Cordyceps.
Journal of Agricultural and Food Chemistry, 2018Deep profiling of glycosphingolipids and sphingomyelins in wild Cordyceps was carried out by using offline chromatographic enrichment followed by ultrahigh performance liquid chromatography-ultrahigh definition-quadrupole time-of-flight mass spectrometry
Jia-Ning Mi +6 more
semanticscholar +1 more source
Biochemistry of glycosphingolipid degradation
Clinica Chimica Acta, 1997Glycosphingolipids (GSLs) form cell-type-specific patterns on the surface of eukaryotic cells. Degradation of GSLs requires endocytotic membrane flow of plasma membrane-derived GSLs into the lysosomes as the digesting organelles. Recent research focused on the mechanisms leading to selective membrane degradation in the lysosomes and on the mechanism ...
K, Sandhoff, T, Kolter
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Glycosphingolipids govern gene expression
Glycoconjugate Journal, 2003To elucidate the biological significance of the lactosylceramide (LacCer) branching in glycosphingolipid (GSL) biosynthesis, we established ganglioside GM3- and lactosylsulfatide SM3-reconstituted cells by introducing the GM3 synthase gene and the sulfotransferase gene, respectively.
Jin-ichi, Inokuchi +3 more
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Glycosphingolipids in membrane architecture
Journal of Supramolecular Structure, 1977AbstractAs part of a program to investigate the behavior and interactions of glycolipids in biological membranes we have synthesized spin‐labeled derivatives of 2 families of carbohydrate‐bearing ceramides (glycosphingolipids): simple neutral glycolipids and gangliosides.
F J, Sharom, C W, Grant
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Glycosphingolipids and Insulin Resistance
2011Glycosphingolipids are structural membrane components, residing largely in the plasma membrane with their sugar-moieties exposed at the cell's surface. In recent times a crucial role for glycosphingolipids in insulin resistance has been proposed. A chronic state of insulin resistance is a rapidly increasing disease condition in Western and developing ...
Aerts, J.M. +15 more
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Glycosphingolipids and insulin resistance
Progress in Lipid Research, 2009Obesity is associated with an increased risk for insulin resistance, a state characterized by impaired responsiveness of liver, muscle and adipose tissue to insulin. One class of lipids involved in the development of insulin resistance are the (glyco)sphingolipids. Ceramide, the most simple sphingolipid, directly inhibits phosphorylation of the insulin
Mirjam, Langeveld, Johannes M F G, Aerts
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Soluble Adamantyl Glycosphingolipid Analogs as Probes of Glycosphingolipid Function
2006Despite the extensive structural characterization of glycosphingolipids (GSLs), their functions in cell physiology and pathobiology remain elusive. This is largely owing to the fact that they are difficult to handle, being insoluble in aqueous media, and that no one gene alone determines their synthesis. The heterogeneity of the lipid moiety provides a
Clifford, Lingwood +4 more
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Glycosphingolipids and cell death
Glycoconjugate Journal, 2003Sphingolipids have been implicated in various cellular processes including growth, cell-cell or ligand-receptor interactions, and differentiation. In addition to their importance as reservoirs of metabolites with important signaling properties, sphingolipids also help provide structural order to plasma membrane lipids and proteins within the bilayer ...
Meryem, Bektas, Sarah, Spiegel
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