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Topology of glycosphingolipid degradation
Trends in Cell Biology, 1996Glycosphingolipids (GSLs) form cell-type-specific patterns on the surface of eukaryotic cells. Degradation of plasma-membrane-derived GSLs in the lysosomes after internalization through the endocytic pathway is achieved through the concerted actions of hydrolysing enzymes and sphingolipid activator proteins.
K, Sandhoff, T, Kolter
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Lysosomal Glycosphingolipid Storage Diseases
Annual Review of Biochemistry, 2019Glycosphingolipids are cell-type-specific components of the outer leaflet of mammalian plasma membranes. Gangliosides, sialic acid–containing glycosphingolipids, are especially enriched on neuronal surfaces. As amphi-philic molecules, they comprise a hydrophilic oligosaccharide chain attached to a hydrophobic membrane anchor, ceramide.
Bernadette, Breiden, Konrad, Sandhoff
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Molecular arrangements in glycosphingolipids
Chemistry and Physics of Lipids, 1972Abstract A number of homogeneous glycosphingolipids have been prepared and their structural behaviour studied in the solid state as well as in lipid-water systems and in surface films. Mainly X-ray diffraction techniques have been used in the phase analyses. A very complex phase pattern is usually found — e.g.
Sixten Abrahamsson +3 more
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Glycosphingolipids of human plasma
Archives of Biochemistry and Biophysics, 1985A number of glycosphingolipids, including 10 gangliosides, not previously identified in human plasma have been characterized. The plasma contains 2 micrograms of lipid-bound sialic acid/ml plasma and 54% of the gangliosides are monosialo, 30% disialo, 10% trisialo, and 6% tetrasialo.
S K, Kundu +3 more
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Biochemistry, 1984
Natural and synthetic glycosphingolipids containing neutral sugars have been analyzed by positive and negative ion fast atom bombardment mass spectrometry. Basic structural characterization including saccharide size and sequence and ceramide composition is possible on the basis of the fragment ions observed.
M E, Hemling +3 more
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Natural and synthetic glycosphingolipids containing neutral sugars have been analyzed by positive and negative ion fast atom bombardment mass spectrometry. Basic structural characterization including saccharide size and sequence and ceramide composition is possible on the basis of the fragment ions observed.
M E, Hemling +3 more
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Supercritical fluid chromatography of glycosphingolipids
Analytical Biochemistry, 1988Glucose polymers and three classes of glycosphingolipids were permethylated and studied by supercritical fluid chromatography using a DB-5 coated capillary columns and carbon dioxide as the mobile phase. Column restrictors were fabricated at each column tip as described by E.J. Guthrie and H.E. Schwartz (1986, J. Chromatogr. Sci. 24, 236).
Kuei, J. +2 more
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Glycosphingolipids (Sugar-Sphingosine Conjugates)
1969Publisher Summary Glycosphingolipids are a group of sphingolipids containing mono or oligosaccharide residues. The sugar residues are in direct or indirect glycosidic conjugation with the primary hydroxyl group of the N -acylated sphingosine or dihydrosphingosine molecule.
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Glycosynthase-Mediated Synthesis of Glycosphingolipids
Journal of the American Chemical Society, 2006Glycosphingolipids play crucial roles in virtually every stage of the cell cycle, and their clinical administration has been proposed as a treatment for Alzheimer's, Parkinson's, stroke, and a range of other conditions. However, lack of supply has severely hindered testing of this potential.
Mark D, Vaughan +5 more
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Ganglioside/glycosphingolipid turnover: New concepts
Glycoconjugate Journal, 2003In this review focus is given to the metabolic turnover of gangliosides/glycosphingolipids. The metabolism and accompanying intracellular trafficking of gangliosides/glycosphingolipids is illustrated with particular attention to the following events: (a) the de novo biosynthesis in the endoplasmic reticulum and Golgi apparatus, followed by vesicular ...
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